Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047262309> ?p ?o ?g. }
- W3047262309 endingPage "7024" @default.
- W3047262309 startingPage "7009" @default.
- W3047262309 abstract "Dithiolanes are used to obtain dynamic and reversible crosslinks between polymer chains. Copolymers of two different dithiolane-containing cyclic carbonate monomers and ε-caprolactone (CL) were synthesized by ring-opening polymerization using a methoxy-poly(ethylene glycol) (mPEG) initiator and different catalysts (diphenyl phosphate (DPP), methanesulfonic acid (MSA), 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD), or Sn(Oct)2). Each catalyst required a different temperature, which had a pronounced influence on the reactivity ratio of the monomers and occurrence of transesterification reactions and, therefore, the monomer sequence. Self-crosslinkable copolymers were obtained when the dithiolane units were connected closely to the polymer backbone, whereas the presence of a linker unit between the dithiolane and the backbone prevented self-crosslinking. The former amphiphilic PEGylated block copolymers formed micelles by nanoprecipitation in the aqueous environment and crosslinked spontaneously by disulfide exchange during subsequent dialysis. These dithiolane-crosslinked micelles showed reduction-responsive dissociation in the presence of 10 mM glutathione, making them promising drug delivery systems for the intracellularly triggered cargo release." @default.
- W3047262309 created "2020-08-10" @default.
- W3047262309 creator A5000727625 @default.
- W3047262309 creator A5002804492 @default.
- W3047262309 creator A5008208885 @default.
- W3047262309 creator A5017735982 @default.
- W3047262309 creator A5039037778 @default.
- W3047262309 creator A5051906887 @default.
- W3047262309 date "2020-08-03" @default.
- W3047262309 modified "2023-10-03" @default.
- W3047262309 title "Dithiolane-Crosslinked Poly(ε-caprolactone)-Based Micelles: Impact of Monomer Sequence, Nature of Monomer, and Reducing Agent on the Dynamic Crosslinking Properties" @default.
- W3047262309 cites W1495482938 @default.
- W3047262309 cites W1944506335 @default.
- W3047262309 cites W1963861876 @default.
- W3047262309 cites W1966854906 @default.
- W3047262309 cites W1967950694 @default.
- W3047262309 cites W1968583232 @default.
- W3047262309 cites W1976041621 @default.
- W3047262309 cites W1983508787 @default.
- W3047262309 cites W1987406340 @default.
- W3047262309 cites W1989036661 @default.
- W3047262309 cites W1992258152 @default.
- W3047262309 cites W1995008606 @default.
- W3047262309 cites W1996051333 @default.
- W3047262309 cites W2001624022 @default.
- W3047262309 cites W2003730544 @default.
- W3047262309 cites W2004350652 @default.
- W3047262309 cites W2012596484 @default.
- W3047262309 cites W2013765163 @default.
- W3047262309 cites W2016083698 @default.
- W3047262309 cites W2016205995 @default.
- W3047262309 cites W2017315930 @default.
- W3047262309 cites W2019081161 @default.
- W3047262309 cites W2024213264 @default.
- W3047262309 cites W2032760352 @default.
- W3047262309 cites W2032965857 @default.
- W3047262309 cites W2034387102 @default.
- W3047262309 cites W2037365087 @default.
- W3047262309 cites W2049930363 @default.
- W3047262309 cites W2053958243 @default.
- W3047262309 cites W2054688174 @default.
- W3047262309 cites W2065641319 @default.
- W3047262309 cites W2066061791 @default.
- W3047262309 cites W2070366616 @default.
- W3047262309 cites W2076434014 @default.
- W3047262309 cites W2077964613 @default.
- W3047262309 cites W2079038224 @default.
- W3047262309 cites W2089658062 @default.
- W3047262309 cites W2095405145 @default.
- W3047262309 cites W2095597293 @default.
- W3047262309 cites W2099668627 @default.
- W3047262309 cites W2109772863 @default.
- W3047262309 cites W2121171143 @default.
- W3047262309 cites W2121588632 @default.
- W3047262309 cites W2137634849 @default.
- W3047262309 cites W2146066038 @default.
- W3047262309 cites W2155604981 @default.
- W3047262309 cites W2156694810 @default.
- W3047262309 cites W2158921195 @default.
- W3047262309 cites W2252957247 @default.
- W3047262309 cites W2325801570 @default.
- W3047262309 cites W2334832038 @default.
- W3047262309 cites W2404508991 @default.
- W3047262309 cites W2474056317 @default.
- W3047262309 cites W2511899351 @default.
- W3047262309 cites W2561431412 @default.
- W3047262309 cites W2587929901 @default.
- W3047262309 cites W2593488075 @default.
- W3047262309 cites W2610410417 @default.
- W3047262309 cites W2727226489 @default.
- W3047262309 cites W2756602305 @default.
- W3047262309 cites W2760534696 @default.
- W3047262309 cites W2764045342 @default.
- W3047262309 cites W2765813053 @default.
- W3047262309 cites W2778216804 @default.
- W3047262309 cites W2799374027 @default.
- W3047262309 cites W2900595575 @default.
- W3047262309 doi "https://doi.org/10.1021/acs.macromol.0c01031" @default.
- W3047262309 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7458473" @default.
- W3047262309 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32884159" @default.
- W3047262309 hasPublicationYear "2020" @default.
- W3047262309 type Work @default.
- W3047262309 sameAs 3047262309 @default.
- W3047262309 citedByCount "13" @default.
- W3047262309 countsByYear W30472623092020 @default.
- W3047262309 countsByYear W30472623092021 @default.
- W3047262309 countsByYear W30472623092022 @default.
- W3047262309 countsByYear W30472623092023 @default.
- W3047262309 crossrefType "journal-article" @default.
- W3047262309 hasAuthorship W3047262309A5000727625 @default.
- W3047262309 hasAuthorship W3047262309A5002804492 @default.
- W3047262309 hasAuthorship W3047262309A5008208885 @default.
- W3047262309 hasAuthorship W3047262309A5017735982 @default.
- W3047262309 hasAuthorship W3047262309A5039037778 @default.
- W3047262309 hasAuthorship W3047262309A5051906887 @default.
- W3047262309 hasBestOaLocation W30472623091 @default.
- W3047262309 hasConcept C11268172 @default.
- W3047262309 hasConcept C15920480 @default.