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• W3047243604 abstract "Abstract Background The aim of this study was to investigate the usefulness of the range of change in prognostic nutritional index (PNI) during the early postoperative period as a predictor of postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy. Methods Data were retrospectively analyzed for 192 patients who underwent pancreaticoduodenectomy. Univariate and multivariate logistic regression analyses were used to evaluate perioperative variables. PNI P3-Pre ratio represented the range of change in PNI from before surgery to postoperative day (POD) 3, PNI P1-Pre ratio represented the range of change in PNI from before surgery to POD 1, and PNI P3-P1 ratio represented the range of change in PNI from POD 1 to POD 3. Results The area under the curve (AUC) for PNI P3-P1 for prediction of POPF following pancreaticoduodenectomy was 0.683 ( P < 0.001), which was highest among PNI ratios and higher than PNI on POD 3. The AUC for serum amylase level on POD 1 was 0.704 ( P < 0.001), which was superior to the corresponding AUC on POD 3. The AUC for the combination of PNI P3-P1 ratio and serum amylase level on POD 1 for prediction of POPF was higher than the AUC of either indicator alone (0.743, P < 0.001). The combination of PNI P3-P1 ratio and serum amylase level on POD 1 was an independent predictor of POPF following pancreaticoduodenectomy ( P = 0.018). Conclusions The combination of the range of change in PNI from POD 1 to POD 3 and serum amylase levels on POD 1 may be useful for prediction of POPF following pancreaticoduodenectomy." @default.
• W3047243604 created "2020-08-10" @default.
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• W3047243604 date "2020-08-06" @default.
• W3047243604 modified "2023-10-16" @default.
• W3047243604 title "Combined prognostic nutritional index ratio and serum amylase level during the early postoperative period predicts pancreatic fistula following pancreaticoduodenectomy" @default.
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• W3047243604 doi "https://doi.org/10.1186/s12893-020-00838-0" @default.
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