Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046827891> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3046827891 endingPage "6" @default.
- W3046827891 startingPage "1" @default.
- W3046827891 abstract "Objective: To evaluate all the known factors that may play a role in predicting response to Neoadjuvant chemotherapy in breast cancer and to see impact of response on five years’ disease free survival (DFS) and Overallsurvival (OS). Material and Method: Data of 156 patients was reviewed retrospectively from January 2012 to December 2012 at Shaukat Khanum Memorial Cancer Hospital and Research Centre Lahore, Pakistan. All received neoadjuvant chemotherapy (NAC) and had no distant metastasis. The response was measured in term of percentage reduction from 1st radiological size on presentation to final size on histopathology (of resected specimen). Four groups were identified, complete responder (CR) (100% reduction), Responders (R) (>50% reduction), Partial responder (PR) (<50% reduction) and Non-responder (NR). Relationship of predictive factors with each response group was observed. Five year survival was noted for each response group. Result: Median age of patients was 45 years (25-64 years). 67% of patients underwent breast conservation surgery, while the rest underwent mastectomy. Mortality for whole group was 22%, and recurrence was shown in 34% (Majority i.e. 26% were distant, while contralateral were 3%). Out of 156 patients, 25% of patients were CR, 13% were NR, 23% were PR and 37% were R. Progesterone receptor negative and Grade III tumors showed more complete responses. The Rest of the receptor types, including triple negative, initial T and N stage and other clinical factors showed no impact on chemo-response. Survival was significantly poor in NR group (45% OS, 40% DFS), while rest of three groups had comparable survival outcome, with CR group having best survival outcome (86% OS, 80% DFS). Conclusion: Most of factors studied did not show impact on achieving good chemo response, however good chemo response did show better survival." @default.
- W3046827891 created "2020-08-07" @default.
- W3046827891 creator A5014193519 @default.
- W3046827891 creator A5015783595 @default.
- W3046827891 creator A5019888930 @default.
- W3046827891 creator A5025074505 @default.
- W3046827891 creator A5040166900 @default.
- W3046827891 creator A5061130965 @default.
- W3046827891 creator A5063770559 @default.
- W3046827891 creator A5071173706 @default.
- W3046827891 creator A5089581742 @default.
- W3046827891 creator A5089676521 @default.
- W3046827891 date "2020-08-03" @default.
- W3046827891 modified "2023-10-17" @default.
- W3046827891 title "Predictive Factors Involved in Determining Response to Neoadjuvant Chemotherapy in Breast Cancer and Impact of Response on 5 Years Disease Free Survival and Overall Survival" @default.
- W3046827891 doi "https://doi.org/10.31487/j.cor.2020.08.05" @default.
- W3046827891 hasPublicationYear "2020" @default.
- W3046827891 type Work @default.
- W3046827891 sameAs 3046827891 @default.
- W3046827891 citedByCount "0" @default.
- W3046827891 crossrefType "journal-article" @default.
- W3046827891 hasAuthorship W3046827891A5014193519 @default.
- W3046827891 hasAuthorship W3046827891A5015783595 @default.
- W3046827891 hasAuthorship W3046827891A5019888930 @default.
- W3046827891 hasAuthorship W3046827891A5025074505 @default.
- W3046827891 hasAuthorship W3046827891A5040166900 @default.
- W3046827891 hasAuthorship W3046827891A5061130965 @default.
- W3046827891 hasAuthorship W3046827891A5063770559 @default.
- W3046827891 hasAuthorship W3046827891A5071173706 @default.
- W3046827891 hasAuthorship W3046827891A5089581742 @default.
- W3046827891 hasAuthorship W3046827891A5089676521 @default.
- W3046827891 hasBestOaLocation W30468278911 @default.
- W3046827891 hasConcept C121608353 @default.
- W3046827891 hasConcept C126322002 @default.
- W3046827891 hasConcept C141071460 @default.
- W3046827891 hasConcept C143998085 @default.
- W3046827891 hasConcept C146357865 @default.
- W3046827891 hasConcept C151730666 @default.
- W3046827891 hasConcept C2776694085 @default.
- W3046827891 hasConcept C2777757722 @default.
- W3046827891 hasConcept C2778292576 @default.
- W3046827891 hasConcept C2780110267 @default.
- W3046827891 hasConcept C3019096185 @default.
- W3046827891 hasConcept C530470458 @default.
- W3046827891 hasConcept C71924100 @default.
- W3046827891 hasConcept C86803240 @default.
- W3046827891 hasConcept C90924648 @default.
- W3046827891 hasConceptScore W3046827891C121608353 @default.
- W3046827891 hasConceptScore W3046827891C126322002 @default.
- W3046827891 hasConceptScore W3046827891C141071460 @default.
- W3046827891 hasConceptScore W3046827891C143998085 @default.
- W3046827891 hasConceptScore W3046827891C146357865 @default.
- W3046827891 hasConceptScore W3046827891C151730666 @default.
- W3046827891 hasConceptScore W3046827891C2776694085 @default.
- W3046827891 hasConceptScore W3046827891C2777757722 @default.
- W3046827891 hasConceptScore W3046827891C2778292576 @default.
- W3046827891 hasConceptScore W3046827891C2780110267 @default.
- W3046827891 hasConceptScore W3046827891C3019096185 @default.
- W3046827891 hasConceptScore W3046827891C530470458 @default.
- W3046827891 hasConceptScore W3046827891C71924100 @default.
- W3046827891 hasConceptScore W3046827891C86803240 @default.
- W3046827891 hasConceptScore W3046827891C90924648 @default.
- W3046827891 hasLocation W30468278911 @default.
- W3046827891 hasOpenAccess W3046827891 @default.
- W3046827891 hasPrimaryLocation W30468278911 @default.
- W3046827891 hasRelatedWork W1970677298 @default.
- W3046827891 hasRelatedWork W2161568138 @default.
- W3046827891 hasRelatedWork W2365134123 @default.
- W3046827891 hasRelatedWork W2367105124 @default.
- W3046827891 hasRelatedWork W2367335376 @default.
- W3046827891 hasRelatedWork W2588049562 @default.
- W3046827891 hasRelatedWork W3160106878 @default.
- W3046827891 hasRelatedWork W4238701032 @default.
- W3046827891 hasRelatedWork W4288428757 @default.
- W3046827891 hasRelatedWork W3128871921 @default.
- W3046827891 isParatext "false" @default.
- W3046827891 isRetracted "false" @default.
- W3046827891 magId "3046827891" @default.
- W3046827891 workType "article" @default.