FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047457019> ?p ?o ?g. }

• W3047457019 endingPage "107986" @default.
• W3047457019 startingPage "107986" @default.
• W3047457019 abstract "Isotope-based assessment of metabolic flux is achieved through a judicious balance of measurements and assumptions. Recent publications debate the validity of key assumptions used to model stable isotope labeling of liver metabolism in vivo. Here, we examine the controversy surrounding estimates of liver citric acid cycle and gluconeogenesis fluxes using a flexible modeling platform that enables rigorous testing of standard assumptions. Fasted C57BL/6J mice are infused with [13C3]lactate or [13C3]propionate isotopes, and hepatic fluxes are regressed using models with gradually increasing complexity and relaxed assumptions. We confirm that liver pyruvate cycling fluxes are incongruent between different 13C tracers in models with conventional assumptions. When models are expanded to include more labeling measurements and fewer constraining assumptions, however, liver pyruvate cycling is significant, and inconsistencies in hepatic flux estimates using [13C3]lactate and [13C3]propionate isotopes emanate, in part, from peripheral tracer recycling and incomplete isotope equilibration within the citric acid cycle." @default.
• W3047457019 created "2020-08-10" @default.
• W3047457019 creator A5003305213 @default.
• W3047457019 creator A5025289763 @default.
• W3047457019 creator A5044985316 @default.
• W3047457019 date "2020-08-01" @default.
• W3047457019 modified "2023-10-12" @default.
• W3047457019 title "In Vivo Estimates of Liver Metabolic Flux Assessed by 13C-Propionate and 13C-Lactate Are Impacted by Tracer Recycling and Equilibrium Assumptions" @default.
• W3047457019 cites W122120889 @default.
• W3047457019 cites W1483934588 @default.
• W3047457019 cites W1490420782 @default.
• W3047457019 cites W1542238138 @default.
• W3047457019 cites W1572846506 @default.
• W3047457019 cites W1985236262 @default.
• W3047457019 cites W2009974450 @default.
• W3047457019 cites W2024930946 @default.
• W3047457019 cites W2031533316 @default.
• W3047457019 cites W2033471108 @default.
• W3047457019 cites W2034674277 @default.
• W3047457019 cites W2036097574 @default.
• W3047457019 cites W2049759143 @default.
• W3047457019 cites W2059793508 @default.
• W3047457019 cites W2069764796 @default.
• W3047457019 cites W2081936147 @default.
• W3047457019 cites W2082157022 @default.
• W3047457019 cites W2083807792 @default.
• W3047457019 cites W2092493462 @default.
• W3047457019 cites W2134138595 @default.
• W3047457019 cites W2136505278 @default.
• W3047457019 cites W2139397177 @default.
• W3047457019 cites W2146095405 @default.
• W3047457019 cites W2153302582 @default.
• W3047457019 cites W2171655969 @default.
• W3047457019 cites W2175091172 @default.
• W3047457019 cites W2226205752 @default.
• W3047457019 cites W2304237298 @default.
• W3047457019 cites W2309835329 @default.
• W3047457019 cites W2412169590 @default.
• W3047457019 cites W2464846577 @default.
• W3047457019 cites W2763979809 @default.
• W3047457019 cites W2765303057 @default.
• W3047457019 cites W2939175683 @default.
• W3047457019 cites W2985193984 @default.
• W3047457019 cites W2996888210 @default.
• W3047457019 cites W3008309410 @default.
• W3047457019 doi "https://doi.org/10.1016/j.celrep.2020.107986" @default.
• W3047457019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7451222" @default.
• W3047457019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32755580" @default.
• W3047457019 hasPublicationYear "2020" @default.
• W3047457019 type Work @default.
• W3047457019 sameAs 3047457019 @default.
• W3047457019 citedByCount "25" @default.
• W3047457019 countsByYear W30474570192020 @default.
• W3047457019 countsByYear W30474570192021 @default.
• W3047457019 countsByYear W30474570192022 @default.
• W3047457019 countsByYear W30474570192023 @default.
• W3047457019 crossrefType "journal-article" @default.
• W3047457019 hasAuthorship W3047457019A5003305213 @default.
• W3047457019 hasAuthorship W3047457019A5025289763 @default.
• W3047457019 hasAuthorship W3047457019A5044985316 @default.
• W3047457019 hasBestOaLocation W30474570191 @default.
• W3047457019 hasConcept C121332964 @default.
• W3047457019 hasConcept C127124265 @default.
• W3047457019 hasConcept C150903083 @default.
• W3047457019 hasConcept C164304813 @default.
• W3047457019 hasConcept C165135838 @default.
• W3047457019 hasConcept C178790620 @default.
• W3047457019 hasConcept C185544564 @default.
• W3047457019 hasConcept C185592680 @default.
• W3047457019 hasConcept C207001950 @default.
• W3047457019 hasConcept C20904676 @default.
• W3047457019 hasConcept C22117777 @default.
• W3047457019 hasConcept C2778863792 @default.
• W3047457019 hasConcept C2780014933 @default.
• W3047457019 hasConcept C32909587 @default.
• W3047457019 hasConcept C39432304 @default.
• W3047457019 hasConcept C55493867 @default.
• W3047457019 hasConcept C62231903 @default.
• W3047457019 hasConcept C68709404 @default.
• W3047457019 hasConcept C86803240 @default.
• W3047457019 hasConceptScore W3047457019C121332964 @default.
• W3047457019 hasConceptScore W3047457019C127124265 @default.
• W3047457019 hasConceptScore W3047457019C150903083 @default.
• W3047457019 hasConceptScore W3047457019C164304813 @default.
• W3047457019 hasConceptScore W3047457019C165135838 @default.
• W3047457019 hasConceptScore W3047457019C178790620 @default.
• W3047457019 hasConceptScore W3047457019C185544564 @default.
• W3047457019 hasConceptScore W3047457019C185592680 @default.
• W3047457019 hasConceptScore W3047457019C207001950 @default.
• W3047457019 hasConceptScore W3047457019C20904676 @default.
• W3047457019 hasConceptScore W3047457019C22117777 @default.
• W3047457019 hasConceptScore W3047457019C2778863792 @default.
• W3047457019 hasConceptScore W3047457019C2780014933 @default.
• W3047457019 hasConceptScore W3047457019C32909587 @default.
• W3047457019 hasConceptScore W3047457019C39432304 @default.
• W3047457019 hasConceptScore W3047457019C55493867 @default.
• W3047457019 hasConceptScore W3047457019C62231903 @default.
• W3047457019 hasConceptScore W3047457019C68709404 @default.

• next