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- W3047593375 abstract "Morphine and oxycodone are two clinically used strong opioids. Chronic treatment with oxycodone as well as morphine can lead to analgesic tolerance and paradoxical hyperalgesia. Here we show that an N-methyl-d-aspartate receptor-dependent pronociceptive change in discharge properties of rostroventromedial medullary neurons controlling spinal nociception has an important role in antinociceptive tolerance to morphine but not oxycodone. Interestingly, chronic oxycodone did not induce pronociceptive changes in the rostroventromedial medulla." @default.
- W3047593375 created "2020-08-10" @default.
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- W3047593375 date "2020-09-01" @default.
- W3047593375 modified "2023-10-18" @default.
- W3047593375 title "Neurophysiological response properties of medullary pain-control neurons following chronic treatment with morphine or oxycodone: modulation by acute ketamine" @default.
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- W3047593375 doi "https://doi.org/10.1152/jn.00343.2020" @default.
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