FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047468300> ?p ?o ?g. }

• W3047468300 endingPage "450" @default.
• W3047468300 startingPage "444" @default.
• W3047468300 abstract "Abstract A highly sensitive and specific liquid chromatography‐elctrospray ionization tandem mass spectrometry method was developed and validated for rapid determination of risperidone and its active metabolite in rat dried blood spots and dried plasma spots. Chromatographic separation was achieved through ZIC®‐HILIC (250 × 4.6 mm, 5 µm) at 25°C using 10 mM ammonium acetate (pH: 3.0, adjusted with acetic acid) and acetonitrile (12:88, v/v) as a mobile phase. Tandem mass spectrometry detection was performed in positive ion electrospray ionization using multiple reaction monitoring mode to monitor precursor → product ion transitions m/z 411.2→191.1 for Risperidone, m/z 427.2→207.1 for its metabolite (Risperidone‐9‐OH), respectively. The lower limit of quantification of Risperidone and Risperidone‐9‐OH were 0.95 and 0.90 ng/mL in rat dried blood spots, respectively. The developed bioassay method was successfully applied to study the pharmacokinetic profile of Risperidone and Risperidone‐9‐OH using Iloperidone as an internal standard. As per pharmacokinetic studies, C max of Risperidone and Risperidone‐9‐OH in dried blood spots was 36.2 and 28.9 ng/mL; and in dried plasma spots was 38.2 and 30.2 ng/mL, respectively. Similarly, t max of Risperidone and Risperidone‐9‐OH in dried blood spots was 1.4 and 14.7 h; and in dried plasma spots was 1.54 and 15.4 h, respectively." @default.
• W3047468300 created "2020-08-10" @default.
• W3047468300 creator A5020736702 @default.
• W3047468300 creator A5042033324 @default.
• W3047468300 creator A5075889266 @default.
• W3047468300 creator A5080689137 @default.
• W3047468300 date "2020-08-02" @default.
• W3047468300 modified "2023-09-26" @default.
• W3047468300 title "Bioassay studies of Risperidone and its active metabolite in rat dried blood spots and dried plasma spots using LC‐ESI‐MS/MS: Comparison of their pharmacokinetic profiles" @default.
• W3047468300 cites W1966260106 @default.
• W3047468300 cites W1991006569 @default.
• W3047468300 cites W1998564944 @default.
• W3047468300 cites W2008283765 @default.
• W3047468300 cites W2010365552 @default.
• W3047468300 cites W2019570577 @default.
• W3047468300 cites W2043599002 @default.
• W3047468300 cites W2049079000 @default.
• W3047468300 cites W2049897421 @default.
• W3047468300 cites W2052003580 @default.
• W3047468300 cites W2060763377 @default.
• W3047468300 cites W2064222635 @default.
• W3047468300 cites W2067436360 @default.
• W3047468300 cites W2068688546 @default.
• W3047468300 cites W2072957416 @default.
• W3047468300 cites W2083033607 @default.
• W3047468300 cites W2090981029 @default.
• W3047468300 cites W2102035792 @default.
• W3047468300 cites W2102936147 @default.
• W3047468300 cites W2121017162 @default.
• W3047468300 cites W2161641226 @default.
• W3047468300 cites W22559864 @default.
• W3047468300 cites W2883964207 @default.
• W3047468300 doi "https://doi.org/10.1002/sscp.202000021" @default.
• W3047468300 hasPublicationYear "2020" @default.
• W3047468300 type Work @default.
• W3047468300 sameAs 3047468300 @default.
• W3047468300 citedByCount "0" @default.
• W3047468300 crossrefType "journal-article" @default.
• W3047468300 hasAuthorship W3047468300A5020736702 @default.
• W3047468300 hasAuthorship W3047468300A5042033324 @default.
• W3047468300 hasAuthorship W3047468300A5075889266 @default.
• W3047468300 hasAuthorship W3047468300A5080689137 @default.
• W3047468300 hasConcept C112705442 @default.
• W3047468300 hasConcept C147789679 @default.
• W3047468300 hasConcept C149151106 @default.
• W3047468300 hasConcept C162356407 @default.
• W3047468300 hasConcept C185592680 @default.
• W3047468300 hasConcept C199360897 @default.
• W3047468300 hasConcept C2776412080 @default.
• W3047468300 hasConcept C2776597655 @default.
• W3047468300 hasConcept C2777477808 @default.
• W3047468300 hasConcept C2780057945 @default.
• W3047468300 hasConcept C2781255879 @default.
• W3047468300 hasConcept C3017516299 @default.
• W3047468300 hasConcept C31827203 @default.
• W3047468300 hasConcept C40684141 @default.
• W3047468300 hasConcept C41008148 @default.
• W3047468300 hasConcept C43617362 @default.
• W3047468300 hasConcept C55493867 @default.
• W3047468300 hasConcept C71043704 @default.
• W3047468300 hasConcept C71924100 @default.
• W3047468300 hasConcept C98274493 @default.
• W3047468300 hasConceptScore W3047468300C112705442 @default.
• W3047468300 hasConceptScore W3047468300C147789679 @default.
• W3047468300 hasConceptScore W3047468300C149151106 @default.
• W3047468300 hasConceptScore W3047468300C162356407 @default.
• W3047468300 hasConceptScore W3047468300C185592680 @default.
• W3047468300 hasConceptScore W3047468300C199360897 @default.
• W3047468300 hasConceptScore W3047468300C2776412080 @default.
• W3047468300 hasConceptScore W3047468300C2776597655 @default.
• W3047468300 hasConceptScore W3047468300C2777477808 @default.
• W3047468300 hasConceptScore W3047468300C2780057945 @default.
• W3047468300 hasConceptScore W3047468300C2781255879 @default.
• W3047468300 hasConceptScore W3047468300C3017516299 @default.
• W3047468300 hasConceptScore W3047468300C31827203 @default.
• W3047468300 hasConceptScore W3047468300C40684141 @default.
• W3047468300 hasConceptScore W3047468300C41008148 @default.
• W3047468300 hasConceptScore W3047468300C43617362 @default.
• W3047468300 hasConceptScore W3047468300C55493867 @default.
• W3047468300 hasConceptScore W3047468300C71043704 @default.
• W3047468300 hasConceptScore W3047468300C71924100 @default.
• W3047468300 hasConceptScore W3047468300C98274493 @default.
• W3047468300 hasIssue "10" @default.
• W3047468300 hasLocation W30474683001 @default.
• W3047468300 hasOpenAccess W3047468300 @default.
• W3047468300 hasPrimaryLocation W30474683001 @default.
• W3047468300 hasRelatedWork W1903815649 @default.
• W3047468300 hasRelatedWork W1999548340 @default.
• W3047468300 hasRelatedWork W2003757031 @default.
• W3047468300 hasRelatedWork W2014605936 @default.
• W3047468300 hasRelatedWork W2060116490 @default.
• W3047468300 hasRelatedWork W2074212848 @default.
• W3047468300 hasRelatedWork W2079130042 @default.
• W3047468300 hasRelatedWork W2341315574 @default.
• W3047468300 hasRelatedWork W3047468300 @default.
• W3047468300 hasRelatedWork W893887697 @default.
• W3047468300 hasVolume "3" @default.
• W3047468300 isParatext "false" @default.

• next