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- W3047158476 abstract "ABSTRACT Processive exoribonucleases, the executors of RNA decay, participate in multiple physical and functional interactions. Unlike physical ones, functional relationships have not been investigated in human cells. Here we have screened cells deficient in DIS3, XRN2, EXOSC10, DIS3L, and DIS3L2 with a custom siRNA library and determined their functional interactions with diverse pathways of RNA metabolism. We uncover a complex network of positive interactions that buffer alterations in RNA degradation. We reveal important reciprocal actions between RNA decay and transcription and explore alleviating interactions between RNA splicing and DIS3 mediated degradation. We also use a large scale library of genes associated with RNA metabolism to determine genetic interactions of nuclear DIS3 and cytoplasmic DIS3L, revealing their unique functions in RNA degradation and uncovering cooperation between the cytoplasmic degradation and nuclear processing of RNA. Finally, genome-wide siRNA screening of DIS3 reveals processes such as microtubule organization and regulation of telomerase activity that are also functionally associated with nuclear exosome-mediated RNA degradation." @default.
- W3047158476 created "2020-08-10" @default.
- W3047158476 creator A5015241213 @default.
- W3047158476 creator A5019033469 @default.
- W3047158476 creator A5051974214 @default.
- W3047158476 creator A5052175358 @default.
- W3047158476 creator A5075943909 @default.
- W3047158476 creator A5082888270 @default.
- W3047158476 creator A5086051241 @default.
- W3047158476 date "2020-08-06" @default.
- W3047158476 modified "2023-09-26" @default.
- W3047158476 title "High-throughput siRNA screening reveals functional interactions and redundancies of human processive exoribonucleases" @default.
- W3047158476 cites W1508168356 @default.
- W3047158476 cites W1515360736 @default.
- W3047158476 cites W1545725142 @default.
- W3047158476 cites W1801843862 @default.
- W3047158476 cites W1879741103 @default.
- W3047158476 cites W1910770669 @default.
- W3047158476 cites W1963899959 @default.
- W3047158476 cites W1974434328 @default.
- W3047158476 cites W1981074253 @default.
- W3047158476 cites W1982187148 @default.
- W3047158476 cites W1986911150 @default.
- W3047158476 cites W1987607182 @default.
- W3047158476 cites W1995224771 @default.
- W3047158476 cites W1995481648 @default.
- W3047158476 cites W1997535872 @default.
- W3047158476 cites W1999721918 @default.
- W3047158476 cites W2001569497 @default.
- W3047158476 cites W2003731662 @default.
- W3047158476 cites W2004731223 @default.
- W3047158476 cites W2009720434 @default.
- W3047158476 cites W2010461414 @default.
- W3047158476 cites W2014241716 @default.
- W3047158476 cites W2016625616 @default.
- W3047158476 cites W2022148218 @default.
- W3047158476 cites W2022294016 @default.
- W3047158476 cites W2025075195 @default.
- W3047158476 cites W2025859016 @default.
- W3047158476 cites W2028061670 @default.
- W3047158476 cites W2028475698 @default.
- W3047158476 cites W2030677655 @default.
- W3047158476 cites W2035300822 @default.
- W3047158476 cites W2035618305 @default.
- W3047158476 cites W2037622313 @default.
- W3047158476 cites W2038649062 @default.
- W3047158476 cites W2039233506 @default.
- W3047158476 cites W2041440237 @default.
- W3047158476 cites W2046754106 @default.
- W3047158476 cites W2046995371 @default.
- W3047158476 cites W2048557198 @default.
- W3047158476 cites W2055413437 @default.
- W3047158476 cites W2056586488 @default.
- W3047158476 cites W2067293798 @default.
- W3047158476 cites W2068205741 @default.
- W3047158476 cites W2070686658 @default.
- W3047158476 cites W2070829661 @default.
- W3047158476 cites W2092126428 @default.
- W3047158476 cites W2097203532 @default.
- W3047158476 cites W2098474935 @default.
- W3047158476 cites W2099814921 @default.
- W3047158476 cites W2101035019 @default.
- W3047158476 cites W2106052289 @default.
- W3047158476 cites W2111064166 @default.
- W3047158476 cites W2117022436 @default.
- W3047158476 cites W2120818838 @default.
- W3047158476 cites W2122746312 @default.
- W3047158476 cites W2123847993 @default.
- W3047158476 cites W2124088276 @default.
- W3047158476 cites W2127073167 @default.
- W3047158476 cites W2133176364 @default.
- W3047158476 cites W2133678935 @default.
- W3047158476 cites W2138505594 @default.
- W3047158476 cites W2143350291 @default.
- W3047158476 cites W2146558686 @default.
- W3047158476 cites W2151126975 @default.
- W3047158476 cites W2154076229 @default.
- W3047158476 cites W2154376431 @default.
- W3047158476 cites W2154819492 @default.
- W3047158476 cites W2156679982 @default.
- W3047158476 cites W2158217645 @default.
- W3047158476 cites W2158411073 @default.
- W3047158476 cites W2159675211 @default.
- W3047158476 cites W2160166757 @default.
- W3047158476 cites W2160697532 @default.
- W3047158476 cites W2161491874 @default.
- W3047158476 cites W2163636666 @default.
- W3047158476 cites W2164516436 @default.
- W3047158476 cites W2169896860 @default.
- W3047158476 cites W2175867816 @default.
- W3047158476 cites W2176357689 @default.
- W3047158476 cites W2176579203 @default.
- W3047158476 cites W2178007530 @default.
- W3047158476 cites W2182726182 @default.
- W3047158476 cites W2192959916 @default.
- W3047158476 cites W2202553770 @default.
- W3047158476 cites W2216658435 @default.
- W3047158476 cites W2229093700 @default.
- W3047158476 cites W2297344571 @default.
- W3047158476 cites W2300198160 @default.