Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046883508> ?p ?o ?g. }
- W3046883508 endingPage "115288" @default.
- W3046883508 startingPage "115288" @default.
- W3046883508 abstract "Monobutyl phthalate (MBP) is a primary metabolite of an environmental endocrine disruptor dibutyl phthalate (DBP), which poses a potential threat to living organisms. In this research, the acute toxicity of MBP on energy metabolism in zebrafish gills was studied. Transmission electron microscopy (TEM) results show that 10 mg L-1 MBP can induce mitochondrial structural damage of chloride cells after 96 h of continuous exposure. The activity of ion ATPase and the expression level of oxidative phosphorylation-related genes suggest that MBP interferes with ATP synthesis and ion transport. Further leading to a decrease in mitochondrial membrane potential (MMP) and cell viability, thereby mediating early-stage cell apoptosis. Through a comprehensive analysis of principal component analysis (PCA) and integrated biomarker response (IBR) scores, atp5a1, a subunit of mitochondrial ATP synthase, is mainly inhibited by MBP, followed by genes encoding ion ATPase (atp1b2 and atp2b1). Importantly, MBP inhibits aerobic metabolism by inhibiting the key enzyme malate dehydrogenase (MDH) in the TCA cycle, forcing zebrafish to maintain ATP supply by enhancing anaerobic metabolism." @default.
- W3046883508 created "2020-08-07" @default.
- W3046883508 creator A5014110805 @default.
- W3046883508 creator A5017806003 @default.
- W3046883508 creator A5025620768 @default.
- W3046883508 creator A5030502007 @default.
- W3046883508 creator A5042973046 @default.
- W3046883508 creator A5049692788 @default.
- W3046883508 creator A5063487915 @default.
- W3046883508 creator A5064132086 @default.
- W3046883508 creator A5073216396 @default.
- W3046883508 creator A5089439923 @default.
- W3046883508 date "2020-11-01" @default.
- W3046883508 modified "2023-09-29" @default.
- W3046883508 title "Monobutyl phthalate (MBP) induces energy metabolism disturbances in the gills of adult zebrafish (Danio rerio)" @default.
- W3046883508 cites W1782577945 @default.
- W3046883508 cites W1965784476 @default.
- W3046883508 cites W1995102486 @default.
- W3046883508 cites W2015192043 @default.
- W3046883508 cites W2016277947 @default.
- W3046883508 cites W2025184034 @default.
- W3046883508 cites W2026205682 @default.
- W3046883508 cites W2035989388 @default.
- W3046883508 cites W2038848727 @default.
- W3046883508 cites W2061092938 @default.
- W3046883508 cites W2079497895 @default.
- W3046883508 cites W2084920249 @default.
- W3046883508 cites W2092548955 @default.
- W3046883508 cites W2104744942 @default.
- W3046883508 cites W2129797562 @default.
- W3046883508 cites W2150837319 @default.
- W3046883508 cites W2218127057 @default.
- W3046883508 cites W2464073148 @default.
- W3046883508 cites W2466954014 @default.
- W3046883508 cites W2511133664 @default.
- W3046883508 cites W2615903563 @default.
- W3046883508 cites W2783896051 @default.
- W3046883508 cites W2786133187 @default.
- W3046883508 cites W2790930241 @default.
- W3046883508 cites W2802414822 @default.
- W3046883508 cites W2804644743 @default.
- W3046883508 cites W2808711807 @default.
- W3046883508 cites W2884916558 @default.
- W3046883508 cites W2891136035 @default.
- W3046883508 cites W2901551469 @default.
- W3046883508 cites W2914224589 @default.
- W3046883508 cites W2923077634 @default.
- W3046883508 cites W2940447044 @default.
- W3046883508 cites W2945092764 @default.
- W3046883508 cites W2950188939 @default.
- W3046883508 cites W2955132418 @default.
- W3046883508 cites W2956531740 @default.
- W3046883508 cites W2980099030 @default.
- W3046883508 cites W2980275734 @default.
- W3046883508 cites W2987185450 @default.
- W3046883508 cites W2999797668 @default.
- W3046883508 cites W908658222 @default.
- W3046883508 doi "https://doi.org/10.1016/j.envpol.2020.115288" @default.
- W3046883508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32795888" @default.
- W3046883508 hasPublicationYear "2020" @default.
- W3046883508 type Work @default.
- W3046883508 sameAs 3046883508 @default.
- W3046883508 citedByCount "10" @default.
- W3046883508 countsByYear W30468835082021 @default.
- W3046883508 countsByYear W30468835082022 @default.
- W3046883508 countsByYear W30468835082023 @default.
- W3046883508 crossrefType "journal-article" @default.
- W3046883508 hasAuthorship W3046883508A5014110805 @default.
- W3046883508 hasAuthorship W3046883508A5017806003 @default.
- W3046883508 hasAuthorship W3046883508A5025620768 @default.
- W3046883508 hasAuthorship W3046883508A5030502007 @default.
- W3046883508 hasAuthorship W3046883508A5042973046 @default.
- W3046883508 hasAuthorship W3046883508A5049692788 @default.
- W3046883508 hasAuthorship W3046883508A5063487915 @default.
- W3046883508 hasAuthorship W3046883508A5064132086 @default.
- W3046883508 hasAuthorship W3046883508A5073216396 @default.
- W3046883508 hasAuthorship W3046883508A5089439923 @default.
- W3046883508 hasConcept C104317684 @default.
- W3046883508 hasConcept C132901563 @default.
- W3046883508 hasConcept C161153951 @default.
- W3046883508 hasConcept C165135838 @default.
- W3046883508 hasConcept C181199279 @default.
- W3046883508 hasConcept C185592680 @default.
- W3046883508 hasConcept C23265538 @default.
- W3046883508 hasConcept C2776878037 @default.
- W3046883508 hasConcept C2780384893 @default.
- W3046883508 hasConcept C28859421 @default.
- W3046883508 hasConcept C2909208804 @default.
- W3046883508 hasConcept C505870484 @default.
- W3046883508 hasConcept C55493867 @default.
- W3046883508 hasConcept C57600042 @default.
- W3046883508 hasConcept C62231903 @default.
- W3046883508 hasConcept C86803240 @default.
- W3046883508 hasConcept C95444343 @default.
- W3046883508 hasConceptScore W3046883508C104317684 @default.
- W3046883508 hasConceptScore W3046883508C132901563 @default.
- W3046883508 hasConceptScore W3046883508C161153951 @default.
- W3046883508 hasConceptScore W3046883508C165135838 @default.