Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047577234> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W3047577234 abstract "Context Type 1 diabetes in adolescence is characterized by insulin deficiency and insulin resistance (IR), both thought to increase cardiovascular disease risk. We previously demonstrated that adolescents with type 1 diabetes have adipose, hepatic, and muscle IR, and that metformin lowers daily insulin dose, suggesting improved IR. However, whether metformin improves IR in muscle, hepatic, or adipose tissues in type 1 diabetes was unknown. Objective Measure peripheral, hepatic, and adipose insulin sensitivity before and after metformin or placebo therapy in youth with obesity with type 1 diabetes. Design Double-blind, placebo-controlled clinical trial. Setting Multi-center at eight sites of the T1D Exchange Clinic Network. Participants A subset of 12- to 19-year-olds with type 1 diabetes (inclusion criteria: body mass index ≥85th percentile, HbA1c 7.5% to 9.9%, insulin dosing ≥0.8 U/kg/d) from a larger trial (NCT02045290) were enrolled. Intervention Participants were randomized to 3 months of metformin (N = 19) or placebo (N = 18) and underwent a three-phase hyperinsulinemic euglycemic clamp with glucose and glycerol isotope tracers to assess tissue-specific IR before and after treatment. Main outcome measures Peripheral insulin sensitivity, endogenous glucose release, rate of lipolysis. Results Between-group differences in change in insulin sensitivity favored metformin regarding whole-body IR [change in glucose infusion rate 1.3 (0.1, 2.4) mg/kg/min, P = 0.03] and peripheral IR [change in metabolic clearance rate 0.923 (-0.002, 1.867) dL/kg/min, P = 0.05]. Metformin did not impact insulin suppression of endogenous glucose release (P = 0.12). Adipose IR was not assessable with traditional methods in this highly IR population. Conclusions Metformin appears to improve whole-body and peripheral IR in youth who are overweight/obese with type 1 diabetes." @default.
- W3047577234 created "2020-08-10" @default.
- W3047577234 creator A5003509702 @default.
- W3047577234 creator A5004012559 @default.
- W3047577234 creator A5005491526 @default.
- W3047577234 creator A5007539245 @default.
- W3047577234 creator A5024638744 @default.
- W3047577234 creator A5031541043 @default.
- W3047577234 creator A5044457781 @default.
- W3047577234 creator A5060820457 @default.
- W3047577234 creator A5066814097 @default.
- W3047577234 creator A5068790110 @default.
- W3047577234 creator A5071275113 @default.
- W3047577234 creator A5084783616 @default.
- W3047577234 creator A5085272298 @default.
- W3047577234 creator A5086928894 @default.
- W3047577234 date "2019-08-01" @default.
- W3047577234 modified "2023-09-26" @default.
- W3047577234 title "Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes" @default.
- W3047577234 hasPublicationYear "2019" @default.
- W3047577234 type Work @default.
- W3047577234 sameAs 3047577234 @default.
- W3047577234 citedByCount "0" @default.
- W3047577234 crossrefType "journal-article" @default.
- W3047577234 hasAuthorship W3047577234A5003509702 @default.
- W3047577234 hasAuthorship W3047577234A5004012559 @default.
- W3047577234 hasAuthorship W3047577234A5005491526 @default.
- W3047577234 hasAuthorship W3047577234A5007539245 @default.
- W3047577234 hasAuthorship W3047577234A5024638744 @default.
- W3047577234 hasAuthorship W3047577234A5031541043 @default.
- W3047577234 hasAuthorship W3047577234A5044457781 @default.
- W3047577234 hasAuthorship W3047577234A5060820457 @default.
- W3047577234 hasAuthorship W3047577234A5066814097 @default.
- W3047577234 hasAuthorship W3047577234A5068790110 @default.
- W3047577234 hasAuthorship W3047577234A5071275113 @default.
- W3047577234 hasAuthorship W3047577234A5084783616 @default.
