FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047314652> ?p ?o ?g. }

• W3047314652 abstract "Abstract Modern technologies such as 16s DNA sequencing capable of identifying microbes and provide taxonomic resolution at species and strain-specific levels is destined to be transformative 1 . Likewise, there is an emerging need to accurately identify both infectious and non-infectious microbes non-invasively in the body at the genus and species level to guide diagnosis and treatment strategies. Here, we report development of radiometal-labelled bacterial chelators, knowns as metallophores that allow non-invasive and selective imaging of bacteria and bacterial products in vivo . We show that these novel contrast agents are able to identify E. coli with strain level specificity and other bacteria, such as K. pneumoniae , based on expression of distinct cognate transporters on the bacterial surface. The probe is also capable of tracking probiotic, engineered bacteria and bacterial products, outer membrane vesicles (OMVs), in unique niches such as tumours. Moreover, we report that this novel targeted imaging approach has impactful applicability in monitoring antibiotic treatment outcomes in patients with pulmonary infections, thereby providing the ability to optimize individualized therapeutic approaches. Compared to traditional techniques used to manufacture probes, this strategy simplifies the process considerably by combining the function of metal attachment and cell recognition into a single molecule. Thus, we anticipate that these probes will be widely used in both clinical and investigative settings in living systems for non-invasive imaging of infectious and non-infectious organisms." @default.
• W3047314652 created "2020-08-10" @default.
• W3047314652 creator A5016266321 @default.
• W3047314652 creator A5019294398 @default.
• W3047314652 creator A5035891403 @default.
• W3047314652 creator A5040569387 @default.
• W3047314652 creator A5054150736 @default.
• W3047314652 creator A5067294261 @default.
• W3047314652 creator A5075304112 @default.
• W3047314652 creator A5080396335 @default.
• W3047314652 date "2020-08-06" @default.
• W3047314652 modified "2023-10-16" @default.
• W3047314652 title "Radiolabelled Bacterial Metallophores as Targeted PET Imaging Contrast Agents for Accurate Identification of Bacteria and Outer Membrane Vesicles in vivo" @default.
• W3047314652 cites W1595241211 @default.
• W3047314652 cites W1964138264 @default.
• W3047314652 cites W1966223820 @default.
• W3047314652 cites W1991279358 @default.
• W3047314652 cites W2014008119 @default.
• W3047314652 cites W2016136239 @default.
• W3047314652 cites W2019167109 @default.
• W3047314652 cites W2042490028 @default.
• W3047314652 cites W2052634607 @default.
• W3047314652 cites W2053469021 @default.
• W3047314652 cites W2060202201 @default.
• W3047314652 cites W2063884776 @default.
• W3047314652 cites W2069120014 @default.
• W3047314652 cites W2073924079 @default.
• W3047314652 cites W2075787499 @default.
• W3047314652 cites W2091587044 @default.
• W3047314652 cites W2094755933 @default.
• W3047314652 cites W2095511791 @default.
• W3047314652 cites W2103350224 @default.
• W3047314652 cites W2107225159 @default.
• W3047314652 cites W2117986752 @default.
• W3047314652 cites W2120237702 @default.
• W3047314652 cites W2137792756 @default.
• W3047314652 cites W2139040250 @default.
• W3047314652 cites W2140405265 @default.
• W3047314652 cites W2147157147 @default.
• W3047314652 cites W2148920499 @default.
• W3047314652 cites W2161548174 @default.
• W3047314652 cites W2167521476 @default.
• W3047314652 cites W2174939397 @default.
• W3047314652 cites W2403430327 @default.
• W3047314652 cites W2404883061 @default.
• W3047314652 cites W2550835414 @default.
• W3047314652 cites W2586223583 @default.
• W3047314652 cites W2735303761 @default.
• W3047314652 cites W2737678248 @default.
• W3047314652 cites W2755907882 @default.
• W3047314652 cites W2801685191 @default.
• W3047314652 cites W2803938554 @default.
• W3047314652 cites W2885474054 @default.
• W3047314652 cites W2885894788 @default.
• W3047314652 cites W2896710856 @default.
• W3047314652 cites W2898245218 @default.
• W3047314652 cites W2914274450 @default.
• W3047314652 cites W2920238929 @default.
• W3047314652 cites W2955245896 @default.
• W3047314652 cites W2971878379 @default.
• W3047314652 cites W2985711816 @default.
• W3047314652 cites W4241227411 @default.
• W3047314652 doi "https://doi.org/10.1101/2020.08.06.240119" @default.
• W3047314652 hasPublicationYear "2020" @default.
• W3047314652 type Work @default.
• W3047314652 sameAs 3047314652 @default.
• W3047314652 citedByCount "2" @default.
• W3047314652 countsByYear W30473146522021 @default.
• W3047314652 crossrefType "posted-content" @default.
• W3047314652 hasAuthorship W3047314652A5016266321 @default.
• W3047314652 hasAuthorship W3047314652A5019294398 @default.
• W3047314652 hasAuthorship W3047314652A5035891403 @default.
• W3047314652 hasAuthorship W3047314652A5040569387 @default.
• W3047314652 hasAuthorship W3047314652A5054150736 @default.
• W3047314652 hasAuthorship W3047314652A5067294261 @default.
• W3047314652 hasAuthorship W3047314652A5075304112 @default.
• W3047314652 hasAuthorship W3047314652A5080396335 @default.
• W3047314652 hasBestOaLocation W30473146521 @default.
• W3047314652 hasConcept C104317684 @default.
• W3047314652 hasConcept C146587185 @default.
• W3047314652 hasConcept C150903083 @default.
• W3047314652 hasConcept C207001950 @default.
• W3047314652 hasConcept C523546767 @default.
• W3047314652 hasConcept C54355233 @default.
• W3047314652 hasConcept C547475151 @default.
• W3047314652 hasConcept C55493867 @default.
• W3047314652 hasConcept C70721500 @default.
• W3047314652 hasConcept C86803240 @default.
• W3047314652 hasConcept C89423630 @default.
• W3047314652 hasConceptScore W3047314652C104317684 @default.
• W3047314652 hasConceptScore W3047314652C146587185 @default.
• W3047314652 hasConceptScore W3047314652C150903083 @default.
• W3047314652 hasConceptScore W3047314652C207001950 @default.
• W3047314652 hasConceptScore W3047314652C523546767 @default.
• W3047314652 hasConceptScore W3047314652C54355233 @default.
• W3047314652 hasConceptScore W3047314652C547475151 @default.
• W3047314652 hasConceptScore W3047314652C55493867 @default.
• W3047314652 hasConceptScore W3047314652C70721500 @default.
• W3047314652 hasConceptScore W3047314652C86803240 @default.
• W3047314652 hasConceptScore W3047314652C89423630 @default.

• next