FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047285890> ?p ?o ?g. }

• W3047285890 abstract "The fibroblast growth factor family polypeptides play key roles in promoting tissue regeneration and repair. FGF5 is strongly up-regulated in Schwann cells of the peripheral nervous system following injury; however a role for FGF5 in peripheral nerve regeneration has not been shown up to now. In this report, we examined the expression of FGF5 and its receptors FGFR1-4 in Schwann cells of the mouse sciatic nerve following injury, and then measured the effects of FGF5 treatment upon cultured primary rat Schwann cells. By microarray and mRNA sequencing data analysis, RT-PCR, qPCR, western blotting and immunostaining, we show that FGF5 is highly up-regulated in Schwann cells of the mouse distal sciatic nerve following injury, and FGFR1 and FGFR2 are highly expressed in Schwann cells of the peripheral nerve both before and following injury. Using cultured primary rat Schwann cells, we show that FGF5 inhibits ERK1/2 MAP kinase activity but promotes rapid Schwann cell migration and adhesion via the upregulation of N-cadherin. Thus, FGF5 is an autocrine regulator of Schwann cells to regulate Schwann cell migration and adhesion." @default.
• W3047285890 created "2020-08-10" @default.
• W3047285890 creator A5062361716 @default.
• W3047285890 creator A5074870071 @default.
• W3047285890 creator A5077604881 @default.
• W3047285890 creator A5078980050 @default.
• W3047285890 creator A5080657266 @default.
• W3047285890 creator A5091737949 @default.
• W3047285890 date "2020-08-04" @default.
• W3047285890 modified "2023-10-16" @default.
• W3047285890 title "FGF5 Regulates Schwann Cell Migration and Adhesion" @default.
• W3047285890 cites W1637502338 @default.
• W3047285890 cites W1784257340 @default.
• W3047285890 cites W1901870712 @default.
• W3047285890 cites W1922410518 @default.
• W3047285890 cites W1922994157 @default.
• W3047285890 cites W1935201742 @default.
• W3047285890 cites W1962474309 @default.
• W3047285890 cites W1968431306 @default.
• W3047285890 cites W1971275183 @default.
• W3047285890 cites W1971468831 @default.
• W3047285890 cites W1988269444 @default.
• W3047285890 cites W1988544634 @default.
• W3047285890 cites W2005200443 @default.
• W3047285890 cites W2011101502 @default.
• W3047285890 cites W2015153349 @default.
• W3047285890 cites W2015768569 @default.
• W3047285890 cites W2023479137 @default.
• W3047285890 cites W2027239974 @default.
• W3047285890 cites W2033370405 @default.
• W3047285890 cites W2050935187 @default.
• W3047285890 cites W2054195724 @default.
• W3047285890 cites W2056016311 @default.
• W3047285890 cites W2056574662 @default.
• W3047285890 cites W2071594454 @default.
• W3047285890 cites W2074524000 @default.
• W3047285890 cites W2085779749 @default.
• W3047285890 cites W2090653319 @default.
• W3047285890 cites W2095842738 @default.
• W3047285890 cites W2107277218 @default.
• W3047285890 cites W2108545233 @default.
• W3047285890 cites W2110378444 @default.
• W3047285890 cites W2116587859 @default.
• W3047285890 cites W2119743841 @default.
• W3047285890 cites W2124697955 @default.
• W3047285890 cites W2133942047 @default.
• W3047285890 cites W2135007468 @default.
• W3047285890 cites W2148316753 @default.
• W3047285890 cites W2149922101 @default.
• W3047285890 cites W2168389928 @default.
• W3047285890 cites W2190613893 @default.
• W3047285890 cites W2192080449 @default.
• W3047285890 cites W2203577167 @default.
• W3047285890 cites W2404457298 @default.
• W3047285890 cites W2418169592 @default.
• W3047285890 cites W2444407689 @default.
• W3047285890 cites W2460917892 @default.
• W3047285890 cites W2464410938 @default.
• W3047285890 cites W2509868811 @default.
• W3047285890 cites W2532027072 @default.
• W3047285890 cites W2589145912 @default.
• W3047285890 cites W2606947801 @default.
• W3047285890 cites W2659865712 @default.
• W3047285890 cites W2739171987 @default.
• W3047285890 cites W2741185523 @default.
• W3047285890 cites W2759539358 @default.
• W3047285890 cites W2760801028 @default.
• W3047285890 cites W2768102825 @default.
• W3047285890 cites W2783115864 @default.
• W3047285890 cites W2793346386 @default.
• W3047285890 cites W2795059381 @default.
• W3047285890 cites W2899695506 @default.
• W3047285890 cites W2913784856 @default.
• W3047285890 cites W2917901234 @default.
• W3047285890 cites W2946109418 @default.
• W3047285890 cites W2950061252 @default.
• W3047285890 cites W2972505478 @default.
• W3047285890 cites W2974470952 @default.
• W3047285890 cites W2992450083 @default.
• W3047285890 cites W350218092 @default.
• W3047285890 cites W4232061733 @default.
• W3047285890 doi "https://doi.org/10.3389/fncel.2020.00237" @default.
• W3047285890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7417478" @default.
• W3047285890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32848626" @default.
• W3047285890 hasPublicationYear "2020" @default.
• W3047285890 type Work @default.
• W3047285890 sameAs 3047285890 @default.
• W3047285890 citedByCount "13" @default.
• W3047285890 countsByYear W30472858902021 @default.
• W3047285890 countsByYear W30472858902022 @default.
• W3047285890 countsByYear W30472858902023 @default.
• W3047285890 crossrefType "journal-article" @default.
• W3047285890 hasAuthorship W3047285890A5062361716 @default.
• W3047285890 hasAuthorship W3047285890A5074870071 @default.
• W3047285890 hasAuthorship W3047285890A5077604881 @default.
• W3047285890 hasAuthorship W3047285890A5078980050 @default.
• W3047285890 hasAuthorship W3047285890A5080657266 @default.
• W3047285890 hasAuthorship W3047285890A5091737949 @default.
• W3047285890 hasBestOaLocation W30472858901 @default.
• W3047285890 hasConcept C105702510 @default.

• next