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- W3046665718 endingPage "19981" @default.
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- W3046665718 abstract "Significance The balance of mitochondrial fission and fusion, two aspects of mitochondrial dynamics, is important for mitochondrial function. In this study, we show that Caenorhabditis elegans lysosomal activity regulates mitochondrial dynamics by affecting mitochondrial fission through interfering the metabolism of a micronutrient, vitamin B12. Vitamin B12 is exclusively obtained from diets in animals, including C. elegans and humans, and its uptake is mediated by the lysosome. We show that lysosomal dysfunction causes vitamin B12 deficiency that leads to reduction of methionine and S-adenosylmethionine to in turn increase mitochondrial biogenesis and fission. Our study provides insight on the interactions between mitochondrial function and micronutrient metabolism." @default.
- W3046665718 created "2020-08-07" @default.
- W3046665718 creator A5062609711 @default.
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- W3046665718 date "2020-07-31" @default.
- W3046665718 modified "2023-10-16" @default.
- W3046665718 title "Lysosomal activity regulates <i>Caenorhabditis elegans</i> mitochondrial dynamics through vitamin B12 metabolism" @default.
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- W3046665718 doi "https://doi.org/10.1073/pnas.2008021117" @default.
- W3046665718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7443905" @default.
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- W3046665718 hasPublicationYear "2020" @default.
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