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- W3047564846 abstract "Objective: to identify among the allelic polymorphisms of the folate cycle genes: RFC-1 80G> A, MTHFR C677T and A1298C, TS2R/3R and 6bp del/ins, GGH-401C>T, MDR1 C3435T, hepatotoxicity predictors of methotrexate in patients with rheumatoid arthritis. Materials and methods : the frequency of liver dysfunction in 85 patients with rheumatoid arthritis was analyzed retrospectively with methotrexate therapy, followed by an assessment of the correlation with allelic polymorphisms of the folate cycle genes that regulate the diff erent stages of drug biotransformation. Results : an analysis of the distribution of alleles and genotypes of the folate cycle genes mentioned above allowed the identifi cation of protective genetic markers for methotrexate-induced hepatotoxicity in the form of allelic polymorphisms MTHFR1298AC and TS6bp del/ins, as well as suggesting the role of TS6bp ins/ins polymorphism in the development of hyperfermentemia. Conclusion : the ambiguity of the literature data on the search for prognostic markers of hepatotoxicity of methotrexate, as well as our data, which do not have comparable results in both domestic and foreign publications, dictate the need to continue research on the safety of methotrexate in rheumatoid arthritis." @default.
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- W3047564846 date "2020-08-04" @default.
- W3047564846 modified "2023-09-23" @default.
- W3047564846 title "Polymorphisms of methotrexate metabolism genes—as predictors of its hepatotoxicity in rheumatoid arthritis" @default.
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- W3047564846 doi "https://doi.org/10.31146/1682-8658-ecg-178-6-106-111" @default.
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