Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047376062> ?p ?o ?g. }
- W3047376062 endingPage "20087" @default.
- W3047376062 startingPage "20077" @default.
- W3047376062 abstract "Significance The global health burden could be substantially alleviated by the creation of universal vaccines against highly mutable pathogens like HIV and influenza. Broadly neutralizing antibodies (bnAbs) are encouraging targets for such vaccines, because they can bind to diverse strains of these pathogens. BnAbs typically develop only after the immune system has been exposed to many mutated versions of a pathogen, and then too in few people and low numbers. Thus, sequentially administering multiple different pathogen-like proteins is a promising strategy to elicit bnAbs through vaccination. However, it remains unclear how best to design/administer these proteins. We explore this using physics-based simulations and provide mechanistic insights into antibody evolution that could guide creation of universal vaccines against highly mutable pathogens." @default.
- W3047376062 created "2020-08-10" @default.
- W3047376062 creator A5004378407 @default.
- W3047376062 creator A5019777093 @default.
- W3047376062 creator A5051299919 @default.
- W3047376062 creator A5061654582 @default.
- W3047376062 date "2020-08-03" @default.
- W3047376062 modified "2023-10-02" @default.
- W3047376062 title "Optimizing immunization protocols to elicit broadly neutralizing antibodies" @default.
- W3047376062 cites W1508120038 @default.
- W3047376062 cites W1534852475 @default.
- W3047376062 cites W1919561613 @default.
- W3047376062 cites W1954069242 @default.
- W3047376062 cites W1978398372 @default.
- W3047376062 cites W1979058462 @default.
- W3047376062 cites W1981197474 @default.
- W3047376062 cites W1984179187 @default.
- W3047376062 cites W1989134497 @default.
- W3047376062 cites W2001775594 @default.
- W3047376062 cites W2010959676 @default.
- W3047376062 cites W2016054852 @default.
- W3047376062 cites W2037320559 @default.
- W3047376062 cites W2052937459 @default.
- W3047376062 cites W2054069391 @default.
- W3047376062 cites W2068747743 @default.
- W3047376062 cites W2069784383 @default.
- W3047376062 cites W2071380288 @default.
- W3047376062 cites W2093626188 @default.
- W3047376062 cites W2102253058 @default.
- W3047376062 cites W2113236498 @default.
- W3047376062 cites W2118274231 @default.
- W3047376062 cites W2120653364 @default.
- W3047376062 cites W2129138941 @default.
- W3047376062 cites W2133233128 @default.
- W3047376062 cites W2134803208 @default.
- W3047376062 cites W2136225973 @default.
- W3047376062 cites W2140498738 @default.
- W3047376062 cites W2157807259 @default.
- W3047376062 cites W2171176459 @default.
- W3047376062 cites W2181008927 @default.
- W3047376062 cites W2206418905 @default.
- W3047376062 cites W2234728088 @default.
- W3047376062 cites W2277351499 @default.
- W3047376062 cites W2281246504 @default.
- W3047376062 cites W2289942604 @default.
- W3047376062 cites W2302583067 @default.
- W3047376062 cites W2336507460 @default.
- W3047376062 cites W2381153372 @default.
- W3047376062 cites W2406803260 @default.
- W3047376062 cites W2515557558 @default.
- W3047376062 cites W2515956381 @default.
- W3047376062 cites W2518999491 @default.
- W3047376062 cites W2520562417 @default.
- W3047376062 cites W2521741241 @default.
- W3047376062 cites W2527863850 @default.
- W3047376062 cites W2536780048 @default.
- W3047376062 cites W2581400213 @default.
- W3047376062 cites W2588930849 @default.
- W3047376062 cites W2590848450 @default.
- W3047376062 cites W2595849159 @default.
- W3047376062 cites W2616862289 @default.
- W3047376062 cites W2682456409 @default.
- W3047376062 cites W2683294477 @default.
- W3047376062 cites W2777807953 @default.
- W3047376062 cites W2780290167 @default.
- W3047376062 cites W2787724043 @default.
- W3047376062 cites W2790689931 @default.
- W3047376062 cites W2791741332 @default.
- W3047376062 cites W2793636839 @default.
- W3047376062 cites W2803694530 @default.
- W3047376062 cites W2804906219 @default.
- W3047376062 cites W2805330890 @default.
- W3047376062 cites W2805857350 @default.
- W3047376062 cites W2806827139 @default.
- W3047376062 cites W2889633239 @default.
- W3047376062 cites W2892422982 @default.
- W3047376062 cites W2955123934 @default.
- W3047376062 cites W2963367348 @default.
- W3047376062 cites W2995806710 @default.
- W3047376062 cites W4230654908 @default.
- W3047376062 cites W4246504300 @default.
- W3047376062 doi "https://doi.org/10.1073/pnas.1919329117" @default.
- W3047376062 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7443869" @default.
- W3047376062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32747563" @default.
- W3047376062 hasPublicationYear "2020" @default.
- W3047376062 type Work @default.
- W3047376062 sameAs 3047376062 @default.
- W3047376062 citedByCount "30" @default.
- W3047376062 countsByYear W30473760622019 @default.
- W3047376062 countsByYear W30473760622020 @default.
- W3047376062 countsByYear W30473760622021 @default.
- W3047376062 countsByYear W30473760622022 @default.
- W3047376062 countsByYear W30473760622023 @default.
- W3047376062 crossrefType "journal-article" @default.
- W3047376062 hasAuthorship W3047376062A5004378407 @default.
- W3047376062 hasAuthorship W3047376062A5019777093 @default.
- W3047376062 hasAuthorship W3047376062A5051299919 @default.
- W3047376062 hasAuthorship W3047376062A5061654582 @default.