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- W3046819344 abstract "903 A tetravalent chimeric anti-human CD22 antibody (cRFB4-TetraMAb) with improved anti-tumor activity has been developed. The DNA encoding the single chain Fv (scFv) was spliced to the Fc of human IgG1 and expressed in Chinese hamster ovary cells. The construct was purified on Sepharose- Protein G followed by HPLC. The characteristics of the cTetraMAb were analyzed and compared to its parental divalent MAb, RFB4. The TetraMAb bound to CD22+ Daudi cells as well as the divalent RFB4, but had a slower dissociation rate. Both the TetraMAb and the divalent RFB4 bound equally well to FcγR-positive human cells, to human C1q, and to recombinant human FcRn in vitro. It also had comparable ADCC activity when human effector cells were used. Despite its slightly larger size, the TetraMAb penetrated normal tissues in Swiss Webster mice as well as the divalent MAb. The TetraMAb had a longer half-life in both Swiss Webster mice and mFcRn-/hFcRn+ transgenic mice, and it showed improved anti-tumor activity in SCID mice xenografted with various CD22 positive human tumor cell lines. Moreover, the enhanced activity of the TetraMAb was dose-related. In conclusion, these data suggest that this tetravalent RFB4 antibody should be further developed for human use." @default.
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- W3046819344 date "2007-05-01" @default.
- W3046819344 modified "2023-10-03" @default.
- W3046819344 title "Characterization and anti-tumor activity of a chimeric tetravalent anti-CD22 monoclonal antibody" @default.
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