Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046537183> ?p ?o ?g. }
- W3046537183 endingPage "1335" @default.
- W3046537183 startingPage "1316" @default.
- W3046537183 abstract "Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that causes the progressive loss of motoneurons and, unfortunately, there is no effective treatment for this disease. Interconnecting multiple pathological mechanisms are involved in the neuropathology of this disease, including abnormal aggregation of proteins, neuroinflammation and dysregulation of the ubiquitin proteasome system. Such complex mechanisms, together with the lack of reliable animal models of the disease have hampered the development of drugs for this disease. Protein kinases, a key pharmacological target in several diseases, have been linked to ALS as they play a central role in the pathology of many diseases. Therefore several inhibitors are being currently trailed for clinical proof of concept in ALS patients. In this review, we examine the recent literature on protein kinase inhibitors currently in pharmaceutical development for this diseaseas future therapy for AS together with their involvement in the pathobiology of ALS. LINKED ARTICLES This article is part of a themed issue on Recent advances in ALS pathogenesis and therapeutics. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.6/issuetoc" @default.
- W3046537183 created "2020-08-07" @default.
- W3046537183 creator A5021512226 @default.
- W3046537183 creator A5027816150 @default.
- W3046537183 creator A5028669057 @default.
- W3046537183 creator A5060896107 @default.
- W3046537183 creator A5081701250 @default.
- W3046537183 date "2020-08-31" @default.
- W3046537183 modified "2023-10-14" @default.
- W3046537183 title "Protein kinase inhibitors for amyotrophic lateral sclerosis therapy" @default.
- W3046537183 cites W1014512415 @default.
- W3046537183 cites W1498274359 @default.
- W3046537183 cites W1522284801 @default.
- W3046537183 cites W1593989848 @default.
- W3046537183 cites W1656810399 @default.
- W3046537183 cites W1812777905 @default.
- W3046537183 cites W183820607 @default.
- W3046537183 cites W1886963552 @default.
- W3046537183 cites W1964780858 @default.
- W3046537183 cites W1966285532 @default.
- W3046537183 cites W1967313316 @default.
- W3046537183 cites W1968109664 @default.
- W3046537183 cites W1969093307 @default.
- W3046537183 cites W1969856246 @default.
- W3046537183 cites W1971725646 @default.
- W3046537183 cites W1977092589 @default.
- W3046537183 cites W1981720984 @default.
- W3046537183 cites W1982853502 @default.
- W3046537183 cites W1983128043 @default.
- W3046537183 cites W1983206452 @default.
- W3046537183 cites W1984133190 @default.
- W3046537183 cites W1985403672 @default.
- W3046537183 cites W1987264999 @default.
- W3046537183 cites W1993354361 @default.
- W3046537183 cites W1996815931 @default.
- W3046537183 cites W1998778692 @default.
- W3046537183 cites W2000614504 @default.
- W3046537183 cites W2001570690 @default.
- W3046537183 cites W2003618511 @default.
- W3046537183 cites W2005087727 @default.
- W3046537183 cites W2009108898 @default.
- W3046537183 cites W2013284164 @default.
- W3046537183 cites W2015836376 @default.
- W3046537183 cites W2018245189 @default.
- W3046537183 cites W2022792702 @default.
- W3046537183 cites W2024324841 @default.
- W3046537183 cites W2027420858 @default.
- W3046537183 cites W2029898167 @default.
- W3046537183 cites W2034275126 @default.
- W3046537183 cites W2036673560 @default.
- W3046537183 cites W2040249617 @default.
- W3046537183 cites W2041013746 @default.
- W3046537183 cites W2041451000 @default.
- W3046537183 cites W2042433752 @default.
- W3046537183 cites W2043710418 @default.
- W3046537183 cites W2044423100 @default.
- W3046537183 cites W2045077507 @default.
- W3046537183 cites W2047386018 @default.
- W3046537183 cites W2048323857 @default.
- W3046537183 cites W2049570656 @default.
- W3046537183 cites W2049628649 @default.
- W3046537183 cites W2056028176 @default.
- W3046537183 cites W2056778738 @default.
- W3046537183 cites W2059141941 @default.
- W3046537183 cites W2062408585 @default.
- W3046537183 cites W2064739805 @default.
- W3046537183 cites W2065455574 @default.
- W3046537183 cites W2067652401 @default.
- W3046537183 cites W2070348492 @default.
- W3046537183 cites W2071217673 @default.
- W3046537183 cites W2081457844 @default.
- W3046537183 cites W2081589139 @default.
- W3046537183 cites W2089353165 @default.
- W3046537183 cites W2089428725 @default.
- W3046537183 cites W2100143869 @default.
- W3046537183 cites W2100472603 @default.
- W3046537183 cites W2102238895 @default.
- W3046537183 cites W2106986615 @default.
- W3046537183 cites W2109679459 @default.
- W3046537183 cites W2111425566 @default.
- W3046537183 cites W2114108194 @default.
- W3046537183 cites W2123332775 @default.
- W3046537183 cites W2134408741 @default.
- W3046537183 cites W2138084122 @default.
- W3046537183 cites W2142460456 @default.
- W3046537183 cites W2149848093 @default.
- W3046537183 cites W2154055114 @default.
- W3046537183 cites W2164104132 @default.
- W3046537183 cites W2171943005 @default.
- W3046537183 cites W2204172854 @default.
- W3046537183 cites W2214185050 @default.
- W3046537183 cites W2233428981 @default.
- W3046537183 cites W2277515189 @default.
- W3046537183 cites W2312282875 @default.
- W3046537183 cites W2322746665 @default.
- W3046537183 cites W2343149131 @default.
- W3046537183 cites W2407003641 @default.
- W3046537183 cites W2473397587 @default.