Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047186722> ?p ?o ?g. }
- W3047186722 abstract "Abstract Hepatoblastoma (HB) is the most common malignant liver tumor in children. Abnormal activation of the Wnt/β-catenin signaling pathway plays an important role in the formation and development of HB. Genes in HB show a global hypomethylation change, accompanied by hypermethylation of specific tumor suppressor genes (TSGs). This article reviews the hypermethylation changes in several TSGs, such as RASSF1A, SOCS1, APC, HHIP, and P16, and analyzes the pathways and mechanisms of TSGs regulating gene expression. The role of the methylation-regulating enzymes DNA methyltransferases (DNMTs) and ten-eleven translocation (TET) family members enzymes in the methylation changes of HB was analyzed, and it was speculated that the occurrence of HB is partly due to the obstruction of liver differentiation in the early stage of differentiation. The origin cells may be incompletely differentiated hepatocytes remaining in the liver of children after birth. Therefore, further studying the role of methylation regulating enzymes in methylation changes in HB is a promising future research direction." @default.
- W3047186722 created "2020-08-10" @default.
- W3047186722 creator A5030733600 @default.
- W3047186722 creator A5045268803 @default.
- W3047186722 creator A5048495389 @default.
- W3047186722 creator A5052110962 @default.
- W3047186722 creator A5080705993 @default.
- W3047186722 date "2020-08-05" @default.
- W3047186722 modified "2023-09-23" @default.
- W3047186722 title "DNA methylation in Hepatoblastoma-a literature review" @default.
- W3047186722 cites W1522860394 @default.
- W3047186722 cites W1563035833 @default.
- W3047186722 cites W1917164803 @default.
- W3047186722 cites W1962345472 @default.
- W3047186722 cites W1962814197 @default.
- W3047186722 cites W1964646880 @default.
- W3047186722 cites W1969986557 @default.
- W3047186722 cites W1971981581 @default.
- W3047186722 cites W1974747095 @default.
- W3047186722 cites W1974937624 @default.
- W3047186722 cites W1976489901 @default.
- W3047186722 cites W1981515025 @default.
- W3047186722 cites W1981894827 @default.
- W3047186722 cites W1989501772 @default.
- W3047186722 cites W1991638248 @default.
- W3047186722 cites W1992591047 @default.
- W3047186722 cites W1995160678 @default.
- W3047186722 cites W1996113298 @default.
- W3047186722 cites W2001568293 @default.
- W3047186722 cites W2005351392 @default.
- W3047186722 cites W2009648600 @default.
- W3047186722 cites W2030921003 @default.
- W3047186722 cites W2049220630 @default.
- W3047186722 cites W2055254495 @default.
- W3047186722 cites W2059105000 @default.
- W3047186722 cites W2060661794 @default.
- W3047186722 cites W2068127752 @default.
- W3047186722 cites W2070016388 @default.
- W3047186722 cites W2072923665 @default.
- W3047186722 cites W2079097689 @default.
- W3047186722 cites W2082827623 @default.
- W3047186722 cites W2085033610 @default.
- W3047186722 cites W2085361442 @default.
- W3047186722 cites W2086062087 @default.
- W3047186722 cites W2090685132 @default.
- W3047186722 cites W2098227124 @default.
- W3047186722 cites W2101092609 @default.
- W3047186722 cites W2108632501 @default.
- W3047186722 cites W2108720678 @default.
- W3047186722 cites W2113492051 @default.
- W3047186722 cites W2124079918 @default.
- W3047186722 cites W2141654290 @default.
- W3047186722 cites W2142948889 @default.
- W3047186722 cites W2146784968 @default.
- W3047186722 cites W2161483331 @default.
- W3047186722 cites W2163395475 @default.
- W3047186722 cites W2166965065 @default.
- W3047186722 cites W2168000404 @default.
- W3047186722 cites W2168473428 @default.
- W3047186722 cites W2185829260 @default.
- W3047186722 cites W2191176937 @default.
- W3047186722 cites W2271556415 @default.
- W3047186722 cites W2301794227 @default.
- W3047186722 cites W2325267338 @default.
- W3047186722 cites W2341664663 @default.
- W3047186722 cites W2414449891 @default.
- W3047186722 cites W2460054528 @default.
- W3047186722 cites W2558881870 @default.
- W3047186722 cites W2562696573 @default.
- W3047186722 cites W2563210415 @default.
- W3047186722 cites W2565650469 @default.
- W3047186722 cites W2737149496 @default.
- W3047186722 cites W2740523213 @default.
- W3047186722 cites W2752906129 @default.
- W3047186722 cites W2767823610 @default.
- W3047186722 cites W2769234034 @default.
- W3047186722 cites W2770491998 @default.
- W3047186722 cites W2792445669 @default.
- W3047186722 cites W2794608908 @default.
- W3047186722 cites W2800504341 @default.
- W3047186722 cites W2886418899 @default.
- W3047186722 cites W2896661470 @default.
- W3047186722 cites W2900958958 @default.
- W3047186722 cites W2904176130 @default.
- W3047186722 cites W2916357429 @default.
- W3047186722 cites W2949758427 @default.
- W3047186722 cites W2954673706 @default.
- W3047186722 cites W2960418263 @default.
- W3047186722 cites W635191475 @default.
- W3047186722 doi "https://doi.org/10.1186/s13052-020-00877-6" @default.
- W3047186722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7409486" @default.
- W3047186722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32758256" @default.
- W3047186722 hasPublicationYear "2020" @default.
- W3047186722 type Work @default.
- W3047186722 sameAs 3047186722 @default.
- W3047186722 citedByCount "7" @default.
- W3047186722 countsByYear W30471867222021 @default.
- W3047186722 countsByYear W30471867222022 @default.
- W3047186722 crossrefType "journal-article" @default.
- W3047186722 hasAuthorship W3047186722A5030733600 @default.