FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047412242> ?p ?o ?g. }

• W3047412242 abstract "ABSTRACT The nuclear export receptor CRM1 (XPO1) recognizes and binds specific sequence motifs termed nuclear export signals (NESs) in cargo proteins. About 200 NES motifs have been identified, but over a thousand human proteins are potential CRM1 cargos, and most of their NESs remain to be identified. On the other hand, the interaction of NES peptides with the “NES-binding groove” of CRM1 has been studied in detail using structural and biochemical analyses, but a better understanding of CRM1 function requires further investigation of how the results from these in vitro studies translate into actual NES export in a cellular context. Here we show that a simple cellular assay, based on a recently described reporter (SRV B/A ), can be applied to identify novel potential NESs motifs, and to obtain relevant information on different aspects of CRM1-mediated NES export. Using cellular assays, we first map 19 new sequence motifs with nuclear export activity in 14 cancer-related proteins that are potential CRM1 cargos. Next, we investigate the effect of mutations in individual NES-binding groove residues, providing further insight into CRM1-mediated NES export. Finally, we extend the search for CRM1-dependent NESs to a recently uncovered, but potentially vast, set of small proteins called micropeptides. By doing so, we report the first NES-harbouring human micropeptides." @default.
• W3047412242 created "2020-08-10" @default.
• W3047412242 creator A5022006722 @default.
• W3047412242 creator A5068853975 @default.
• W3047412242 creator A5069256506 @default.
• W3047412242 creator A5074495063 @default.
• W3047412242 date "2020-08-04" @default.
• W3047412242 modified "2023-09-23" @default.
• W3047412242 title "Using a simple cellular assay to map NES motifs in cancer-related proteins, gain insight into CRM1-mediated NES export, and search for NES-harbouring micropeptides" @default.
• W3047412242 cites W1565506774 @default.
• W3047412242 cites W1971708920 @default.
• W3047412242 cites W1971961101 @default.
• W3047412242 cites W1977558343 @default.
• W3047412242 cites W1978417963 @default.
• W3047412242 cites W1987019783 @default.
• W3047412242 cites W1990105977 @default.
• W3047412242 cites W1993355130 @default.
• W3047412242 cites W2002245757 @default.
• W3047412242 cites W2006971960 @default.
• W3047412242 cites W2017307629 @default.
• W3047412242 cites W2021789806 @default.
• W3047412242 cites W2023079546 @default.
• W3047412242 cites W2028930390 @default.
• W3047412242 cites W2034577054 @default.
• W3047412242 cites W2044568075 @default.
• W3047412242 cites W2066239225 @default.
• W3047412242 cites W2073109412 @default.
• W3047412242 cites W2079021353 @default.
• W3047412242 cites W2091364041 @default.
• W3047412242 cites W2095063181 @default.
• W3047412242 cites W2104580729 @default.
• W3047412242 cites W2105544978 @default.
• W3047412242 cites W2119483030 @default.
• W3047412242 cites W2120956575 @default.
• W3047412242 cites W2124886189 @default.
• W3047412242 cites W2153988632 @default.
• W3047412242 cites W2159860065 @default.
• W3047412242 cites W2163833112 @default.
• W3047412242 cites W2167279371 @default.
• W3047412242 cites W2181261574 @default.
• W3047412242 cites W2218364825 @default.
• W3047412242 cites W2257582870 @default.
• W3047412242 cites W2434989319 @default.
• W3047412242 cites W2474334476 @default.
• W3047412242 cites W2582554428 @default.
• W3047412242 cites W2593128211 @default.
• W3047412242 cites W2761249484 @default.
• W3047412242 cites W2801240764 @default.
• W3047412242 cites W2809240511 @default.
• W3047412242 cites W2890442448 @default.
• W3047412242 cites W2898900975 @default.
• W3047412242 cites W2962640793 @default.
• W3047412242 cites W2966984447 @default.
• W3047412242 cites W2998998400 @default.
• W3047412242 doi "https://doi.org/10.1101/2020.08.04.234948" @default.
• W3047412242 hasPublicationYear "2020" @default.
• W3047412242 type Work @default.
• W3047412242 sameAs 3047412242 @default.
• W3047412242 citedByCount "1" @default.
• W3047412242 countsByYear W30474122422023 @default.
• W3047412242 crossrefType "posted-content" @default.
• W3047412242 hasAuthorship W3047412242A5022006722 @default.
• W3047412242 hasAuthorship W3047412242A5068853975 @default.
• W3047412242 hasAuthorship W3047412242A5069256506 @default.
• W3047412242 hasAuthorship W3047412242A5074495063 @default.
• W3047412242 hasBestOaLocation W30474122421 @default.
• W3047412242 hasConcept C104317684 @default.
• W3047412242 hasConcept C14036430 @default.
• W3047412242 hasConcept C151730666 @default.
• W3047412242 hasConcept C2779343474 @default.
• W3047412242 hasConcept C2780114586 @default.
• W3047412242 hasConcept C54355233 @default.
• W3047412242 hasConcept C54757728 @default.
• W3047412242 hasConcept C70721500 @default.
• W3047412242 hasConcept C86803240 @default.
• W3047412242 hasConceptScore W3047412242C104317684 @default.
• W3047412242 hasConceptScore W3047412242C14036430 @default.
• W3047412242 hasConceptScore W3047412242C151730666 @default.
• W3047412242 hasConceptScore W3047412242C2779343474 @default.
• W3047412242 hasConceptScore W3047412242C2780114586 @default.
• W3047412242 hasConceptScore W3047412242C54355233 @default.
• W3047412242 hasConceptScore W3047412242C54757728 @default.
• W3047412242 hasConceptScore W3047412242C70721500 @default.
• W3047412242 hasConceptScore W3047412242C86803240 @default.
• W3047412242 hasLocation W30474122421 @default.
• W3047412242 hasLocation W30474122422 @default.
• W3047412242 hasOpenAccess W3047412242 @default.
• W3047412242 hasPrimaryLocation W30474122421 @default.
• W3047412242 hasRelatedWork W14373237 @default.
• W3047412242 hasRelatedWork W1442632 @default.
• W3047412242 hasRelatedWork W16713247 @default.
• W3047412242 hasRelatedWork W20182053 @default.
• W3047412242 hasRelatedWork W27531659 @default.
• W3047412242 hasRelatedWork W32298901 @default.
• W3047412242 hasRelatedWork W5168557 @default.
• W3047412242 hasRelatedWork W8231427 @default.
• W3047412242 hasRelatedWork W8288889 @default.
• W3047412242 hasRelatedWork W16826791 @default.
• W3047412242 isParatext "false" @default.
• W3047412242 isRetracted "false" @default.

• next