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- W3047380247 abstract "Cystine/glutamic acid reverse transporter (System Xc−), a member of the amino acid transporter family, consists of two subunits, light chain xCT and heavy chain 4F2hc. xCT is the cystine/glutamate antiporter solute carrier family 7 member 11 (SLC7A11), which promotes cystine uptake and glutathione biosynthetic, thus protecting against oxidative stress and ferroptosis. Studies have confirmed that xCT is highly expressed in a variety of tumour and is associated with tumour proliferation, invasion, metastasis, drug resistance and ferroptosis, and can be used as a potential target for tumour treatment. This review provides insights into the biological effects of xCT and contribute to the development of new xCT-based strategies." @default.
- W3047380247 created "2020-08-10" @default.
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- W3047380247 date "2020-08-04" @default.
- W3047380247 modified "2023-10-18" @default.
- W3047380247 title "Cystine‐glutamate antiporter <scp>xCT</scp> as a therapeutic target for cancer" @default.
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- W3047380247 doi "https://doi.org/10.1002/cbf.3581" @default.
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