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- W3047370735 abstract "Oxidative stress is a determining factor in the pathophysiology of heart disease. This study aimed at evaluating the protective activity of Abengourou Forastero cocoa in doxorubicin-induced cardiotoxicity in rats. Thirty (30) wistar rats divided into 5 groups were orally pretreated with distilled water, resveratrol (25 mg/kg/day) or defatted Abengourou Forastero cocoa powder (1000 and 1500 mg/kg/day) for sixty (60) consecutive days. A single dose of doxorubicin (15 mg/kg/day) was administered on day 59 by intraperitoneal route. The biochemical parameters were assessed and a histological examination of the heart was performed. This study showed that doxorubicin treated animals exhibited a significant increase of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, phosphocreatine kinases, creatine kinases, total cholesterol, triglycerides, and LDL-cholesterol levels in serum. However, a decrease of HDL-cholesterol and an alteration of cardiac tissue were noticed. Preventive treatment with Abengourou Forastero cocoa at doses of 1000 and 1500 mg/kg significantly reduced the biochemical and histological alterations induced by doxorubicin. Results showed that Abengourou Forastero cocoa protects and prevents against doxorubicin-induced cardiac damage." @default.
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- W3047370735 date "2020-07-21" @default.
- W3047370735 modified "2023-09-26" @default.
- W3047370735 title "Effect of Abengourou forastero cocoa against doxorubicin-induced cardiotoxicity in experimental rats" @default.
- W3047370735 doi "https://doi.org/10.5138/09750185.2392" @default.
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