FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047494037> ?p ?o ?g. }

• W3047494037 endingPage "2976" @default.
• W3047494037 startingPage "2970" @default.
• W3047494037 abstract "Ischemic renal failure is an inflammatory disease that can affect various organs, including the heart. The organ responds to the stimulus and undergoes tissue remodeling that can result in cardiac hypertrophy. This study aimed to characterize the cardiac global gene expression profile in renal ischemia/reperfusion (IR) model using microarray technology. To do that, left kidney ischemia was induced in male C57BL/6 mice for 60 minutes, followed by reperfusion (IR) for 5, 8, 15, or 20 days post ischemia (dpi). Total cardiac tissue RNA was extracted and hybridized to chips with 35,000 mouse genes. The GeneChip Mouse Genome 430 2.0 Array Expression chip (Affymetrix) was used, and CEL files generated were processed with DNA-Chip-Analyzer (dCHIP) software. Subsequent analysis considered only differences among groups of at least 1.2-fold (up or down) expression changes. Analyses of the samples indicated positive modulation of 17,413 genes and 405 pathways and negative modulation of 18,287 genes and 300 pathways. A narrower analysis of genes related to inflammation, metabolism, apoptosis, oxidative stress, and channels/ion transport was performance, and it was correlated with IR injury, corroborating previous data from literature. Renal IR induced a global shift in cardiac tissue gene expression; in particular, genes related to the inflammatory system and cardiomyocyte function were changed. The in-depth study of the cell signaling in the present study could stimulate the development of new therapeutic option to ameliorate the outcome of renal-IR-induced heart damage. • Ischemic renal failure is an inflammatory disease that can affect the heart, which responds to tissue remodeling that can result in cardiac hypertrophy. • The cardiac global gene expression profile in renal ischemia/reperfusion model using microarray technology was analyzed. • Analyses of the samples indicated positive modulation of 17,413 genes and 405 pathways and negative modulation of 18,287 genes and 300 pathways, which were mainly related to inflammation, metabolism, apoptosis, oxidative stress, and channels/ion transport." @default.
• W3047494037 created "2020-08-10" @default.
• W3047494037 creator A5001981967 @default.
• W3047494037 creator A5002153983 @default.
• W3047494037 creator A5029056539 @default.
• W3047494037 creator A5033768252 @default.
• W3047494037 creator A5049131306 @default.
• W3047494037 creator A5057556859 @default.
• W3047494037 creator A5062490039 @default.
• W3047494037 creator A5085317996 @default.
• W3047494037 date "2020-12-01" @default.
• W3047494037 modified "2023-10-11" @default.
• W3047494037 title "Time Course of Gene Expression Profile in Renal Ischemia and Reperfusion Injury in Mice" @default.
• W3047494037 cites W1594655861 @default.
• W3047494037 cites W1956440423 @default.
• W3047494037 cites W1971140824 @default.
• W3047494037 cites W1974429316 @default.
• W3047494037 cites W1999062564 @default.
• W3047494037 cites W2021132199 @default.
• W3047494037 cites W2073352428 @default.
• W3047494037 cites W2091592969 @default.
• W3047494037 cites W2101891512 @default.
• W3047494037 cites W2102421606 @default.
• W3047494037 cites W2104241530 @default.
• W3047494037 cites W2106323366 @default.
• W3047494037 cites W2131989143 @default.
• W3047494037 cites W2132622900 @default.
• W3047494037 cites W2140096729 @default.
• W3047494037 cites W2177776720 @default.
• W3047494037 cites W2178086146 @default.
• W3047494037 cites W2180399398 @default.
• W3047494037 cites W2194837889 @default.
• W3047494037 cites W2197177073 @default.
• W3047494037 cites W2255639533 @default.
• W3047494037 cites W2575523144 @default.
• W3047494037 cites W2619702215 @default.
• W3047494037 cites W2735815044 @default.
• W3047494037 cites W2940997004 @default.
• W3047494037 cites W2957917146 @default.
• W3047494037 cites W2966947080 @default.
• W3047494037 cites W2974323531 @default.
• W3047494037 cites W2982373771 @default.
• W3047494037 cites W7419881 @default.
• W3047494037 doi "https://doi.org/10.1016/j.transproceed.2020.06.029" @default.
• W3047494037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32763007" @default.
• W3047494037 hasPublicationYear "2020" @default.
• W3047494037 type Work @default.
• W3047494037 sameAs 3047494037 @default.
• W3047494037 citedByCount "2" @default.
• W3047494037 countsByYear W30474940372022 @default.
• W3047494037 crossrefType "journal-article" @default.
• W3047494037 hasAuthorship W3047494037A5001981967 @default.
• W3047494037 hasAuthorship W3047494037A5002153983 @default.
• W3047494037 hasAuthorship W3047494037A5029056539 @default.
• W3047494037 hasAuthorship W3047494037A5033768252 @default.
• W3047494037 hasAuthorship W3047494037A5049131306 @default.
• W3047494037 hasAuthorship W3047494037A5057556859 @default.
• W3047494037 hasAuthorship W3047494037A5062490039 @default.
• W3047494037 hasAuthorship W3047494037A5085317996 @default.
• W3047494037 hasConcept C104317684 @default.
• W3047494037 hasConcept C126322002 @default.
• W3047494037 hasConcept C134018914 @default.
• W3047494037 hasConcept C142724271 @default.
• W3047494037 hasConcept C150194340 @default.
• W3047494037 hasConcept C186836561 @default.
• W3047494037 hasConcept C203014093 @default.
• W3047494037 hasConcept C24361400 @default.
• W3047494037 hasConcept C2776914184 @default.
• W3047494037 hasConcept C2778653478 @default.
• W3047494037 hasConcept C2780091579 @default.
• W3047494037 hasConcept C2780114680 @default.
• W3047494037 hasConcept C2780721119 @default.
• W3047494037 hasConcept C541997718 @default.
• W3047494037 hasConcept C54355233 @default.
• W3047494037 hasConcept C71924100 @default.
• W3047494037 hasConcept C8415881 @default.
• W3047494037 hasConcept C86803240 @default.
• W3047494037 hasConceptScore W3047494037C104317684 @default.
• W3047494037 hasConceptScore W3047494037C126322002 @default.
• W3047494037 hasConceptScore W3047494037C134018914 @default.
• W3047494037 hasConceptScore W3047494037C142724271 @default.
• W3047494037 hasConceptScore W3047494037C150194340 @default.
• W3047494037 hasConceptScore W3047494037C186836561 @default.
• W3047494037 hasConceptScore W3047494037C203014093 @default.
• W3047494037 hasConceptScore W3047494037C24361400 @default.
• W3047494037 hasConceptScore W3047494037C2776914184 @default.
• W3047494037 hasConceptScore W3047494037C2778653478 @default.
• W3047494037 hasConceptScore W3047494037C2780091579 @default.
• W3047494037 hasConceptScore W3047494037C2780114680 @default.
• W3047494037 hasConceptScore W3047494037C2780721119 @default.
• W3047494037 hasConceptScore W3047494037C541997718 @default.
• W3047494037 hasConceptScore W3047494037C54355233 @default.
• W3047494037 hasConceptScore W3047494037C71924100 @default.
• W3047494037 hasConceptScore W3047494037C8415881 @default.
• W3047494037 hasConceptScore W3047494037C86803240 @default.
• W3047494037 hasFunder F4320308812 @default.
• W3047494037 hasIssue "10" @default.
• W3047494037 hasLocation W30474940371 @default.

• next