FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047576444> ?p ?o ?g. }

• W3047576444 abstract "Background Women have decreased hemodialysis arteriovenous fistula (AVF) maturation and patency rates. We determined the mechanisms responsible for the sex‐specific differences in AVF maturation and stenosis formation by performing whole transcriptome RNA sequencing with differential gene expression and pathway analysis, histopathological changes, and in vitro cell culture experiments from male and female smooth muscle cells. Methods and Results Mice with chronic kidney disease and AVF were used. Outflow veins were evaluated for gene expression, histomorphometric analysis, Doppler ultrasound, immunohistologic analysis, and fibrosis. Primary vascular smooth muscle cells were collected from female and male aorta vessels. In female AVFs, RNA sequencing with real‐time polymerase chain reaction analysis demonstrated a significant decrease in the average gene expression of BMP7 (bone morphogenetic protein 7) and downstream IL17Rb (interleukin 17 receptor b) , with increased transforming growth factor‐β1 ( Tgf‐β1) and transforming growth factor‐β receptor 1 ( Tgfβ‐r1) . There was decreased peak velocity, negative vascular remodeling with higher venous fibrosis and an increase in synthetic vascular smooth muscle cell phenotype, decrease in proliferation, and increase in apoptosis in female outflow veins at day 28. In vitro primary vascular smooth muscle cell experiments performed under hypoxic conditions demonstrated, in female compared with male cells, that there was increased gene expression of Tgf‐β1 , Tgfβ‐r1 , and Col1 with increased migration. Conclusions In female AVFs, there is decreased gene expression of BMP7 and IL17Rb with increased Tgf‐β1 and Tgfβ‐r1 , and the cellular and vascular differences result in venous fibrosis with negative vascular remodeling." @default.
• W3047576444 created "2020-08-10" @default.
• W3047576444 creator A5005572815 @default.
• W3047576444 creator A5041508925 @default.
• W3047576444 creator A5068512231 @default.
• W3047576444 creator A5069571516 @default.
• W3047576444 creator A5072703194 @default.
• W3047576444 creator A5083461986 @default.
• W3047576444 creator A5088234648 @default.
• W3047576444 creator A5090853382 @default.
• W3047576444 date "2020-08-18" @default.
• W3047576444 modified "2023-10-18" @default.
• W3047576444 title "Differences in Transforming Growth Factor‐β1/BMP7 Signaling and Venous Fibrosis Contribute to Female Sex Differences in Arteriovenous Fistulas" @default.
• W3047576444 cites W1503466466 @default.
• W3047576444 cites W1968416941 @default.
• W3047576444 cites W1974974082 @default.
• W3047576444 cites W1979187236 @default.
• W3047576444 cites W1989506680 @default.
• W3047576444 cites W2001004568 @default.
• W3047576444 cites W2015977407 @default.
• W3047576444 cites W2016065666 @default.
• W3047576444 cites W2024935147 @default.
• W3047576444 cites W2026034610 @default.
• W3047576444 cites W2051874953 @default.
• W3047576444 cites W2057313188 @default.
• W3047576444 cites W2067212840 @default.
• W3047576444 cites W2071853270 @default.
• W3047576444 cites W2073235331 @default.
• W3047576444 cites W2086222825 @default.
• W3047576444 cites W2097443346 @default.
• W3047576444 cites W2102941647 @default.
• W3047576444 cites W2115223685 @default.
• W3047576444 cites W2128987179 @default.
• W3047576444 cites W2131465979 @default.
• W3047576444 cites W2146519773 @default.
• W3047576444 cites W2150548551 @default.
• W3047576444 cites W2170434509 @default.
• W3047576444 cites W2272233471 @default.
• W3047576444 cites W2513147643 @default.
• W3047576444 cites W2782685791 @default.
• W3047576444 cites W2801293053 @default.
• W3047576444 cites W2915165159 @default.
• W3047576444 cites W2923956616 @default.
• W3047576444 cites W2954429932 @default.
• W3047576444 cites W2983691809 @default.
• W3047576444 cites W2996581119 @default.
• W3047576444 cites W4239965812 @default.
• W3047576444 cites W4256509992 @default.
• W3047576444 doi "https://doi.org/10.1161/jaha.120.017420" @default.
• W3047576444 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7660821" @default.
• W3047576444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32757791" @default.
• W3047576444 hasPublicationYear "2020" @default.
• W3047576444 type Work @default.
• W3047576444 sameAs 3047576444 @default.
• W3047576444 citedByCount "20" @default.
• W3047576444 countsByYear W30475764442020 @default.
• W3047576444 countsByYear W30475764442021 @default.
• W3047576444 countsByYear W30475764442022 @default.
• W3047576444 countsByYear W30475764442023 @default.
• W3047576444 crossrefType "journal-article" @default.
• W3047576444 hasAuthorship W3047576444A5005572815 @default.
• W3047576444 hasAuthorship W3047576444A5041508925 @default.
• W3047576444 hasAuthorship W3047576444A5068512231 @default.
• W3047576444 hasAuthorship W3047576444A5069571516 @default.
• W3047576444 hasAuthorship W3047576444A5072703194 @default.
• W3047576444 hasAuthorship W3047576444A5083461986 @default.
• W3047576444 hasAuthorship W3047576444A5088234648 @default.
• W3047576444 hasAuthorship W3047576444A5090853382 @default.
• W3047576444 hasBestOaLocation W30475764441 @default.
• W3047576444 hasConcept C10205521 @default.
• W3047576444 hasConcept C104317684 @default.
• W3047576444 hasConcept C118131993 @default.
• W3047576444 hasConcept C126322002 @default.
• W3047576444 hasConcept C134018914 @default.
• W3047576444 hasConcept C141071460 @default.
• W3047576444 hasConcept C142724271 @default.
• W3047576444 hasConcept C150194340 @default.
• W3047576444 hasConcept C162317418 @default.
• W3047576444 hasConcept C167734588 @default.
• W3047576444 hasConcept C170493617 @default.
• W3047576444 hasConcept C2775960820 @default.
• W3047576444 hasConcept C2777025900 @default.
• W3047576444 hasConcept C2778229498 @default.
• W3047576444 hasConcept C2779063477 @default.
• W3047576444 hasConcept C2779395532 @default.
• W3047576444 hasConcept C2780559512 @default.
• W3047576444 hasConcept C28328180 @default.
• W3047576444 hasConcept C2992686903 @default.
• W3047576444 hasConcept C55493867 @default.
• W3047576444 hasConcept C6061869 @default.
• W3047576444 hasConcept C71924100 @default.
• W3047576444 hasConcept C86803240 @default.
• W3047576444 hasConcept C95444343 @default.
• W3047576444 hasConceptScore W3047576444C10205521 @default.
• W3047576444 hasConceptScore W3047576444C104317684 @default.
• W3047576444 hasConceptScore W3047576444C118131993 @default.
• W3047576444 hasConceptScore W3047576444C126322002 @default.
• W3047576444 hasConceptScore W3047576444C134018914 @default.
• W3047576444 hasConceptScore W3047576444C141071460 @default.
• W3047576444 hasConceptScore W3047576444C142724271 @default.

• next