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- W3047210528 abstract "Physical frailty and sarcopenia (PF&S) recapitulates all the hallmarks of aging and has become a focus in geroscience. Factors spanning muscle-specific processes (e.g., mitochondrial dysfunction in skeletal myocytes) to systemic changes (e.g., inflammation and amino acid dysmetabolism) have been pinpointed as possible contributors to PF&S pathophysiology. However, the search for PF&S biomarkers allowing the early identification and tracking of the condition over time is ongoing. This is mainly due to the phenotypic heterogeneity of PF&S, its unclear pathophysiology, and the frequent superimposition of other age-related conditions. Hence, presently, the identification of PF&S relies upon clinical, functional, and imaging parameters. The adoption of multi-marker approaches (combined with multivariate modeling) has shown great potential for addressing the complexity of PF&S pathophysiology and identifying candidate biological markers. Well-designed longitudinal studies are necessary for the incorporation of reliable biomarkers into clinical practice and for unveiling novel targets that are amenable to interventions." @default.
- W3047210528 created "2020-08-10" @default.
- W3047210528 creator A5001960093 @default.
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- W3047210528 creator A5061789219 @default.
- W3047210528 date "2020-08-06" @default.
- W3047210528 modified "2023-10-14" @default.
- W3047210528 title "Biomarkers of Physical Frailty and Sarcopenia: Coming up to the Place?" @default.
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