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• W3047018993 abstract "The accumulation of tumor-specific CD4+ and CD8+ effector T cells is key to an effective antitumor response. Locally, CD4+ T cells promote the recruitment and effector function of tumor-specific CD8+ T cells and activate innate killer cells in the tumor. Here, we show that tumor-specific CD4+ T cells were predominantly present in the CD39+ subset of tumor-infiltrating lymphocytes (TIL). The CD39+ CD4+ and CD8+ TILs were detected in three different tumor types, and displayed an activated (PD-1+, HLA-DR+) effector memory phenotype. CD4+CD39+ single-cell RNA-sequenced TILs shared similar well-known activation, tissue residency, and effector cell-associated genes with CD8+CD39+CD103+ TILs. Finally, analysis of directly ex vivo cell-sorted and in vitro expanded pure populations of CD39-positive and negative CD4+ and CD8+ TILs revealed that tumor-specific antigen reactivity was almost exclusively detected among CD39+ cells. Immunotherapy of cancer is based on the activation of tumor-reactive CD4+ and CD8+ T cells. We show that the expression of CD39 can be used to identify, isolate, and expand tumor-reactive T-cell populations in cancers." @default.
• W3047018993 created "2020-08-10" @default.
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• W3047018993 date "2020-10-01" @default.
• W3047018993 modified "2023-10-14" @default.
• W3047018993 title "CD39 Identifies the CD4+ Tumor-Specific T-cell Population in Human Cancer" @default.
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• W3047018993 doi "https://doi.org/10.1158/2326-6066.cir-20-0270" @default.
• W3047018993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32759363" @default.
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