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- W3047583174 abstract "Stimuli-responsive nanoparticles based on a reactive block copolymers (BCPs) of poly(ethylene glycol)-b-poly(2-vinyl-4,4-dimethylazlactone) (PEG-b-PVDMA) have been fabricated for loading and controlled release of molecular cargoes. Microphase segregation of PEG-b-PVDMA BCPs enables the construction of well-defined nanoparticles in aqueous solutions. The azlactone groups in VDMA repeat units offer active sites for hydrophilization of the BCPs and functionalization by primary amines. The hydrophilization of PEG-b-PVDMA BCPs induces gradual reconstruction and dissociation of the BCP nanoparticles. Functional primary amines can be conjugated to PEG-b-PVDMA BCPs, yielding azobenzene- and pyridine-containing BCPs. The self-assembled nanoparticles made from the functionalized BCPs can disassemble in response to different external stimuli (e.g., addition of β-cyclodextrin and pH changes). The gradual reconstruction of functionalized PEG-b-PVDMA BCP nanoparticles caused by hydrolysis of residual azlactone groups provides a novel method to engineer sub-50 nm, well-dispersed, stimuli-responsive nanoparticles. These nanoparticles can incorporate molecular cargoes and release them upon external stimuli, making the azlactone-containing BCPs attractive platforms for the development of controlled delivery vehicles." @default.
- W3047583174 created "2020-08-10" @default.
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- W3047583174 date "2020-08-03" @default.
- W3047583174 modified "2023-09-27" @default.
- W3047583174 title "Tailoring Azlactone-Based Block Copolymers for Stimuli-Responsive Disassembly of Nanocarriers" @default.
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- W3047583174 doi "https://doi.org/10.1021/acs.langmuir.0c01681" @default.
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