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• W3046830265 abstract "Neurofibrillary tangle (NFT) imaging methods at the distinct scales of atomic and whole-brain resolutions have coevolved rapidly. Linking these two areas of research provides insight into how and why certain tau radiotracers, using positron emission tomography (PET), bind selectively to certain morphological forms of the NFT fibril. In this Review, a brief history and background for each research area is presented leading to a summary of the current state of knowledge, with a synopsis of PET NFT radiotracers and an outlook for near-term research efforts. The continued integration of information provided at the level of each of these scales of resolution will catalyze the next generation of clinical imaging technique development and enhance our interpretations of them." @default.
• W3046830265 created "2020-08-07" @default.
• W3046830265 creator A5004605097 @default.
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• W3046830265 creator A5028353553 @default.
• W3046830265 date "2020-07-30" @default.
• W3046830265 modified "2023-09-28" @default.
• W3046830265 title "Coevolution of Atomic Resolution and Whole-Brain Imaging for Tau Neurofibrillary Tangles" @default.
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• W3046830265 doi "https://doi.org/10.1021/acschemneuro.0c00426" @default.
• W3046830265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32786315" @default.

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