FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047023202> ?p ?o ?g. }

• W3047023202 endingPage "2743" @default.
• W3047023202 startingPage "2733" @default.
• W3047023202 abstract "Candida tropicalis (C. tropicalis) has emerged as an important fungal pathogen due to its increasing resistance to conventional antifungal agents, especially fluconazole (FLC). Pseudolaric acid B (PAB), a herbal-originated diterpene acid from Pseudolarix kaempferi Gordon, has been reported to possess inhibitory activity against fungus. The present study aims to investigate the antifungal effect of PAB alone and in combination with FLC on planktonic and biofilm cells of C. tropicalis.The antifungal activity of PAB against planktonic isolates was evaluated alone and in combination with FLC using the chequerboard microdilution method and growth curve assay. The anti-biofilm effects were quantified by tetrazolium (XTT) reduction assay, which were further confirmed by scanning electron microscopy (SEM) and fluorescent microscope to observe morphological changes of biofilm treated with PAB and FLC.It was revealed that PAB alone exhibited similar inhibitory activity against FLC-resistant and FLC-susceptible strains with median MIC ranging from 8 to 16 µg/mL. When administered in combination, synergism was observed in all (13/13) FLC-resistant and (2/9) FLC-susceptible strains with FICI ranging from 0.070 to 0.375. Moreover, the concomitant use of PAB and FLC exhibited a strong dose-dependent synergistic inhibitory effect on the early and mature biofilm, eliminating more than 80% biofilm formation. SEM found that PAB, different from azoles, could significantly inhibit spore germination and destroy the cell integrity causing cell deformation, swelling, collapse and outer membrane perforation.PAB was highly active against FLC-resistant isolates and biofilm of C. tropicalis, particularly when combined with FLC. These findings suggest that PAB may have potential as a novel antifungal agent with different targets from azole drugs." @default.
• W3047023202 created "2020-08-10" @default.
• W3047023202 creator A5000221151 @default.
• W3047023202 creator A5003689944 @default.
• W3047023202 creator A5010786305 @default.
• W3047023202 creator A5025325761 @default.
• W3047023202 creator A5030540787 @default.
• W3047023202 creator A5044988770 @default.
• W3047023202 creator A5046338494 @default.
• W3047023202 creator A5058552497 @default.
• W3047023202 creator A5082980713 @default.
• W3047023202 date "2020-08-01" @default.
• W3047023202 modified "2023-10-18" @default.
• W3047023202 title "<p>Synergistic Effect of Pseudolaric Acid B with Fluconazole Against Resistant Isolates and Biofilm of <em>Candida tropicalis</em></p>" @default.
• W3047023202 cites W1480514463 @default.
• W3047023202 cites W1854179725 @default.
• W3047023202 cites W1980106726 @default.
• W3047023202 cites W1985979029 @default.
• W3047023202 cites W2038211225 @default.
• W3047023202 cites W2092973008 @default.
• W3047023202 cites W2121194579 @default.
• W3047023202 cites W2170764510 @default.
• W3047023202 cites W2252911663 @default.
• W3047023202 cites W2334493659 @default.
• W3047023202 cites W2464884033 @default.
• W3047023202 cites W2523042273 @default.
• W3047023202 cites W2528151165 @default.
• W3047023202 cites W2533400345 @default.
• W3047023202 cites W2731792518 @default.
• W3047023202 cites W2738416721 @default.
• W3047023202 cites W2739660851 @default.
• W3047023202 cites W2750383476 @default.
• W3047023202 cites W2761420273 @default.
• W3047023202 cites W2770964395 @default.
• W3047023202 cites W2792847166 @default.
• W3047023202 cites W2798262844 @default.
• W3047023202 cites W2801270682 @default.
• W3047023202 cites W2807041387 @default.
• W3047023202 cites W2884740022 @default.
• W3047023202 cites W2903217741 @default.
• W3047023202 cites W2912291213 @default.
• W3047023202 cites W3014880574 @default.
• W3047023202 cites W3018869764 @default.
• W3047023202 doi "https://doi.org/10.2147/idr.s261299" @default.
• W3047023202 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7415455" @default.
• W3047023202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32801807" @default.
• W3047023202 hasPublicationYear "2020" @default.
• W3047023202 type Work @default.
• W3047023202 sameAs 3047023202 @default.
• W3047023202 citedByCount "7" @default.
• W3047023202 countsByYear W30470232022021 @default.
• W3047023202 countsByYear W30470232022022 @default.
• W3047023202 countsByYear W30470232022023 @default.
• W3047023202 crossrefType "journal-article" @default.
• W3047023202 hasAuthorship W3047023202A5000221151 @default.
• W3047023202 hasAuthorship W3047023202A5003689944 @default.
• W3047023202 hasAuthorship W3047023202A5010786305 @default.
• W3047023202 hasAuthorship W3047023202A5025325761 @default.
• W3047023202 hasAuthorship W3047023202A5030540787 @default.
• W3047023202 hasAuthorship W3047023202A5044988770 @default.
• W3047023202 hasAuthorship W3047023202A5046338494 @default.
• W3047023202 hasAuthorship W3047023202A5058552497 @default.
• W3047023202 hasAuthorship W3047023202A5082980713 @default.
• W3047023202 hasBestOaLocation W30470232021 @default.
• W3047023202 hasConcept C176947019 @default.
• W3047023202 hasConcept C185592680 @default.
• W3047023202 hasConcept C2775835631 @default.
• W3047023202 hasConcept C2779548794 @default.
• W3047023202 hasConcept C2780651595 @default.
• W3047023202 hasConcept C2780950330 @default.
• W3047023202 hasConcept C4937899 @default.
• W3047023202 hasConcept C523546767 @default.
• W3047023202 hasConcept C54355233 @default.
• W3047023202 hasConcept C58123911 @default.
• W3047023202 hasConcept C86803240 @default.
• W3047023202 hasConcept C89423630 @default.
• W3047023202 hasConceptScore W3047023202C176947019 @default.
• W3047023202 hasConceptScore W3047023202C185592680 @default.
• W3047023202 hasConceptScore W3047023202C2775835631 @default.
• W3047023202 hasConceptScore W3047023202C2779548794 @default.
• W3047023202 hasConceptScore W3047023202C2780651595 @default.
• W3047023202 hasConceptScore W3047023202C2780950330 @default.
• W3047023202 hasConceptScore W3047023202C4937899 @default.
• W3047023202 hasConceptScore W3047023202C523546767 @default.
• W3047023202 hasConceptScore W3047023202C54355233 @default.
• W3047023202 hasConceptScore W3047023202C58123911 @default.
• W3047023202 hasConceptScore W3047023202C86803240 @default.
• W3047023202 hasConceptScore W3047023202C89423630 @default.
• W3047023202 hasLocation W30470232021 @default.
• W3047023202 hasLocation W30470232022 @default.
• W3047023202 hasLocation W30470232023 @default.
• W3047023202 hasOpenAccess W3047023202 @default.
• W3047023202 hasPrimaryLocation W30470232021 @default.
• W3047023202 hasRelatedWork W1555208341 @default.
• W3047023202 hasRelatedWork W1969010760 @default.
• W3047023202 hasRelatedWork W2104015273 @default.
• W3047023202 hasRelatedWork W2371643008 @default.
• W3047023202 hasRelatedWork W2969172153 @default.

• next