Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047346089> ?p ?o ?g. }
- W3047346089 endingPage "181" @default.
- W3047346089 startingPage "165" @default.
- W3047346089 abstract "Abstract Unlike microglia and NG2 glia, astrocytes are incapable of migrating to sites of injury in the posttraumatic cerebral cortex, instead relying on proliferation to replenish their numbers and distribution in the affected region. However, neither the spectrum of their proliferative repertoire nor their postinjury distribution has been examined in vivo. Using a combination of different thymidine analogs and clonal analysis in a model of repetitive traumatic brain injury, we show for the first time that astrocytes that are quiescent following an initial injury can be coerced to proliferate after a repeated insult in the cerebral cortex grey matter. Interestingly, this process is promoted by invasion of monocytes to the injury site, as their genetic ablation (using CCR2 −/− mice) increased the number of repetitively dividing astrocytes at the expense of newly proliferating astrocytes in repeatedly injured parenchyma. These differences profoundly affected both the distribution of astrocytes and recovery period for posttraumatic behavior deficits suggesting key roles of astrocyte self‐renewal in brain repair after injury." @default.
- W3047346089 created "2020-08-10" @default.
- W3047346089 creator A5004830561 @default.
- W3047346089 creator A5006581643 @default.
- W3047346089 creator A5020991402 @default.
- W3047346089 creator A5031630803 @default.
- W3047346089 creator A5065977507 @default.
- W3047346089 creator A5072994313 @default.
- W3047346089 creator A5085113673 @default.
- W3047346089 date "2020-08-03" @default.
- W3047346089 modified "2023-10-16" @default.
- W3047346089 title "Repetitive injury and absence of monocytes promote astrocyte self‐renewal and neurological recovery" @default.
- W3047346089 cites W1140975977 @default.
- W3047346089 cites W1516434930 @default.
- W3047346089 cites W1517915273 @default.
- W3047346089 cites W1523922157 @default.
- W3047346089 cites W1530186493 @default.
- W3047346089 cites W1594747697 @default.
- W3047346089 cites W1965116070 @default.
- W3047346089 cites W1965495835 @default.
- W3047346089 cites W1967017576 @default.
- W3047346089 cites W1979552960 @default.
- W3047346089 cites W1983061009 @default.
- W3047346089 cites W1984527044 @default.
- W3047346089 cites W1993123483 @default.
- W3047346089 cites W1993678030 @default.
- W3047346089 cites W1998314033 @default.
- W3047346089 cites W2010980945 @default.
- W3047346089 cites W2020138925 @default.
- W3047346089 cites W2022224180 @default.
- W3047346089 cites W2023755606 @default.
- W3047346089 cites W2023760861 @default.
- W3047346089 cites W2025500109 @default.
- W3047346089 cites W2037564450 @default.
- W3047346089 cites W2038480095 @default.
- W3047346089 cites W2042335373 @default.
- W3047346089 cites W2042681276 @default.
- W3047346089 cites W2043439734 @default.
- W3047346089 cites W2043441080 @default.
- W3047346089 cites W2045421141 @default.
- W3047346089 cites W2047081899 @default.
- W3047346089 cites W2047647123 @default.
- W3047346089 cites W2054226892 @default.
- W3047346089 cites W2057332354 @default.
- W3047346089 cites W2059131332 @default.
- W3047346089 cites W2061330716 @default.
- W3047346089 cites W2064297038 @default.
- W3047346089 cites W2065746709 @default.
- W3047346089 cites W2070391037 @default.
- W3047346089 cites W2070652488 @default.
- W3047346089 cites W2072620393 @default.
- W3047346089 cites W2073390876 @default.
- W3047346089 cites W2075457027 @default.
- W3047346089 cites W2075808979 @default.
- W3047346089 cites W2076432328 @default.
- W3047346089 cites W2080932190 @default.
- W3047346089 cites W2081855022 @default.
- W3047346089 cites W2084772990 @default.
- W3047346089 cites W2090249462 @default.
- W3047346089 cites W2095490681 @default.
- W3047346089 cites W2097212923 @default.
- W3047346089 cites W2101667799 @default.
- W3047346089 cites W2103861118 @default.
- W3047346089 cites W2104003768 @default.
- W3047346089 cites W2106733186 @default.
- W3047346089 cites W2109503237 @default.
- W3047346089 cites W2117122511 @default.
- W3047346089 cites W2118661818 @default.
- W3047346089 cites W2122297603 @default.
- W3047346089 cites W2122494790 @default.
- W3047346089 cites W2124658196 @default.
- W3047346089 cites W2128229230 @default.
- W3047346089 cites W2129977027 @default.
- W3047346089 cites W2131369634 @default.
- W3047346089 cites W2131631451 @default.
- W3047346089 cites W2134896214 @default.
- W3047346089 cites W2135376726 @default.
- W3047346089 cites W2140178129 @default.
- W3047346089 cites W2152131288 @default.
- W3047346089 cites W2152793856 @default.
- W3047346089 cites W2153602569 @default.
- W3047346089 cites W2154072118 @default.
- W3047346089 cites W2154592820 @default.
- W3047346089 cites W2168767889 @default.
- W3047346089 cites W2168901267 @default.
- W3047346089 cites W2176412441 @default.
- W3047346089 cites W2181278247 @default.
- W3047346089 cites W2181835826 @default.
- W3047346089 cites W2186638283 @default.
- W3047346089 cites W2198623424 @default.
- W3047346089 cites W2293879687 @default.
- W3047346089 cites W2335534790 @default.
- W3047346089 cites W2469873988 @default.
- W3047346089 cites W2559702793 @default.
- W3047346089 cites W2586662902 @default.
- W3047346089 cites W2589023257 @default.
- W3047346089 cites W2599518098 @default.
- W3047346089 cites W2606527202 @default.