FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047314257> ?p ?o ?g. }

• W3047314257 endingPage "9612" @default.
• W3047314257 startingPage "9605" @default.
• W3047314257 abstract "Abstract Osteonecrosis of the femoral head (ONFH) is a progressive, obstinate and disabling disease. At present, the treatment of ONFH is still a global medical problem. We aim to explore the role of bone mesenchymal stem cells (BMSCs)‐derived and siRNAs‐encapsulated exosomes (siRNAs‐encapsulated BMSCexos) in ONFH. We first isolated BMSCexos and screened siRNAs of 6 ONFH‐related genes for siRNAs‐encapsulated BMSCexo. The expression of these 6 ONFH‐related genes in dexamethasone (DXM)‐treated MC3T3‐E1 cell, cell model of ONFH, was detected by RT‐qPCR and Western blot analysis. And then, we performed CCK‐8 assay, angiogenesis assay and HE staining analysis to test the promotion role of the siRNAs‐encapsulated BMSCexo for angiogenesis during ONFH repair. The results suggest that the obtained particles were BMSCexos. The screened effective siRNAs could effectively knock down their expression in VECs. Moreover, siRNAs‐encapsulated BMSCexo could effectively knock down the expression of these genes in VECs. In addition, siRNAs‐encapsulated BMSCexo promote angiogenesis during ONFH repair. In conclusion, we found siRNAs‐encapsulated BMSCexos could promote ONFH repair by angiogenesis, and indicated exosome as the new siRNA carrier is of great significance to improve the efficiency of RNAi." @default.
• W3047314257 created "2020-08-10" @default.
• W3047314257 creator A5003189864 @default.
• W3047314257 creator A5008987451 @default.
• W3047314257 creator A5010755399 @default.
• W3047314257 creator A5026328793 @default.
• W3047314257 creator A5034028862 @default.
• W3047314257 creator A5038764555 @default.
• W3047314257 date "2020-08-04" @default.
• W3047314257 modified "2023-09-24" @default.
• W3047314257 title "Mesenchymal stem cells‐derived and siRNAs‐encapsulated exosomes inhibit osteonecrosis of the femoral head" @default.
• W3047314257 cites W1596481474 @default.
• W3047314257 cites W17178022 @default.
• W3047314257 cites W1796320688 @default.
• W3047314257 cites W1994948303 @default.
• W3047314257 cites W1995423147 @default.
• W3047314257 cites W2020863352 @default.
• W3047314257 cites W2020992406 @default.
• W3047314257 cites W2029622887 @default.
• W3047314257 cites W2051931680 @default.
• W3047314257 cites W2054939463 @default.
• W3047314257 cites W2057356848 @default.
• W3047314257 cites W2066234893 @default.
• W3047314257 cites W2066843867 @default.
• W3047314257 cites W2070070981 @default.
• W3047314257 cites W2071625709 @default.
• W3047314257 cites W2072373487 @default.
• W3047314257 cites W2080196370 @default.
• W3047314257 cites W2122487966 @default.
• W3047314257 cites W2154830836 @default.
• W3047314257 cites W2168622467 @default.
• W3047314257 cites W2404007660 @default.
• W3047314257 cites W2441712629 @default.
• W3047314257 cites W2757451466 @default.
• W3047314257 cites W2783857686 @default.
• W3047314257 cites W2789893810 @default.
• W3047314257 cites W2789974909 @default.
• W3047314257 cites W2802635773 @default.
• W3047314257 cites W2809723856 @default.
• W3047314257 cites W2899080211 @default.
• W3047314257 cites W2941080791 @default.
• W3047314257 cites W2942387017 @default.
• W3047314257 cites W2987480750 @default.
• W3047314257 cites W2996743659 @default.
• W3047314257 cites W4253432485 @default.
• W3047314257 doi "https://doi.org/10.1111/jcmm.15395" @default.
• W3047314257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7520260" @default.
• W3047314257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32749049" @default.
• W3047314257 hasPublicationYear "2020" @default.
• W3047314257 type Work @default.
• W3047314257 sameAs 3047314257 @default.
• W3047314257 citedByCount "6" @default.
• W3047314257 countsByYear W30473142572022 @default.
• W3047314257 countsByYear W30473142572023 @default.
• W3047314257 crossrefType "journal-article" @default.
• W3047314257 hasAuthorship W3047314257A5003189864 @default.
• W3047314257 hasAuthorship W3047314257A5008987451 @default.
• W3047314257 hasAuthorship W3047314257A5010755399 @default.
• W3047314257 hasAuthorship W3047314257A5026328793 @default.
• W3047314257 hasAuthorship W3047314257A5034028862 @default.
• W3047314257 hasAuthorship W3047314257A5038764555 @default.
• W3047314257 hasBestOaLocation W30473142571 @default.
• W3047314257 hasConcept C104317684 @default.
• W3047314257 hasConcept C145059251 @default.
• W3047314257 hasConcept C1491633281 @default.
• W3047314257 hasConcept C166703698 @default.
• W3047314257 hasConcept C198826908 @default.
• W3047314257 hasConcept C20518536 @default.
• W3047314257 hasConcept C22615655 @default.
• W3047314257 hasConcept C2780394083 @default.
• W3047314257 hasConcept C2781261824 @default.
• W3047314257 hasConcept C502942594 @default.
• W3047314257 hasConcept C54009773 @default.
• W3047314257 hasConcept C54355233 @default.
• W3047314257 hasConcept C67705224 @default.
• W3047314257 hasConcept C71924100 @default.
• W3047314257 hasConcept C81885089 @default.
• W3047314257 hasConcept C86803240 @default.
• W3047314257 hasConcept C95444343 @default.
• W3047314257 hasConceptScore W3047314257C104317684 @default.
• W3047314257 hasConceptScore W3047314257C145059251 @default.
• W3047314257 hasConceptScore W3047314257C1491633281 @default.
• W3047314257 hasConceptScore W3047314257C166703698 @default.
• W3047314257 hasConceptScore W3047314257C198826908 @default.
• W3047314257 hasConceptScore W3047314257C20518536 @default.
• W3047314257 hasConceptScore W3047314257C22615655 @default.
• W3047314257 hasConceptScore W3047314257C2780394083 @default.
• W3047314257 hasConceptScore W3047314257C2781261824 @default.
• W3047314257 hasConceptScore W3047314257C502942594 @default.
• W3047314257 hasConceptScore W3047314257C54009773 @default.
• W3047314257 hasConceptScore W3047314257C54355233 @default.
• W3047314257 hasConceptScore W3047314257C67705224 @default.
• W3047314257 hasConceptScore W3047314257C71924100 @default.
• W3047314257 hasConceptScore W3047314257C81885089 @default.
• W3047314257 hasConceptScore W3047314257C86803240 @default.
• W3047314257 hasConceptScore W3047314257C95444343 @default.
• W3047314257 hasFunder F4320321001 @default.
• W3047314257 hasIssue "17" @default.

• next