FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047216908> ?p ?o ?g. }

• W3047216908 endingPage "2353" @default.
• W3047216908 startingPage "2353" @default.
• W3047216908 abstract "Non-alcoholic steatosis and insulin resistance are critical health problems and cause metabolic complications worldwide. In this study, we investigated the molecular mechanism of Polygonum multiflorum Thunb. (PM) against hepatic lipid accumulation and insulin resistance by using in vitro and in vivo models. PM extract significantly attenuated the accumulation of lipid droplets and hepatic triglyceride in free fatty acid (FFA)-exposed HepG2 cells. PM extract increased the AMPK and ACC phosphorylation and GLUT4 expression, whose levels were downregulated in FFA-exposed cells. PM extract also decreased precursor and mature forms of SREBP-1 in FFA-exposed cells. C57BL/6 mice fed with normal diet (ND) or high-fat diet (HFD) were administered PM extract (100 mg/kg) or vehicle orally for 16 weeks. PM extract attenuated the increases of the epididymal and perirenal fats on HFD feeding. PM extract markedly reduced hepatic lipid accumulation and fasting glucose levels, and improved glucose and insulin sensitivity in HFD-fed mice. HFD-fed mice decreased the AMPK and ACC phosphorylation and GLUT4 expression, and increased precursor and mature forms of SREBP-1; these changes were significantly restored by PM extract. In conclusion, PM extract alleviates non-alcoholic steatosis and insulin resistance through modulating the expression of proteins on lipid metabolism and glucose transport in the liver." @default.
• W3047216908 created "2020-08-10" @default.
• W3047216908 creator A5022338359 @default.
• W3047216908 creator A5027088400 @default.
• W3047216908 creator A5031681266 @default.
• W3047216908 creator A5044609643 @default.
• W3047216908 creator A5065535194 @default.
• W3047216908 creator A5076554629 @default.
• W3047216908 date "2020-08-06" @default.
• W3047216908 modified "2023-10-03" @default.
• W3047216908 title "The Root of Polygonum multiflorum Thunb. Alleviates Non-Alcoholic Steatosis and Insulin Resistance in High Fat Diet-Fed Mice" @default.
• W3047216908 cites W1491571904 @default.
• W3047216908 cites W1914169609 @default.
• W3047216908 cites W1966336914 @default.
• W3047216908 cites W1967667786 @default.
• W3047216908 cites W1985592156 @default.
• W3047216908 cites W1991386892 @default.
• W3047216908 cites W2000050828 @default.
• W3047216908 cites W2011574523 @default.
• W3047216908 cites W2023536393 @default.
• W3047216908 cites W2028250360 @default.
• W3047216908 cites W2036678616 @default.
• W3047216908 cites W2039903987 @default.
• W3047216908 cites W2042468825 @default.
• W3047216908 cites W2043564585 @default.
• W3047216908 cites W2056533726 @default.
• W3047216908 cites W2056728315 @default.
• W3047216908 cites W2059431819 @default.
• W3047216908 cites W2065854487 @default.
• W3047216908 cites W2069695193 @default.
• W3047216908 cites W2078374645 @default.
• W3047216908 cites W2084035112 @default.
• W3047216908 cites W2103052169 @default.
• W3047216908 cites W2103454092 @default.
• W3047216908 cites W2120385990 @default.
• W3047216908 cites W2132406938 @default.
• W3047216908 cites W2142272708 @default.
• W3047216908 cites W2143642040 @default.
• W3047216908 cites W2168829121 @default.
• W3047216908 cites W2179639615 @default.
• W3047216908 cites W2204688218 @default.
• W3047216908 cites W2483622726 @default.
• W3047216908 cites W2515136255 @default.
• W3047216908 cites W2568197147 @default.
• W3047216908 cites W2755198076 @default.
• W3047216908 cites W2763871199 @default.
• W3047216908 cites W2793203938 @default.
• W3047216908 cites W2802937446 @default.
• W3047216908 cites W2810629608 @default.
• W3047216908 cites W2879353630 @default.
• W3047216908 cites W2952380779 @default.
• W3047216908 cites W3001528811 @default.
• W3047216908 doi "https://doi.org/10.3390/nu12082353" @default.
• W3047216908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7468938" @default.
• W3047216908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32781739" @default.
• W3047216908 hasPublicationYear "2020" @default.
• W3047216908 type Work @default.
• W3047216908 sameAs 3047216908 @default.
• W3047216908 citedByCount "8" @default.
• W3047216908 countsByYear W30472169082021 @default.
• W3047216908 countsByYear W30472169082022 @default.
• W3047216908 countsByYear W30472169082023 @default.
• W3047216908 crossrefType "journal-article" @default.
• W3047216908 hasAuthorship W3047216908A5022338359 @default.
• W3047216908 hasAuthorship W3047216908A5027088400 @default.
• W3047216908 hasAuthorship W3047216908A5031681266 @default.
• W3047216908 hasAuthorship W3047216908A5044609643 @default.
• W3047216908 hasAuthorship W3047216908A5065535194 @default.
• W3047216908 hasAuthorship W3047216908A5076554629 @default.
• W3047216908 hasBestOaLocation W30472169081 @default.
• W3047216908 hasConcept C11960822 @default.
• W3047216908 hasConcept C126322002 @default.
• W3047216908 hasConcept C134018914 @default.
• W3047216908 hasConcept C17093226 @default.
• W3047216908 hasConcept C185592680 @default.
• W3047216908 hasConcept C18903297 @default.
• W3047216908 hasConcept C2776077704 @default.
• W3047216908 hasConcept C2776175330 @default.
• W3047216908 hasConcept C2776188179 @default.
• W3047216908 hasConcept C2777391703 @default.
• W3047216908 hasConcept C2778163477 @default.
• W3047216908 hasConcept C2778772119 @default.
• W3047216908 hasConcept C2778913445 @default.
• W3047216908 hasConcept C2779134260 @default.
• W3047216908 hasConcept C2779306644 @default.
• W3047216908 hasConcept C2780124434 @default.
• W3047216908 hasConcept C4733338 @default.
• W3047216908 hasConcept C55493867 @default.
• W3047216908 hasConcept C71924100 @default.
• W3047216908 hasConcept C86803240 @default.
• W3047216908 hasConcept C97029542 @default.
• W3047216908 hasConceptScore W3047216908C11960822 @default.
• W3047216908 hasConceptScore W3047216908C126322002 @default.
• W3047216908 hasConceptScore W3047216908C134018914 @default.
• W3047216908 hasConceptScore W3047216908C17093226 @default.
• W3047216908 hasConceptScore W3047216908C185592680 @default.
• W3047216908 hasConceptScore W3047216908C18903297 @default.
• W3047216908 hasConceptScore W3047216908C2776077704 @default.

• next