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• W3047193582 endingPage "1434" @default.
• W3047193582 startingPage "1425" @default.
• W3047193582 abstract "Periodontitis is a complex, multifactorial chronic disease involving continuous interactions among bacteria, host immune/inflammatory responses, and modifying genetic and environmental factors. More than any other cytokine family, the interleukin (IL)-1 family includes key signaling molecules that trigger and perpetuate periodontal inflammation. Over the years, the IL-1 family expanded to include 11 members of cytokines, some with agonist activity (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, and IL-36γ), receptor antagonists (IL-1Ra, IL-36Ra), and 2 anti-inflammatory cytokines (IL-37, IL-38). The IL-1 receptor antagonist (IL-1Ra) has emerged as a pivotal player in the defense against periodontitis. IL-33 primarily induces the production of Th2-associated cytokines but acts as an alarmin via stimulation of mast cells. The IL-36 subclass of cytokines may be important in regulating mucosal inflammation and homeostasis. IL-37 suppresses innate and acquired immune responses. IL-38 is the most recent member of the IL-1 superfamily and has anti-inflammatory properties similar to those of IL-37 but through different receptors. However, limited evidence exists regarding the role of IL-37 and IL-38 in periodontitis. Despite the development of IL-1 blocking agents, therapeutic blockade of select IL-1 family members for periodontitis has only been partially investigated in preclinical and clinical research, while the development of IL-37 and IL-38 as novel anti-inflammatory drugs has not been considered adequately. Here, we review the key properties of the IL-1 family members and provide insights into targeting or promoting select cytokines as new therapeutic agents." @default.
• W3047193582 created "2020-08-10" @default.
• W3047193582 creator A5038069974 @default.
• W3047193582 creator A5044256205 @default.
• W3047193582 creator A5054106836 @default.
• W3047193582 creator A5089527101 @default.
• W3047193582 creator A5091642258 @default.
• W3047193582 date "2020-08-06" @default.
• W3047193582 modified "2023-10-18" @default.
• W3047193582 title "IL-1 Superfamily Members and Periodontal Diseases" @default.
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• W3047193582 doi "https://doi.org/10.1177/0022034520945209" @default.

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