FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047246901> ?p ?o ?g. }

• W3047246901 endingPage "14" @default.
• W3047246901 startingPage "1" @default.
• W3047246901 abstract "There remain few data about the role of homeostatic compaction in hepatic polarization. A previous study has found that mechanical compaction can accelerate hepatocyte polarization; however, the cellular mechanism underlying the effect is mostly unclear. Hepatocyte nuclear factor 4 alpha (HNF4 α ) is crucial for hepatic polarization in liver morphogenesis. Therefore, we sought to identify any possible involvement of HNF4 α in the process of hepatocyte polarization accelerated by mechanical compaction. We first verified in the nonhepatic cell model HEK-293T, and the hepatic cell model primary hepatocytes that the mechanical compaction on cell aggregates simulated by using transient centrifugation can directly activate the expression of HNF4 α promoters. Moreover, data using primary hepatocytes showed that the HNF4 α expression is positively associated with the levels of compaction force: 2.1-folds higher at the mRNA level and 2.1-folds higher at the protein level for 500 g vs. 0 g. Furthermore, activated HNF4 α expression is associated with the enhanced biliary canalicular formation and the increased production of albumin and urea. Pretreatment with Latrunculin B, an inhibitor of F-actin, and SHE78-7, an inhibitor of E-cadherin, which both interrupt the pathway of mechanical transduction, partially but significantly reduced the HNF4 α expression and production of albumin and urea. In conclusion, HNF4 α can be actively involved in the hepatic polarization in the context of environmental mechanical compaction." @default.
• W3047246901 created "2020-08-10" @default.
• W3047246901 creator A5003642180 @default.
• W3047246901 creator A5012462752 @default.
• W3047246901 creator A5021744789 @default.
• W3047246901 creator A5037824478 @default.
• W3047246901 creator A5037834945 @default.
• W3047246901 creator A5039567363 @default.
• W3047246901 creator A5064842058 @default.
• W3047246901 creator A5068284208 @default.
• W3047246901 creator A5074188932 @default.
• W3047246901 creator A5077554032 @default.
• W3047246901 creator A5085896312 @default.
• W3047246901 creator A5090283553 @default.
• W3047246901 date "2020-08-05" @default.
• W3047246901 modified "2023-10-17" @default.
• W3047246901 title "Hepatic Polarization Accelerated by Mechanical Compaction Involves HNF4α Activation" @default.
• W3047246901 cites W107605208 @default.
• W3047246901 cites W1964585722 @default.
• W3047246901 cites W1979978944 @default.
• W3047246901 cites W1984653721 @default.
• W3047246901 cites W1991031928 @default.
• W3047246901 cites W1992424188 @default.
• W3047246901 cites W1993763232 @default.
• W3047246901 cites W1995448152 @default.
• W3047246901 cites W2004578186 @default.
• W3047246901 cites W2006393800 @default.
• W3047246901 cites W2013158875 @default.
• W3047246901 cites W2029497594 @default.
• W3047246901 cites W2034035825 @default.
• W3047246901 cites W2038747312 @default.
• W3047246901 cites W2046786093 @default.
• W3047246901 cites W2051890243 @default.
• W3047246901 cites W2060474798 @default.
• W3047246901 cites W2066021878 @default.
• W3047246901 cites W2080708750 @default.
• W3047246901 cites W2081896863 @default.
• W3047246901 cites W2084132599 @default.
• W3047246901 cites W2095690799 @default.
• W3047246901 cites W2113189847 @default.
• W3047246901 cites W2115758207 @default.
• W3047246901 cites W2122496801 @default.
• W3047246901 cites W2134408039 @default.
• W3047246901 cites W2151103961 @default.
• W3047246901 cites W2153988264 @default.
• W3047246901 cites W2164803358 @default.
• W3047246901 cites W2165747522 @default.
• W3047246901 cites W2166941387 @default.
• W3047246901 cites W2277807021 @default.
• W3047246901 cites W2514654033 @default.
• W3047246901 cites W2558581266 @default.
• W3047246901 cites W2576822117 @default.
• W3047246901 cites W2884807148 @default.
• W3047246901 cites W3010322897 @default.
• W3047246901 cites W4211245332 @default.
• W3047246901 cites W4294235499 @default.
• W3047246901 cites W871087567 @default.
• W3047246901 doi "https://doi.org/10.1155/2020/8016306" @default.
• W3047246901 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7426769" @default.
• W3047246901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32802875" @default.
• W3047246901 hasPublicationYear "2020" @default.
• W3047246901 type Work @default.
• W3047246901 sameAs 3047246901 @default.
• W3047246901 citedByCount "0" @default.
• W3047246901 crossrefType "journal-article" @default.
• W3047246901 hasAuthorship W3047246901A5003642180 @default.
• W3047246901 hasAuthorship W3047246901A5012462752 @default.
• W3047246901 hasAuthorship W3047246901A5021744789 @default.
• W3047246901 hasAuthorship W3047246901A5037824478 @default.
• W3047246901 hasAuthorship W3047246901A5037834945 @default.
• W3047246901 hasAuthorship W3047246901A5039567363 @default.
• W3047246901 hasAuthorship W3047246901A5064842058 @default.
• W3047246901 hasAuthorship W3047246901A5068284208 @default.
• W3047246901 hasAuthorship W3047246901A5074188932 @default.
• W3047246901 hasAuthorship W3047246901A5077554032 @default.
• W3047246901 hasAuthorship W3047246901A5085896312 @default.
• W3047246901 hasAuthorship W3047246901A5090283553 @default.
• W3047246901 hasBestOaLocation W30472469011 @default.
• W3047246901 hasConcept C104317684 @default.
• W3047246901 hasConcept C12554922 @default.
• W3047246901 hasConcept C159985019 @default.
• W3047246901 hasConcept C185592680 @default.
• W3047246901 hasConcept C192562407 @default.
• W3047246901 hasConcept C196715460 @default.
• W3047246901 hasConcept C202751555 @default.
• W3047246901 hasConcept C2776200302 @default.
• W3047246901 hasConcept C55493867 @default.
• W3047246901 hasConcept C63932345 @default.
• W3047246901 hasConcept C72699923 @default.
• W3047246901 hasConcept C86339819 @default.
• W3047246901 hasConcept C86803240 @default.
• W3047246901 hasConcept C95444343 @default.
• W3047246901 hasConceptScore W3047246901C104317684 @default.
• W3047246901 hasConceptScore W3047246901C12554922 @default.
• W3047246901 hasConceptScore W3047246901C159985019 @default.
• W3047246901 hasConceptScore W3047246901C185592680 @default.
• W3047246901 hasConceptScore W3047246901C192562407 @default.
• W3047246901 hasConceptScore W3047246901C196715460 @default.

• next