FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046769061> ?p ?o ?g. }

• W3046769061 endingPage "11686" @default.
• W3046769061 startingPage "11681" @default.
• W3046769061 abstract "Tissue pH is tightly regulated in vivo, being a sensitive physiological biomarker. Advent of dissolution dynamic nuclear polarization (DNP) and its translation to humans stimulated development of pH-sensitive agents. However, requirements of DNP probes such as biocompatibility, signal sensitivity, and spin–lattice relaxation time (T1) complicate in vivo translation of the agents. Here, we developed a 13C-labeled alanine derivative, [1-13C]-l-alanine ethyl ester, as a viable DNP probe whose chemical shift is sensitive to the physiological pH range, and demonstrated the feasibility in phantoms and rat livers in vivo. Alanine ethyl ester readily crosses cell membrane while simultaneously assessing extracellular and intracellular pH in vivo. Following cell transport, [1-13C]-l-alanine ethyl ester is instantaneously hydrolyzed to [1-13C]-l-alanine, and subsequently metabolized to [1-13C]lactate and [13C]bicarbonate. The pH-insensitive alanine resonance was used as a reference." @default.
• W3046769061 created "2020-08-07" @default.
• W3046769061 creator A5000702864 @default.
• W3046769061 creator A5004588152 @default.
• W3046769061 creator A5026115452 @default.
• W3046769061 creator A5063902875 @default.
• W3046769061 creator A5068151898 @default.
• W3046769061 date "2020-07-30" @default.
• W3046769061 modified "2023-10-04" @default.
• W3046769061 title "Simultaneous Assessment of Intracellular and Extracellular pH Using Hyperpolarized [1-¹³C]Alanine Ethyl Ester" @default.
• W3046769061 cites W1485831589 @default.
• W3046769061 cites W150063240 @default.
• W3046769061 cites W1561899360 @default.
• W3046769061 cites W1735351005 @default.
• W3046769061 cites W1913712503 @default.
• W3046769061 cites W1963446564 @default.
• W3046769061 cites W1975107578 @default.
• W3046769061 cites W1981721404 @default.
• W3046769061 cites W1982784692 @default.
• W3046769061 cites W1983217073 @default.
• W3046769061 cites W1985089491 @default.
• W3046769061 cites W1986720548 @default.
• W3046769061 cites W1988007578 @default.
• W3046769061 cites W1991087280 @default.
• W3046769061 cites W2013404857 @default.
• W3046769061 cites W2032968749 @default.
• W3046769061 cites W2033385652 @default.
• W3046769061 cites W2059900570 @default.
• W3046769061 cites W2060681945 @default.
• W3046769061 cites W2066349475 @default.
• W3046769061 cites W2068847269 @default.
• W3046769061 cites W2078999243 @default.
• W3046769061 cites W2089936534 @default.
• W3046769061 cites W2093970530 @default.
• W3046769061 cites W2123251003 @default.
• W3046769061 cites W2146924006 @default.
• W3046769061 cites W2149902856 @default.
• W3046769061 cites W2163594803 @default.
• W3046769061 cites W2167795547 @default.
• W3046769061 cites W2171090291 @default.
• W3046769061 cites W2196729683 @default.
• W3046769061 cites W2280157727 @default.
• W3046769061 cites W2593235852 @default.
• W3046769061 cites W2613726711 @default.
• W3046769061 cites W2731549615 @default.
• W3046769061 cites W2758797028 @default.
• W3046769061 cites W2790731391 @default.
• W3046769061 cites W2791171542 @default.
• W3046769061 cites W2964104202 @default.
• W3046769061 cites W2985100448 @default.
• W3046769061 doi "https://doi.org/10.1021/acs.analchem.0c01568" @default.
• W3046769061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7522639" @default.
• W3046769061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32786486" @default.
• W3046769061 hasPublicationYear "2020" @default.
• W3046769061 type Work @default.
• W3046769061 sameAs 3046769061 @default.
• W3046769061 citedByCount "9" @default.
• W3046769061 countsByYear W30467690612020 @default.
• W3046769061 countsByYear W30467690612021 @default.
• W3046769061 countsByYear W30467690612022 @default.
• W3046769061 countsByYear W30467690612023 @default.
• W3046769061 crossrefType "journal-article" @default.
• W3046769061 hasAuthorship W3046769061A5000702864 @default.
• W3046769061 hasAuthorship W3046769061A5004588152 @default.
• W3046769061 hasAuthorship W3046769061A5026115452 @default.
• W3046769061 hasAuthorship W3046769061A5063902875 @default.
• W3046769061 hasAuthorship W3046769061A5068151898 @default.
• W3046769061 hasBestOaLocation W30467690612 @default.
• W3046769061 hasConcept C134897140 @default.
• W3046769061 hasConcept C150903083 @default.
• W3046769061 hasConcept C185592680 @default.
• W3046769061 hasConcept C207001950 @default.
• W3046769061 hasConcept C2779856020 @default.
• W3046769061 hasConcept C28406088 @default.
• W3046769061 hasConcept C515207424 @default.
• W3046769061 hasConcept C55493867 @default.
• W3046769061 hasConcept C79879829 @default.
• W3046769061 hasConcept C86803240 @default.
• W3046769061 hasConceptScore W3046769061C134897140 @default.
• W3046769061 hasConceptScore W3046769061C150903083 @default.
• W3046769061 hasConceptScore W3046769061C185592680 @default.
• W3046769061 hasConceptScore W3046769061C207001950 @default.
• W3046769061 hasConceptScore W3046769061C2779856020 @default.
• W3046769061 hasConceptScore W3046769061C28406088 @default.
• W3046769061 hasConceptScore W3046769061C515207424 @default.
• W3046769061 hasConceptScore W3046769061C55493867 @default.
• W3046769061 hasConceptScore W3046769061C79879829 @default.
• W3046769061 hasConceptScore W3046769061C86803240 @default.
• W3046769061 hasFunder F4320306196 @default.
• W3046769061 hasFunder F4320312093 @default.
• W3046769061 hasFunder F4320327708 @default.
• W3046769061 hasFunder F4320337363 @default.
• W3046769061 hasIssue "17" @default.
• W3046769061 hasLocation W30467690611 @default.
• W3046769061 hasLocation W30467690612 @default.
• W3046769061 hasOpenAccess W3046769061 @default.
• W3046769061 hasPrimaryLocation W30467690611 @default.
• W3046769061 hasRelatedWork W1756511575 @default.

• next