FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046770173> ?p ?o ?g. }

• W3046770173 abstract "Abstract Background Lyme disease is the most prevalent vector-borne disease in the USA with cases continuing to increase. Current control measures have not been shown to be impactful, and therefore alternatives are needed. Treating pathogen reservoirs with low dose systemic acaricides in endemic areas may provide a useful tool for disrupting the cycle of the vector and pathogen. The purpose of this study was to determine the efficacy of a 0.005% fipronil bait, presented orally to white-footed mice, in controlling blacklegged tick larvae (larvae). Methods Sixty mice were assigned to 3 treatment groups and three untreated control groups. All individually housed mice in treatment groups were exposed to 0.005% fipronil bait for 48 hours. Larvae were manually applied to mice within feeding capsules at one of three timepoints: Day 1, Day 9 and Day 15 post-exposure. For 4-days post-tick attachment, replete larvae were collected from water moats underneath each cage and attached larvae were observed by microscopy. Plasma from 4 treated mice at Day-1, Day 13 and Day 19, and 4 control mice ( n = 16) was collected to obtain fipronil plasma concentrations (CP). Results Fipronil bait did not appear to produce neophobia in mice, as the amount of bait eaten at 24- and 48-hours exposure did not differ significantly. The 48-hour fipronil bait exposure prevented 100% of larvae from feeding to repletion at Day 1, Day 9 and Day 15 post-treatment. Within the treatment groups, all larvae observable within the capsules expired and were prevented from detaching by Day 4. In contrast, within the control groups a total of 502 replete larvae were collected from moats and 348 larvae observable within the capsules successfully detached. CP averaged 948.9, 101.2 and 79.4 ng/ml for mice euthanized at Day 1, Day 9 and Day 15, respectively. No fipronil was detected in control mice. Conclusions We provide early indication that low dose fipronil bait, orally presented to white-footed mice, can effectively control blacklegged tick larvae. Future research should modify the exposure duration and post-exposure tick attachment timepoints to simulate various field scenarios under which successful efficacy might be obtained. Low dose fipronil bait could provide a cost-effective, practical means of controlling blacklegged ticks and other arthropod vectors." @default.
• W3046770173 created "2020-08-07" @default.
• W3046770173 creator A5002130741 @default.
• W3046770173 creator A5002554609 @default.
• W3046770173 creator A5027846982 @default.
• W3046770173 creator A5060949685 @default.
• W3046770173 creator A5061738446 @default.
• W3046770173 creator A5091354777 @default.
• W3046770173 date "2020-07-31" @default.
• W3046770173 modified "2023-10-16" @default.
• W3046770173 title "Efficacy of a low dose fipronil bait against blacklegged tick (Ixodes scapularis) larvae feeding on white-footed mice (Peromyscus leucopus) under laboratory conditions" @default.
• W3046770173 cites W1544976575 @default.
• W3046770173 cites W1985504839 @default.
• W3046770173 cites W1987114525 @default.
• W3046770173 cites W2017634740 @default.
• W3046770173 cites W2024511158 @default.
• W3046770173 cites W2043661728 @default.
• W3046770173 cites W2048797250 @default.
• W3046770173 cites W2087231443 @default.
• W3046770173 cites W2087920189 @default.
• W3046770173 cites W2093912953 @default.
• W3046770173 cites W2097787743 @default.
• W3046770173 cites W2126864975 @default.
• W3046770173 cites W2134612626 @default.
• W3046770173 cites W2147409965 @default.
• W3046770173 cites W2158738482 @default.
• W3046770173 cites W2173208118 @default.
• W3046770173 cites W2173317328 @default.
• W3046770173 cites W2176188147 @default.
• W3046770173 cites W2178044845 @default.
• W3046770173 cites W2189222687 @default.
• W3046770173 cites W2313282319 @default.
• W3046770173 cites W2316686245 @default.
• W3046770173 cites W2319190519 @default.
