FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3046930892> ?p ?o ?g. }

• W3046930892 endingPage "5095" @default.
• W3046930892 startingPage "5078" @default.
• W3046930892 abstract "Background and Purpose Staphylococcal enterotoxin‐B (SEB) is one of the most potent bacterial superantigens that exerts profound toxic effects by inducing a cytokine storm. Inhaled SEB can cause acute respiratory distress syndrome (ARDS), which is often fatal and with no effective treatments. Experimental Approach Efficacy of Δ 9 ‐tetrahydrocannabinol (THC) was tested in a mouse model of SEB‐mediated ARDS, in which lung inflammation, alterations in gut/lung microbiota and production of short‐chain fatty acids (SCFAs) was measured. Gene dysregulation of lung epithelial cells was studied by transcriptome arrays. Faecal microbiota transplantation (FMT) was performed to confirm the role of microbiota in suppressing ARDS. Key Results While SEB triggered ARDS and 100% mortality in mice, THC protected the mice from fatality. Pyrosequencing analysis revealed that THC caused significant and similar alterations in microbiota in the lungs and gut of mice exposed to SEB. THC significantly increased the abundance of beneficial bacterial species, Ruminococcus gnavus , but decreased pathogenic microbiota, Akkermansia muciniphila. FMT confirmed that THC‐mediated reversal of microbial dysbiosis played crucial role in attenuation of SEB‐mediated ARDS. THC treatment caused an increase in SCFA, of which propionic acid was found to inhibit the inflammatory response. Transcriptome array showed that THC up‐regulated several genes like lysozyme1 and lysozyme2, β‐defensin‐2, claudin, zonula‐1, occludin‐1, Mucin2 and Muc5b while down‐regulating β‐defensin‐1. Conclusion and Implications The study demonstrates for the first time that THC attenuates SEB‐mediated ARDS and toxicity by altering the microbiota in the lungs and the gut as well as promoting antimicrobial and anti‐inflammatory pathways." @default.
• W3046930892 created "2020-08-10" @default.
• W3046930892 creator A5013247022 @default.
• W3046930892 creator A5018707155 @default.
• W3046930892 creator A5023882456 @default.
• W3046930892 creator A5033984994 @default.
• W3046930892 creator A5061239650 @default.
• W3046930892 creator A5091773676 @default.
• W3046930892 date "2020-10-08" @default.
• W3046930892 modified "2023-10-15" @default.
• W3046930892 title "Protective effects of Δ⁹‐tetrahydrocannabinol against enterotoxin‐induced acute respiratory distress syndrome are mediated by modulation of microbiota" @default.
• W3046930892 cites W1776971359 @default.
• W3046930892 cites W1929782941 @default.
• W3046930892 cites W1969711244 @default.
• W3046930892 cites W1974477809 @default.
• W3046930892 cites W1974880556 @default.
• W3046930892 cites W1980544777 @default.
• W3046930892 cites W1985020940 @default.
• W3046930892 cites W1994778879 @default.
• W3046930892 cites W2004299225 @default.
• W3046930892 cites W2008440267 @default.
• W3046930892 cites W2008780228 @default.
• W3046930892 cites W2008906556 @default.
• W3046930892 cites W2012011074 @default.
• W3046930892 cites W2019419945 @default.
• W3046930892 cites W2022392385 @default.
• W3046930892 cites W2030619237 @default.
• W3046930892 cites W2038100201 @default.
• W3046930892 cites W2065033340 @default.
• W3046930892 cites W2076044688 @default.
• W3046930892 cites W2085991415 @default.
• W3046930892 cites W2103552948 @default.
• W3046930892 cites W2116475552 @default.
• W3046930892 cites W2119279345 @default.
• W3046930892 cites W2120876285 @default.
• W3046930892 cites W2121777852 @default.
• W3046930892 cites W2130505168 @default.
• W3046930892 cites W2133856765 @default.
• W3046930892 cites W2142127071 @default.
• W3046930892 cites W2162859509 @default.
• W3046930892 cites W2168065686 @default.
• W3046930892 cites W2170017798 @default.
• W3046930892 cites W2181471414 @default.
• W3046930892 cites W2193881805 @default.
• W3046930892 cites W2260904257 @default.
• W3046930892 cites W2262897529 @default.
• W3046930892 cites W2267861477 @default.
• W3046930892 cites W2274927794 @default.
• W3046930892 cites W2278586243 @default.
• W3046930892 cites W2315387408 @default.
• W3046930892 cites W2409656339 @default.
• W3046930892 cites W2586448379 @default.
• W3046930892 cites W2595451311 @default.
• W3046930892 cites W2760290205 @default.
• W3046930892 cites W2765851819 @default.
• W3046930892 cites W2766413288 @default.
• W3046930892 cites W2768366016 @default.
• W3046930892 cites W2769489268 @default.
• W3046930892 cites W2776567026 @default.
• W3046930892 cites W2789447956 @default.
• W3046930892 cites W2790180970 @default.
• W3046930892 cites W2791419854 @default.
• W3046930892 cites W2879618324 @default.
• W3046930892 cites W2887841170 @default.
• W3046930892 cites W2894539749 @default.
• W3046930892 cites W2905681354 @default.
• W3046930892 cites W2924958031 @default.
• W3046930892 cites W2928535033 @default.
• W3046930892 cites W2951185044 @default.
• W3046930892 cites W2952093130 @default.
• W3046930892 cites W2963332926 @default.
• W3046930892 cites W2964768231 @default.
• W3046930892 cites W2965488855 @default.
• W3046930892 cites W2971942945 @default.
• W3046930892 cites W2975416296 @default.
• W3046930892 cites W2982132719 @default.
• W3046930892 cites W3013643089 @default.
• W3046930892 cites W3042519295 @default.
• W3046930892 cites W4211250103 @default.
• W3046930892 cites W4236357753 @default.
• W3046930892 cites W4297085868 @default.
• W3046930892 doi "https://doi.org/10.1111/bph.15226" @default.
• W3046930892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7436585" @default.
• W3046930892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32754917" @default.
• W3046930892 hasPublicationYear "2020" @default.
• W3046930892 type Work @default.
• W3046930892 sameAs 3046930892 @default.
• W3046930892 citedByCount "26" @default.
• W3046930892 countsByYear W30469308922020 @default.
• W3046930892 countsByYear W30469308922021 @default.
• W3046930892 countsByYear W30469308922022 @default.
• W3046930892 countsByYear W30469308922023 @default.
• W3046930892 crossrefType "journal-article" @default.
• W3046930892 hasAuthorship W3046930892A5013247022 @default.
• W3046930892 hasAuthorship W3046930892A5018707155 @default.
• W3046930892 hasAuthorship W3046930892A5023882456 @default.
• W3046930892 hasAuthorship W3046930892A5033984994 @default.
• W3046930892 hasAuthorship W3046930892A5061239650 @default.

• next