Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047146415> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W3047146415 endingPage "104" @default.
- W3047146415 startingPage "97" @default.
- W3047146415 abstract "Proton pump inhibitors (PPIs) have wide pleiotropic action in addition to their therapeutic potential in gastroesophageal reflux diseases. Conversely, recent reports revealed a significant incidence of toxic events of PPIs including nephritis, osteoporosis, and cardiac damage. Thus, the study was designed to reconcile the deceptive contraindications. The present investigation targeted to reveal the toxic impact of sub-acute and sub-chronic administration of pantoprazole (PPZ) with different concentrations (low dose 4 mg/kg, medium-dose 8 mg/kg and high dose 16 mg/kg once a day) on normal vascular endothelium and renal tissue of rats. Vascular endothelial dysfunction (VED) was estimated by the contractility of an isolated aortic ring, nitrite/nitrate concentration, oxidative stress, and integrity of the endothelium layer. Moreover, the renal abnormalities were further confirmed by an increased level of serum creatinine, blood urea nitrogen (BUN), the incidence of microproteinuria, and structural alteration. Sub-acute administration of PPZ treatment did not produce any toxicological impact on endothelium and renal tissue. Whereas, sub-chronic administration of PPZ treatment causes moderate VED and renal dysfunction in a dose-dependent manner. Sub-chronic treatment of PPZ also influences the mitigation of NO and elevation of oxidative stress. Collecting all the evidence, it concludes that decreased nitric oxide availability and increased levels of oxidative stress may be a possible underlying mechanism of causing VED and renal abnormalities from high-dose PPZ treatment." @default.
- W3047146415 created "2020-08-10" @default.
- W3047146415 creator A5002455860 @default.
- W3047146415 creator A5069022273 @default.
- W3047146415 creator A5080445916 @default.
- W3047146415 date "2020-10-01" @default.
- W3047146415 modified "2023-09-25" @default.
- W3047146415 title "Dose and time-dependent toxicological impact of pantoprazole on vascular endothelium and renal tissue" @default.
- W3047146415 cites W1578396116 @default.
- W3047146415 cites W1912306896 @default.
- W3047146415 cites W1965048573 @default.
- W3047146415 cites W2041363234 @default.
- W3047146415 cites W2048548077 @default.
- W3047146415 cites W2078854975 @default.
- W3047146415 cites W2138386369 @default.
- W3047146415 cites W2196949431 @default.
- W3047146415 cites W2198148859 @default.
- W3047146415 cites W2290466312 @default.
- W3047146415 cites W2300272821 @default.
- W3047146415 cites W2337938280 @default.
- W3047146415 cites W2523522924 @default.
- W3047146415 cites W2590483831 @default.
- W3047146415 cites W2607062467 @default.
- W3047146415 cites W2616715279 @default.
- W3047146415 cites W2737132193 @default.
- W3047146415 cites W2769780742 @default.
- W3047146415 cites W2793728426 @default.
- W3047146415 cites W2799547484 @default.
- W3047146415 cites W2890425962 @default.
- W3047146415 cites W2927993870 @default.
- W3047146415 cites W2941740296 @default.
- W3047146415 cites W2980351639 @default.
- W3047146415 cites W3015926690 @default.
- W3047146415 cites W4247050267 @default.
- W3047146415 doi "https://doi.org/10.1016/j.toxlet.2020.07.031" @default.
- W3047146415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32763312" @default.
- W3047146415 hasPublicationYear "2020" @default.
- W3047146415 type Work @default.
- W3047146415 sameAs 3047146415 @default.
- W3047146415 citedByCount "3" @default.
- W3047146415 countsByYear W30471464152022 @default.
- W3047146415 countsByYear W30471464152023 @default.
- W3047146415 crossrefType "journal-article" @default.
- W3047146415 hasAuthorship W3047146415A5002455860 @default.
- W3047146415 hasAuthorship W3047146415A5069022273 @default.
- W3047146415 hasAuthorship W3047146415A5080445916 @default.
- W3047146415 hasConcept C126322002 @default.
- W3047146415 hasConcept C134018914 @default.
- W3047146415 hasConcept C159641895 @default.
- W3047146415 hasConcept C2776151105 @default.
- W3047146415 hasConcept C2776992346 @default.
- W3047146415 hasConcept C2780091579 @default.
- W3047146415 hasConcept C2780306776 @default.
- W3047146415 hasConcept C2780972559 @default.
- W3047146415 hasConcept C519581460 @default.
- W3047146415 hasConcept C71924100 @default.
- W3047146415 hasConcept C98274493 @default.
- W3047146415 hasConceptScore W3047146415C126322002 @default.
- W3047146415 hasConceptScore W3047146415C134018914 @default.
- W3047146415 hasConceptScore W3047146415C159641895 @default.
- W3047146415 hasConceptScore W3047146415C2776151105 @default.
- W3047146415 hasConceptScore W3047146415C2776992346 @default.
- W3047146415 hasConceptScore W3047146415C2780091579 @default.
- W3047146415 hasConceptScore W3047146415C2780306776 @default.
- W3047146415 hasConceptScore W3047146415C2780972559 @default.
- W3047146415 hasConceptScore W3047146415C519581460 @default.
- W3047146415 hasConceptScore W3047146415C71924100 @default.
- W3047146415 hasConceptScore W3047146415C98274493 @default.
- W3047146415 hasLocation W30471464151 @default.
- W3047146415 hasLocation W30471464152 @default.
- W3047146415 hasOpenAccess W3047146415 @default.
- W3047146415 hasPrimaryLocation W30471464151 @default.
- W3047146415 hasRelatedWork W1573451568 @default.
- W3047146415 hasRelatedWork W1973610105 @default.
- W3047146415 hasRelatedWork W2020959757 @default.
- W3047146415 hasRelatedWork W2042033030 @default.
- W3047146415 hasRelatedWork W2044943066 @default.
- W3047146415 hasRelatedWork W2070511355 @default.
- W3047146415 hasRelatedWork W2113143771 @default.
- W3047146415 hasRelatedWork W2127085070 @default.
- W3047146415 hasRelatedWork W2161227917 @default.
- W3047146415 hasRelatedWork W2400445066 @default.
- W3047146415 hasVolume "333" @default.
- W3047146415 isParatext "false" @default.
- W3047146415 isRetracted "false" @default.
- W3047146415 magId "3047146415" @default.
- W3047146415 workType "article" @default.