• W3046770173 cites W2321800624 @default.
• W3046770173 cites W2328235698 @default.
• W3046770173 cites W2333050621 @default.
• W3046770173 cites W2614669740 @default.
• W3046770173 cites W2728494892 @default.
• W3046770173 cites W2807555032 @default.
• W3046770173 cites W2883197795 @default.
• W3046770173 cites W2892190253 @default.
• W3046770173 cites W3005592839 @default.
• W3046770173 cites W4249306618 @default.
• W3046770173 cites W4386277460 @default.
• W3046770173 cites W4386277816 @default.
• W3046770173 cites W3143444769 @default.
• W3046770173 doi "https://doi.org/10.1186/s13071-020-04258-0" @default.
• W3046770173 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8424918" @default.
• W3046770173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34493330" @default.
• W3046770173 hasPublicationYear "2020" @default.
• W3046770173 type Work @default.
• W3046770173 sameAs 3046770173 @default.
• W3046770173 citedByCount "11" @default.
• W3046770173 countsByYear W30467701732020 @default.
• W3046770173 countsByYear W30467701732021 @default.
• W3046770173 countsByYear W30467701732022 @default.
• W3046770173 countsByYear W30467701732023 @default.
• W3046770173 crossrefType "journal-article" @default.
• W3046770173 hasAuthorship W3046770173A5002130741 @default.
• W3046770173 hasAuthorship W3046770173A5002554609 @default.
• W3046770173 hasAuthorship W3046770173A5027846982 @default.
• W3046770173 hasAuthorship W3046770173A5060949685 @default.
• W3046770173 hasAuthorship W3046770173A5061738446 @default.
• W3046770173 hasAuthorship W3046770173A5091354777 @default.
• W3046770173 hasBestOaLocation W30467701731 @default.
• W3046770173 hasConcept C140793950 @default.
• W3046770173 hasConcept C161176658 @default.
• W3046770173 hasConcept C173758957 @default.
• W3046770173 hasConcept C18903297 @default.
• W3046770173 hasConcept C2776127032 @default.
• W3046770173 hasConcept C2776397665 @default.
• W3046770173 hasConcept C2777095047 @default.
• W3046770173 hasConcept C2779620486 @default.
• W3046770173 hasConcept C2781401430 @default.
• W3046770173 hasConcept C2781453105 @default.
• W3046770173 hasConcept C33070731 @default.
• W3046770173 hasConcept C42972112 @default.
• W3046770173 hasConcept C71924100 @default.
• W3046770173 hasConcept C74714110 @default.
• W3046770173 hasConcept C86803240 @default.
• W3046770173 hasConcept C90856448 @default.
• W3046770173 hasConceptScore W3046770173C140793950 @default.
• W3046770173 hasConceptScore W3046770173C161176658 @default.
• W3046770173 hasConceptScore W3046770173C173758957 @default.
• W3046770173 hasConceptScore W3046770173C18903297 @default.
• W3046770173 hasConceptScore W3046770173C2776127032 @default.
• W3046770173 hasConceptScore W3046770173C2776397665 @default.
• W3046770173 hasConceptScore W3046770173C2777095047 @default.
• W3046770173 hasConceptScore W3046770173C2779620486 @default.
• W3046770173 hasConceptScore W3046770173C2781401430 @default.
• W3046770173 hasConceptScore W3046770173C2781453105 @default.
• W3046770173 hasConceptScore W3046770173C33070731 @default.
• W3046770173 hasConceptScore W3046770173C42972112 @default.
• W3046770173 hasConceptScore W3046770173C71924100 @default.
• W3046770173 hasConceptScore W3046770173C74714110 @default.
• W3046770173 hasConceptScore W3046770173C86803240 @default.
• W3046770173 hasConceptScore W3046770173C90856448 @default.
• W3046770173 hasIssue "1" @default.
• W3046770173 hasLocation W30467701731 @default.

• next