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- W3047156922 endingPage "5600" @default.
- W3047156922 startingPage "5600" @default.
- W3047156922 abstract "The maintenance of bone mass is a dynamic process that requires a strict balance between bone formation and resorption. Bone formation is controlled by osteoblasts, while osteoclasts are responsible for resorption of the bone matrix. The opposite functions of these cell types have to be tightly regulated not only during normal bone development, but also during adult life, to maintain serum calcium homeostasis and sustain bone integrity to prevent bone fractures. Disruption of the control of bone synthesis or resorption can lead to an over accumulation of bone tissue in osteopetrosis or conversely to a net depletion of the bone mass in osteoporosis. Moreover, high levels of bone resorption with focal bone formation can cause Paget’s disease. Here, we summarize the steps toward isolation and characterization of the osteopetrosis associated trans-membrane protein 1 (Ostm1) gene and protein, essential for proper osteoclast maturation, and responsible when mutated for the most severe form of osteopetrosis in mice and humans." @default.
- W3047156922 created "2020-08-10" @default.
- W3047156922 creator A5000486634 @default.
- W3047156922 creator A5026043721 @default.
- W3047156922 creator A5045332954 @default.
- W3047156922 date "2020-08-05" @default.
- W3047156922 modified "2023-10-13" @default.
- W3047156922 title "Ostm1 from Mouse to Human: Insights into Osteoclast Maturation" @default.
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