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- W3046650483 abstract "Trafficking of cell-associated HIV-1 from the genital mucosa to lymphoid organs represents a critical first step toward systemic infection. Mature DCs capture and transmit HIV-1 to T cells, but insights into DC-to-T cell viral spread dynamics within a 3-dimensional environment is lacking. Using live-cell imaging, we show that mature DCs rapidly compartmentalize HIV-1 within surface-accessible invaginations near the uropod. HIV-1 capture did not interfere with DC migration toward lymph node homing chemo-attractants and their ability to enter lymphatic vessels. However, HIV-captured DCs engaged in prolonged contacts with autologous CD4+ T cells, which led to high T cell infection. Interestingly, we show that surface bound, virion-associated Env induced signal transduction in motile T cells that facilitated prolonged DC:T cell interactions, partially through high-affinity LFA-1 expression. Together, we describe a mechanism by which surface bound HIV-1 particles function as signaling receptors that regulate T cell motility, cell-cell contact dynamics, and productive infection." @default.
- W3046650483 created "2020-08-07" @default.
- W3046650483 creator A5013852175 @default.
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- W3046650483 creator A5072200033 @default.
- W3046650483 creator A5080358282 @default.
- W3046650483 date "2020-08-01" @default.
- W3046650483 modified "2023-10-16" @default.
- W3046650483 title "HIV-Captured DCs Regulate T Cell Migration and Cell-Cell Contact Dynamics to Enhance Viral Spread" @default.
- W3046650483 cites W1489762401 @default.
- W3046650483 cites W1516578436 @default.
- W3046650483 cites W1585425254 @default.
- W3046650483 cites W1607699671 @default.
- W3046650483 cites W1619221212 @default.
- W3046650483 cites W1641869325 @default.
- W3046650483 cites W1679721892 @default.
- W3046650483 cites W1892515422 @default.
- W3046650483 cites W1922318083 @default.
- W3046650483 cites W1946520978 @default.
- W3046650483 cites W1950109239 @default.
- W3046650483 cites W1967994686 @default.
- W3046650483 cites W1968135973 @default.
- W3046650483 cites W1969119554 @default.
- W3046650483 cites W1971907885 @default.
- W3046650483 cites W1974494916 @default.
- W3046650483 cites W1981160943 @default.
- W3046650483 cites W1988379927 @default.
- W3046650483 cites W1996939435 @default.
- W3046650483 cites W2003629451 @default.
- W3046650483 cites W2003902848 @default.
- W3046650483 cites W2006123588 @default.
- W3046650483 cites W2015776459 @default.
- W3046650483 cites W2016772494 @default.
- W3046650483 cites W2018475883 @default.
- W3046650483 cites W2019206924 @default.
- W3046650483 cites W2021224695 @default.
- W3046650483 cites W2024545340 @default.
- W3046650483 cites W2025346994 @default.
- W3046650483 cites W2025481552 @default.
- W3046650483 cites W2026487158 @default.
- W3046650483 cites W2034028541 @default.
- W3046650483 cites W2035871823 @default.
- W3046650483 cites W2037380046 @default.
- W3046650483 cites W2041774032 @default.
- W3046650483 cites W2043152270 @default.
- W3046650483 cites W2046888382 @default.
- W3046650483 cites W2051960468 @default.
- W3046650483 cites W2052612395 @default.
- W3046650483 cites W2056949914 @default.
- W3046650483 cites W2058740164 @default.
- W3046650483 cites W2062478481 @default.
- W3046650483 cites W2064593553 @default.
- W3046650483 cites W2065265587 @default.
- W3046650483 cites W2069554621 @default.
- W3046650483 cites W2069818169 @default.
- W3046650483 cites W2073933067 @default.
- W3046650483 cites W2075847325 @default.
- W3046650483 cites W2076225670 @default.
- W3046650483 cites W2077057101 @default.
- W3046650483 cites W2077798597 @default.
- W3046650483 cites W2078489697 @default.
- W3046650483 cites W2083889661 @default.
- W3046650483 cites W2084030449 @default.
- W3046650483 cites W2084965383 @default.
- W3046650483 cites W2085678099 @default.
- W3046650483 cites W2088493593 @default.
- W3046650483 cites W2089692155 @default.
- W3046650483 cites W2092787543 @default.
- W3046650483 cites W2095383876 @default.
- W3046650483 cites W2096269010 @default.
- W3046650483 cites W2096374450 @default.
- W3046650483 cites W2097004057 @default.
- W3046650483 cites W2098579054 @default.
- W3046650483 cites W2101515920 @default.
- W3046650483 cites W2101835696 @default.
- W3046650483 cites W2109590624 @default.
- W3046650483 cites W2112032194 @default.
- W3046650483 cites W2112112221 @default.
- W3046650483 cites W2113530391 @default.
- W3046650483 cites W2116364705 @default.
- W3046650483 cites W2123475341 @default.
- W3046650483 cites W2125453887 @default.
- W3046650483 cites W2128069859 @default.
- W3046650483 cites W2131317050 @default.
- W3046650483 cites W2134206256 @default.
- W3046650483 cites W2135163046 @default.
- W3046650483 cites W2138231208 @default.
- W3046650483 cites W2138652626 @default.
- W3046650483 cites W2138853264 @default.
- W3046650483 cites W2142173155 @default.
- W3046650483 cites W2143666216 @default.
- W3046650483 cites W2147880249 @default.
- W3046650483 cites W2149317992 @default.
- W3046650483 cites W2149412729 @default.