FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047360608> ?p ?o ?g. }

• W3047360608 abstract "Abstract Background Angiopoietin-like protein 8 (ANGPTL8), an important regulator of lipid metabolism, is increased in diabetes and is associated with insulin resistance. However, the role of ANGPTL8 in the outcomes of diabetic patients remains unclear. This study aimed to investigate circulating levels of ANGPTL8 in participants with and without diabetes and its potential associations with clinical outcomes in a 5 year cohort study. Methods Propensity-matched cohorts of subjects with and without diabetes from the Risk Evaluation of Cancers in Chinese Diabetic Individuals: A longitudinal (REACTION) study were generated on the basis of age, sex and body mass index at baseline. The primary outcome was all-cause mortality. The secondary outcomes were a composite of new-onset major adverse cardiovascular events, hospitalization for heart failure, and renal dysfunction (eGFR < 60/min/1.73 m 2 ). Results We identified 769 matched pairs of diabetic patients and control subjects. Serum ANGPTL8 levels were elevated in patients with diabetes compared to control subjects (618.82 $$pm$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:mo>±</mml:mo> </mml:math> 318.08 vs 581.20 $$pm$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:mo>±</mml:mo> </mml:math> 299.54 pg/mL, p = 0.03). Binary logistic regression analysis showed that elevated ANGPTL8 levels were associated with greater risk ratios (RRs) of death (RR in quartile 4 vs. quartile 1, 3.54; 95% CI 1.32–9.50) and renal dysfunction (RR in quartile 4 vs. quartile 1, 12.43; 95% CI 1.48–104.81) only in diabetic patients. Multivariable-adjusted restricted cubic spline analyses revealed a significant, linear relationship between ANGPTL8 and all-cause mortality in diabetic patients (p for nonlinear trend = 0.99, p for linear trend = 0.01) but not in control subjects (p for nonlinear trend = 0.26, p for linear trend = 0.80). According to ROC curve analysis, the inclusion of ANGPTL8 in QFrailty score significantly improved its predictive performance for mortality in patients with diabetes. Conclusion Serum ANGPTL8 levels were associated with an increased risk of all-cause mortality and could be used as a potential biomarker for the prediction of death in patients with diabetes." @default.
• W3047360608 created "2020-08-10" @default.
• W3047360608 creator A5001224228 @default.
• W3047360608 creator A5001432063 @default.
• W3047360608 creator A5007067761 @default.
• W3047360608 creator A5011626848 @default.
• W3047360608 creator A5027310979 @default.
• W3047360608 creator A5047301492 @default.
• W3047360608 creator A5063767920 @default.
• W3047360608 creator A5064458021 @default.
• W3047360608 creator A5080121245 @default.
• W3047360608 creator A5081303920 @default.
• W3047360608 date "2020-08-03" @default.
• W3047360608 modified "2023-10-16" @default.
• W3047360608 title "Predictive values of ANGPTL8 on risk of all-cause mortality in diabetic patients: results from the REACTION Study" @default.
• W3047360608 cites W1554335923 @default.
• W3047360608 cites W1705809348 @default.
• W3047360608 cites W1768754709 @default.
• W3047360608 cites W1891874652 @default.
• W3047360608 cites W1983483428 @default.
• W3047360608 cites W1995806275 @default.
• W3047360608 cites W2041664448 @default.
• W3047360608 cites W2048256797 @default.
• W3047360608 cites W2063909341 @default.
• W3047360608 cites W2098082628 @default.
• W3047360608 cites W2098787760 @default.
• W3047360608 cites W2114598208 @default.
• W3047360608 cites W2116873891 @default.
• W3047360608 cites W2127464066 @default.
• W3047360608 cites W2130496000 @default.
• W3047360608 cites W2141915302 @default.
• W3047360608 cites W2145277190 @default.
• W3047360608 cites W2160234571 @default.
• W3047360608 cites W2203915403 @default.
• W3047360608 cites W2225025771 @default.
• W3047360608 cites W2289823333 @default.
• W3047360608 cites W2317521667 @default.
• W3047360608 cites W2338167986 @default.
• W3047360608 cites W2482817411 @default.
• W3047360608 cites W2515945444 @default.
• W3047360608 cites W2531285001 @default.
• W3047360608 cites W2550838972 @default.
• W3047360608 cites W2580216878 @default.
• W3047360608 cites W2594471709 @default.
• W3047360608 cites W2606804985 @default.
• W3047360608 cites W2730976293 @default.
• W3047360608 cites W2736242957 @default.
• W3047360608 cites W2755651830 @default.
• W3047360608 cites W2776548205 @default.
• W3047360608 cites W2795228071 @default.
• W3047360608 cites W2803581246 @default.
• W3047360608 cites W2806808815 @default.
• W3047360608 cites W2809888393 @default.
• W3047360608 cites W2809926833 @default.
• W3047360608 cites W2810733534 @default.
• W3047360608 cites W2831010787 @default.
• W3047360608 cites W2893919811 @default.
• W3047360608 cites W2894528168 @default.
• W3047360608 cites W2899649682 @default.
• W3047360608 cites W2900413769 @default.
• W3047360608 cites W2914362161 @default.
• W3047360608 cites W2924575318 @default.
• W3047360608 cites W2947184815 @default.
• W3047360608 cites W2947951543 @default.
• W3047360608 cites W2987344867 @default.
• W3047360608 cites W2995472624 @default.
• W3047360608 doi "https://doi.org/10.1186/s12933-020-01103-7" @default.
• W3047360608 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7398345" @default.
• W3047360608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32746907" @default.
• W3047360608 hasPublicationYear "2020" @default.
• W3047360608 type Work @default.
• W3047360608 sameAs 3047360608 @default.
• W3047360608 citedByCount "8" @default.
• W3047360608 countsByYear W30473606082021 @default.
• W3047360608 countsByYear W30473606082022 @default.
• W3047360608 countsByYear W30473606082023 @default.
• W3047360608 crossrefType "journal-article" @default.
• W3047360608 hasAuthorship W3047360608A5001224228 @default.
• W3047360608 hasAuthorship W3047360608A5001432063 @default.
• W3047360608 hasAuthorship W3047360608A5007067761 @default.
• W3047360608 hasAuthorship W3047360608A5011626848 @default.
• W3047360608 hasAuthorship W3047360608A5027310979 @default.
• W3047360608 hasAuthorship W3047360608A5047301492 @default.
• W3047360608 hasAuthorship W3047360608A5063767920 @default.
• W3047360608 hasAuthorship W3047360608A5064458021 @default.
• W3047360608 hasAuthorship W3047360608A5080121245 @default.
• W3047360608 hasAuthorship W3047360608A5081303920 @default.
• W3047360608 hasBestOaLocation W30473606081 @default.
• W3047360608 hasConcept C126322002 @default.
• W3047360608 hasConcept C134018914 @default.
• W3047360608 hasConcept C151956035 @default.
• W3047360608 hasConcept C159641895 @default.
• W3047360608 hasConcept C2777391703 @default.
• W3047360608 hasConcept C2780221984 @default.
• W3047360608 hasConcept C44249647 @default.
• W3047360608 hasConcept C50382708 @default.
• W3047360608 hasConcept C555293320 @default.
• W3047360608 hasConcept C68443243 @default.
• W3047360608 hasConcept C71924100 @default.
• W3047360608 hasConcept C72563966 @default.

• next