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- W3046966497 abstract "The iron complex of 2-[bis(pyridin-2-ylmethyl)amino]-N-(quinolin-8-yl)acetylamide (H-dpaq) has been proven to cleave DNA by reductive oxygen activation. Two H-dpaq derivatives, H-dpaq-Arg8-NH2 and H-dpaq-spermine, having a cationic tail as a DNA binding unit, octa-arginine or spermine, have been synthesized and evaluated in the iron-catalyzed oxidative DNA cleavage of plasmid DNA, pUC19, in the presence of a reducing agent. H-dpaq-Arg8-NH2 and H-dpaq-spermine converted the supercoiled form of pUC19 to the nicked form 2.7- and 3.5-fold more efficiently than H-dpaq. A pentadentate mono-carboxamide ligand having spermine as a DNA binding domain showed higher oxidative DNA cleavage activity in the presence of iron ion by reductive dioxygen activation than a counterpart having an octa-arginine tail, despite the smaller number of positive charges." @default.
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- W3046966497 date "2020-11-05" @default.
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- W3046966497 title "Enhanced Oxidative DNA Cleavage Activity of Iron Complex of Pentadentate Mono-carboxamide Ligand Having Spermine as DNA Binding Domain" @default.
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- W3046966497 doi "https://doi.org/10.1246/cl.200493" @default.
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