- W3047577234 hasAuthorship W3047577234A5085272298 @default.
- W3047577234 hasAuthorship W3047577234A5086928894 @default.
- W3047577234 hasConcept C126322002 @default.
- W3047577234 hasConcept C134018914 @default.
- W3047577234 hasConcept C142724271 @default.
- W3047577234 hasConcept C151730666 @default.
- W3047577234 hasConcept C171089720 @default.
- W3047577234 hasConcept C204787440 @default.
- W3047577234 hasConcept C27081682 @default.
- W3047577234 hasConcept C2777180221 @default.
- W3047577234 hasConcept C2777391703 @default.
- W3047577234 hasConcept C2778808658 @default.
- W3047577234 hasConcept C2779306644 @default.
- W3047577234 hasConcept C2779343474 @default.
- W3047577234 hasConcept C2780323712 @default.
- W3047577234 hasConcept C2780352109 @default.
- W3047577234 hasConcept C555293320 @default.
- W3047577234 hasConcept C71924100 @default.
- W3047577234 hasConcept C86803240 @default.
- W3047577234 hasConceptScore W3047577234C126322002 @default.
- W3047577234 hasConceptScore W3047577234C134018914 @default.
- W3047577234 hasConceptScore W3047577234C142724271 @default.
- W3047577234 hasConceptScore W3047577234C151730666 @default.
- W3047577234 hasConceptScore W3047577234C171089720 @default.
- W3047577234 hasConceptScore W3047577234C204787440 @default.
- W3047577234 hasConceptScore W3047577234C27081682 @default.
- W3047577234 hasConceptScore W3047577234C2777180221 @default.
- W3047577234 hasConceptScore W3047577234C2777391703 @default.
- W3047577234 hasConceptScore W3047577234C2778808658 @default.
- W3047577234 hasConceptScore W3047577234C2779306644 @default.
- W3047577234 hasConceptScore W3047577234C2779343474 @default.
- W3047577234 hasConceptScore W3047577234C2780323712 @default.
- W3047577234 hasConceptScore W3047577234C2780352109 @default.
- W3047577234 hasConceptScore W3047577234C555293320 @default.
- W3047577234 hasConceptScore W3047577234C71924100 @default.
- W3047577234 hasConceptScore W3047577234C86803240 @default.
- W3047577234 hasLocation W30475772341 @default.
- W3047577234 hasOpenAccess W3047577234 @default.
- W3047577234 hasPrimaryLocation W30475772341 @default.
- W3047577234 hasRelatedWork W11872906 @default.
- W3047577234 hasRelatedWork W1939677357 @default.
- W3047577234 hasRelatedWork W1967504606 @default.
- W3047577234 hasRelatedWork W1968794674 @default.
- W3047577234 hasRelatedWork W1987342027 @default.
- W3047577234 hasRelatedWork W1991925603 @default.
- W3047577234 hasRelatedWork W2010801966 @default.
- W3047577234 hasRelatedWork W2051135812 @default.
- W3047577234 hasRelatedWork W2067041149 @default.
- W3047577234 hasRelatedWork W2071133398 @default.
- W3047577234 hasRelatedWork W2352728416 @default.
- W3047577234 hasRelatedWork W2372358031 @default.
- W3047577234 hasRelatedWork W2413057599 @default.
- W3047577234 hasRelatedWork W2533124895 @default.
- W3047577234 hasRelatedWork W2763427853 @default.
- W3047577234 hasRelatedWork W2784321962 @default.
- W3047577234 hasRelatedWork W2932901353 @default.
- W3047577234 hasRelatedWork W3047938855 @default.
- W3047577234 hasRelatedWork W3151500052 @default.
- W3047577234 hasRelatedWork W59245018 @default.
- W3047577234 isParatext "false" @default.
- W3047577234 isRetracted "false" @default.
- W3047577234 magId "3047577234" @default.
- W3047577234 workType "article" @default.