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- W3047182371 endingPage "5578" @default.
- W3047182371 startingPage "5578" @default.
- W3047182371 abstract "Human cytomegalovirus (HCMV) is a major human pathogen associated with severe pathology. Current options of antiviral therapy only partly satisfy the needs of a well-tolerated long-term treatment/prophylaxis free from drug-induced viral resistance. Recently, we reported the strong antiviral properties in vitro and in vivo of the broad-spectrum anti-infective drug artesunate and its optimized derivatives. NF-κB signaling was described as a targeting mechanism and additional target proteins have recently been identified. Here, we analyzed the autofluorescent hybrid compound BG95, which could be utilized for intracellular visualization by confocal imaging and a tracking analysis in virus-infected primary human fibroblasts. As an important finding, BG95 accumulated in mitochondria visualized by anti-prohibitin and MitoTracker staining, and induced statistically significant changes of mitochondrial morphology, distinct from those induced by HCMV infection. Notably, mitochondrial membrane potential was found substantially reduced by BG95, an effect apparently counteracting efficient HCMV replication, which requires active mitochondria and upregulated energy levels. This finding was consistent with binding properties of artesunate-like compounds to mitochondrial proteins and thereby suggested a new mechanistic aspect. Combined, the present study underlines an important role of mitochondria in the multifaceted, host-directed antiviral mechanism of this drug class, postulating a new mitochondria-specific mode of protein targeting." @default.
- W3047182371 created "2020-08-10" @default.
- W3047182371 creator A5002128015 @default.
- W3047182371 creator A5004166511 @default.
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- W3047182371 creator A5036578632 @default.
- W3047182371 creator A5040808433 @default.
- W3047182371 creator A5046466492 @default.
- W3047182371 creator A5053550707 @default.
- W3047182371 creator A5075525711 @default.
- W3047182371 creator A5084250942 @default.
- W3047182371 creator A5090720967 @default.
- W3047182371 date "2020-08-04" @default.
- W3047182371 modified "2023-09-27" @default.
- W3047182371 title "The Artemisinin-Derived Autofluorescent Compound BG95 Exerts Strong Anticytomegaloviral Activity Based on a Mitochondrial Targeting Mechanism" @default.
- W3047182371 cites W1159651283 @default.
- W3047182371 cites W1902278985 @default.
- W3047182371 cites W1957027480 @default.
- W3047182371 cites W1963728755 @default.
- W3047182371 cites W1964066906 @default.
- W3047182371 cites W1966600968 @default.
- W3047182371 cites W1971020007 @default.
- W3047182371 cites W1971933057 @default.
- W3047182371 cites W1972280183 @default.
- W3047182371 cites W1981276113 @default.
- W3047182371 cites W1985302263 @default.
- W3047182371 cites W1985387611 @default.
- W3047182371 cites W1991297121 @default.
- W3047182371 cites W1992403094 @default.
- W3047182371 cites W2002002442 @default.
- W3047182371 cites W2005150915 @default.
- W3047182371 cites W2008230870 @default.
- W3047182371 cites W2009230567 @default.
- W3047182371 cites W2015823022 @default.
- W3047182371 cites W2016216633 @default.
- W3047182371 cites W2017916023 @default.
- W3047182371 cites W2018579991 @default.
- W3047182371 cites W2019763610 @default.
- W3047182371 cites W2020939886 @default.
- W3047182371 cites W2024964682 @default.
- W3047182371 cites W2026419574 @default.
- W3047182371 cites W2033778630 @default.
- W3047182371 cites W2039288286 @default.
- W3047182371 cites W2044936417 @default.
- W3047182371 cites W2046433603 @default.
- W3047182371 cites W2047276100 @default.
- W3047182371 cites W2051864533 @default.
- W3047182371 cites W2054776071 @default.
- W3047182371 cites W2059690571 @default.
- W3047182371 cites W2061593050 @default.
- W3047182371 cites W2061941938 @default.
- W3047182371 cites W2062051365 @default.
- W3047182371 cites W2071637493 @default.
- W3047182371 cites W2077185287 @default.
- W3047182371 cites W2098962649 @default.
- W3047182371 cites W2099788710 @default.
- W3047182371 cites W2108502979 @default.
- W3047182371 cites W2108928565 @default.
- W3047182371 cites W2109010226 @default.
- W3047182371 cites W2109369471 @default.
- W3047182371 cites W2114795453 @default.
- W3047182371 cites W2116490605 @default.
- W3047182371 cites W2118279792 @default.
- W3047182371 cites W2118497859 @default.
- W3047182371 cites W2123344591 @default.
- W3047182371 cites W2125622509 @default.
- W3047182371 cites W2126789240 @default.
- W3047182371 cites W2127729530 @default.
- W3047182371 cites W2130187195 @default.
- W3047182371 cites W2130220157 @default.
- W3047182371 cites W2137481369 @default.
- W3047182371 cites W2138360960 @default.
- W3047182371 cites W2141935262 @default.
- W3047182371 cites W2146424231 @default.
- W3047182371 cites W2148976224 @default.
- W3047182371 cites W2150432764 @default.
- W3047182371 cites W2151981672 @default.
- W3047182371 cites W2154938348 @default.
- W3047182371 cites W2158973497 @default.
- W3047182371 cites W2170863323 @default.
- W3047182371 cites W2171991500 @default.
- W3047182371 cites W2191485687 @default.
- W3047182371 cites W2197997311 @default.
- W3047182371 cites W2202885949 @default.
- W3047182371 cites W2234562695 @default.
- W3047182371 cites W2264363593 @default.
- W3047182371 cites W2267970607 @default.
- W3047182371 cites W2280182364 @default.
- W3047182371 cites W2319680233 @default.
- W3047182371 cites W2335536436 @default.
- W3047182371 cites W2400242674 @default.
- W3047182371 cites W2401728478 @default.
- W3047182371 cites W2538210965 @default.
- W3047182371 cites W2557659496 @default.
- W3047182371 cites W2562224769 @default.
- W3047182371 cites W2566427216 @default.
- W3047182371 cites W2588850090 @default.
- W3047182371 cites W2593104383 @default.