FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046750173> ?p ?o ?g. }

• W3046750173 endingPage "113209" @default.
• W3046750173 startingPage "113209" @default.
• W3046750173 abstract "In traditional medicine, Glycyrrhiza glabra, commonly known as liquorice, is known to possess promising pharmacological properties including anti-oxidative, anti-inflammatory, gastro, hepato and nephro-protective activities. The present study investigated the protective effects of Glycyrrhiza glabra rhizome extract (GGE) on MTX-induced hepato-renal damage in Wistar albino rats. Rats were pre-treated with GGE (100, 200 or 400 mg/kg) from day 1 to 15 and administered MTX (20 mg/kg) on day 4. Methotrexate-induced hepato-renal damage was assessed by serum toxicity biomarkers (AST, ALT, BUN and creatinine), oxidative stress estimation (MDA, GSH, SOD, CAT, peroxidase and glutathione reductase), interleukins profiling (TNF-α, IL-1β, IL-6 and IL-12), tissue histopathology and immunohistochemical (caspase-3 and NFkB) examination. MTX induced hepato-renal damage resulted in elevated serum levels of AST, ALT, BUN and creatinine, increased pro-inflammatory cytokines concentration and accumulation of MDA and reduced levels of GSH, SOD, CAT, peroxidase and glutathione reductase. Conversely, co-treatment with GGE dose-dependently ameliorated oxidative stress, serum interleukins, hepato-renal toxicity biomarkers (p < 0.001), preserved tissue architecture and downregulated both caspase-3 and NFkB expression in hepato-renal tissue. The above results suggested that GGE can alleviate MTX-induced hepato-renal damage by decreasing oxidative stress and suppressing the ensuing activation of pro-apoptotic and pro-inflammatory pathways." @default.
• W3046750173 created "2020-08-07" @default.
• W3046750173 creator A5026438946 @default.
• W3046750173 creator A5027447226 @default.
• W3046750173 creator A5034421600 @default.
• W3046750173 creator A5058351630 @default.
• W3046750173 creator A5060211163 @default.
• W3046750173 creator A5088966509 @default.
• W3046750173 date "2020-12-01" @default.
• W3046750173 modified "2023-10-01" @default.
• W3046750173 title "Protective effects of Glycyrrhiza glabra supplementation against methotrexate-induced hepato-renal damage in rats: An experimental approach" @default.
• W3046750173 cites W1485133278 @default.
• W3046750173 cites W1521663232 @default.
• W3046750173 cites W1522182824 @default.
• W3046750173 cites W1553108076 @default.
• W3046750173 cites W1590457525 @default.
• W3046750173 cites W1883932206 @default.
• W3046750173 cites W191793640 @default.
• W3046750173 cites W1959511032 @default.
• W3046750173 cites W1981886300 @default.
• W3046750173 cites W1996669090 @default.
• W3046750173 cites W2014980326 @default.
• W3046750173 cites W2016969993 @default.
• W3046750173 cites W2022478533 @default.
• W3046750173 cites W2022631941 @default.
• W3046750173 cites W2029252545 @default.
• W3046750173 cites W2031643961 @default.
• W3046750173 cites W2038470789 @default.
• W3046750173 cites W2044004638 @default.
• W3046750173 cites W2055660855 @default.
• W3046750173 cites W2059973183 @default.
• W3046750173 cites W2086647019 @default.
• W3046750173 cites W2088866343 @default.
• W3046750173 cites W2124060758 @default.
• W3046750173 cites W2135919238 @default.
• W3046750173 cites W2145050940 @default.
• W3046750173 cites W2168024298 @default.
• W3046750173 cites W2197332903 @default.
• W3046750173 cites W2208379232 @default.
• W3046750173 cites W2289957912 @default.
• W3046750173 cites W2325707043 @default.
• W3046750173 cites W2424528953 @default.
• W3046750173 cites W2430932149 @default.
• W3046750173 cites W2606021524 @default.
• W3046750173 cites W2606816294 @default.
• W3046750173 cites W2734568804 @default.
• W3046750173 cites W2800869131 @default.
• W3046750173 cites W4293247451 @default.
• W3046750173 doi "https://doi.org/10.1016/j.jep.2020.113209" @default.
• W3046750173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32738390" @default.
• W3046750173 hasPublicationYear "2020" @default.
• W3046750173 type Work @default.
• W3046750173 sameAs 3046750173 @default.
• W3046750173 citedByCount "15" @default.
• W3046750173 countsByYear W30467501732021 @default.
• W3046750173 countsByYear W30467501732022 @default.
• W3046750173 countsByYear W30467501732023 @default.
• W3046750173 crossrefType "journal-article" @default.
• W3046750173 hasAuthorship W3046750173A5026438946 @default.
• W3046750173 hasAuthorship W3046750173A5027447226 @default.
• W3046750173 hasAuthorship W3046750173A5034421600 @default.
• W3046750173 hasAuthorship W3046750173A5058351630 @default.
• W3046750173 hasAuthorship W3046750173A5060211163 @default.
• W3046750173 hasAuthorship W3046750173A5088966509 @default.
• W3046750173 hasConcept C126322002 @default.
• W3046750173 hasConcept C165069038 @default.
• W3046750173 hasConcept C181199279 @default.
• W3046750173 hasConcept C185592680 @default.
• W3046750173 hasConcept C2775838275 @default.
• W3046750173 hasConcept C2776151105 @default.
• W3046750173 hasConcept C2778760513 @default.
• W3046750173 hasConcept C2780091579 @default.
• W3046750173 hasConcept C2780306776 @default.
• W3046750173 hasConcept C29730261 @default.
• W3046750173 hasConcept C538909803 @default.
• W3046750173 hasConcept C55493867 @default.
• W3046750173 hasConcept C71924100 @default.
• W3046750173 hasConcept C98274493 @default.
• W3046750173 hasConceptScore W3046750173C126322002 @default.
• W3046750173 hasConceptScore W3046750173C165069038 @default.
• W3046750173 hasConceptScore W3046750173C181199279 @default.
• W3046750173 hasConceptScore W3046750173C185592680 @default.
• W3046750173 hasConceptScore W3046750173C2775838275 @default.
• W3046750173 hasConceptScore W3046750173C2776151105 @default.
• W3046750173 hasConceptScore W3046750173C2778760513 @default.
• W3046750173 hasConceptScore W3046750173C2780091579 @default.
• W3046750173 hasConceptScore W3046750173C2780306776 @default.
• W3046750173 hasConceptScore W3046750173C29730261 @default.
• W3046750173 hasConceptScore W3046750173C538909803 @default.
• W3046750173 hasConceptScore W3046750173C55493867 @default.
• W3046750173 hasConceptScore W3046750173C71924100 @default.
• W3046750173 hasConceptScore W3046750173C98274493 @default.
• W3046750173 hasLocation W30467501731 @default.
• W3046750173 hasOpenAccess W3046750173 @default.
• W3046750173 hasPrimaryLocation W30467501731 @default.
• W3046750173 hasRelatedWork W1994127376 @default.
• W3046750173 hasRelatedWork W2026085986 @default.
• W3046750173 hasRelatedWork W2037965198 @default.

• next