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• W3046558097 abstract "Abstract This review addresses relevant aspects of Chagas disease in the solid organ transplantation setting. This trypanosomiasis was geographically restricted to America, but migration has turned Chagas disease into a global public health concern. Parasite persistence in chronically infected individuals entails the potential of transmission with organ donation and the potential for reactivation under immunosuppression. Prospective monitoring with real‐time PCR or direct methods for detection of parasitemia and treatment of documented episodes of transmission/ reactivation (rather than prophylactic treatment) is the recommended approach for managing patients at risk. Chagas disease is an important cause of terminal cardiomyopathy. Clinical results demonstrate that with adequate monitoring and treatment, patients with Chagas cardiomyopathy benefit from heart transplantation, with long‐term results even better than patients who underwent heart transplantation due to other conditions. Kidney and liver (and possibly other solid organs) transplantation can be safely performed in chronically infected patients with adequate management. Chronically infected patients are also suitable for organ donation (with the exception of the heart and intestines). Although reactivations and transmissions are observed, serious clinical disease is rare, and they are usually successfully managed with benznidazole or nifurtimox." @default.
• W3046558097 created "2020-08-07" @default.
• W3046558097 creator A5045477230 @default.
• W3046558097 creator A5066581034 @default.
• W3046558097 date "2020-08-16" @default.
• W3046558097 modified "2023-10-18" @default.
• W3046558097 title "American trypanosomiasis (Chagas disease) in solid organ transplantation" @default.
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• W3046558097 doi "https://doi.org/10.1111/tid.13429" @default.
• W3046558097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32738158" @default.
• W3046558097 hasPublicationYear "2020" @default.
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