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- W3046569692 abstract "Abstract The geometry of reaction compartments can affect the local outcome of interface‐restricted reactions. Giant unilamellar vesicles (GUVs) are commonly used to generate cell‐sized, membrane‐bound reaction compartments, which are, however, always spherical. Herein, we report the development of a microfluidic chip to trap and reversibly deform GUVs into cigar‐like shapes. When trapping and elongating GUVs that contain the primary protein of the bacterial Z ring, FtsZ, we find that membrane‐bound FtsZ filaments align preferentially with the short GUV axis. When GUVs are released from this confinement and membrane tension is relaxed, FtsZ reorganizes reversibly from filaments into dynamic rings that stabilize membrane protrusions; a process that allows reversible GUV deformation. We conclude that microfluidic traps are useful for manipulating both geometry and tension of GUVs, and for investigating how both affect the outcome of spatially‐sensitive reactions inside them, such as that of protein self‐organization." @default.
- W3046569692 created "2020-08-07" @default.
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- W3046569692 date "2020-09-17" @default.
- W3046569692 modified "2023-10-15" @default.
- W3046569692 title "FtsZ Reorganization Facilitates Deformation of Giant Vesicles in Microfluidic Traps**" @default.
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- W3046569692 doi "https://doi.org/10.1002/anie.202001928" @default.
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