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- W3046671550 endingPage "19.2020" @default.
- W3046671550 startingPage "ENEURO.0012" @default.
- W3046671550 abstract "Abstract OTX2 is a homeoprotein transcription factor expressed in photoreceptors and bipolar cells in the retina. OTX2, like many other homeoproteins, transfers between cells and exerts non-cell autonomous effects such as promoting the survival of retinal ganglion cells that do not express the protein. Here we used a genetic approach to target extracellular OTX2 in the retina by conditional expression of a secreted single-chain anti-OTX2 antibody. Compared with control mice, the expression of this antibody by parvalbumin-expressing neurons in the retina is followed by a reduction in visual acuity in 1-month-old mice with no alteration of the retinal structure or cell type number or aspect. The a-waves and b-waves measured by electroretinogram were also indistinguishable from those of control mice, suggesting no functional deficit of photoreceptors and bipolar cells. Mice expressing the OTX2-neutralizing antibody did show a significant doubling in the flicker amplitude and a reduction in oscillatory potential, consistent with a change in inner retinal function. Our results show that interfering in vivo with OTX2 non-cell autonomous activity in the postnatal retina leads to an alteration in inner retinal cell functions and causes a deficit in visual acuity." @default.
- W3046671550 created "2020-08-07" @default.
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- W3046671550 date "2020-07-31" @default.
- W3046671550 modified "2023-10-15" @default.
- W3046671550 title "OTX2 Non-Cell Autonomous Activity Regulates Inner Retinal Function" @default.
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- W3046671550 doi "https://doi.org/10.1523/eneuro.0012-19.2020" @default.
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