Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047640655> ?p ?o ?g. }
- W3047640655 abstract "Hepatitis B virus (HBV) can establish a lifelong chronic infection in humans, leading to liver cirrhosis, liver failure and hepatocellular carcinoma. Patients with chronic hepatitis B (CHB) exhibit a weak virus-specific immune response. Regulatory T cells (Tregs) play a key role in regulating the immune response in patients with CHB. Patients with hepatitis B envelope antigen (HBeAg)-positive CHB harbored a higher percentage of Tregs in their peripheral blood than those with HBeAg-negative CHB. However, whether and how HBeAg manipulates the host immune system to increase the population of Tregs remains to be elucidated. The present manuscript describes a preliminary immunological study of HBeAg in a mouse model. Multiple potential CD4+ T cell epitopes in HBeAg were identified using Immune Epitope Database consensus binding prediction. It was demonstrated that HBeAg treatment increased the numbers of Tregs in mouse spleens in vitro and in vivo. Furthermore, it was indicated that the HBeAg-mediated increase in Tregs occurred through the conversion of CD4+CD25- T cells into CD4+CD25+Foxp3+ Tregs. Additionally, in vitro study illustrated that HBeAg stimulated murine spleen cells to produce increased transforming growth factor-β, which is required to enable HBeAg to convert T cells into Tregs. The results of the present study may provide further evidence of the effect of HBeAg on Tregs and aid in the development of novel HBeAg-based immunotherapy for CHB." @default.
- W3047640655 created "2020-08-13" @default.
- W3047640655 creator A5009138493 @default.
- W3047640655 creator A5011163766 @default.
- W3047640655 creator A5012008900 @default.
- W3047640655 creator A5032560997 @default.
- W3047640655 creator A5036974410 @default.
- W3047640655 creator A5048976159 @default.
- W3047640655 creator A5053417566 @default.
- W3047640655 creator A5062382250 @default.
- W3047640655 creator A5065003478 @default.
- W3047640655 creator A5078152957 @default.
- W3047640655 creator A5078591588 @default.
- W3047640655 creator A5091473946 @default.
- W3047640655 date "2020-08-06" @default.
- W3047640655 modified "2023-09-26" @default.
- W3047640655 title "Hepatitis B envelope antigen increases Tregs by converting CD4+CD25‑ T cells into CD4+CD25+Foxp3+ Tregs" @default.
- W3047640655 cites W1569611860 @default.
- W3047640655 cites W1762842652 @default.
- W3047640655 cites W1859239181 @default.
- W3047640655 cites W1978656930 @default.
- W3047640655 cites W1985970818 @default.
- W3047640655 cites W2013601398 @default.
- W3047640655 cites W2014489332 @default.
- W3047640655 cites W2023038954 @default.
- W3047640655 cites W2032178518 @default.
- W3047640655 cites W2033695252 @default.
- W3047640655 cites W2042227130 @default.
- W3047640655 cites W2048056516 @default.
- W3047640655 cites W2058636963 @default.
- W3047640655 cites W2073389228 @default.
- W3047640655 cites W2074174373 @default.
- W3047640655 cites W2084152099 @default.
- W3047640655 cites W2102838538 @default.
- W3047640655 cites W2103338170 @default.
- W3047640655 cites W2110735100 @default.
- W3047640655 cites W2120010406 @default.
- W3047640655 cites W2128235127 @default.
- W3047640655 cites W2132216539 @default.
- W3047640655 cites W2140382373 @default.
- W3047640655 cites W2141649011 @default.
- W3047640655 cites W2156104527 @default.
- W3047640655 cites W2166849716 @default.
- W3047640655 cites W2267571233 @default.
- W3047640655 cites W2332517313 @default.
- W3047640655 cites W2481374159 @default.
- W3047640655 cites W2735805106 @default.
- W3047640655 cites W2750133790 @default.
- W3047640655 cites W2755711848 @default.
- W3047640655 cites W2786264829 @default.
- W3047640655 cites W2885169669 @default.
- W3047640655 cites W2900781853 @default.
- W3047640655 cites W2937115869 @default.
- W3047640655 doi "https://doi.org/10.3892/etm.2020.9107" @default.
- W3047640655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7444405" @default.
- W3047640655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32855720" @default.
- W3047640655 hasPublicationYear "2020" @default.
- W3047640655 type Work @default.
- W3047640655 sameAs 3047640655 @default.
- W3047640655 citedByCount "6" @default.
- W3047640655 countsByYear W30476406552021 @default.
- W3047640655 countsByYear W30476406552022 @default.
- W3047640655 countsByYear W30476406552023 @default.
- W3047640655 crossrefType "journal-article" @default.
- W3047640655 hasAuthorship W3047640655A5009138493 @default.
- W3047640655 hasAuthorship W3047640655A5011163766 @default.
- W3047640655 hasAuthorship W3047640655A5012008900 @default.
- W3047640655 hasAuthorship W3047640655A5032560997 @default.
- W3047640655 hasAuthorship W3047640655A5036974410 @default.
- W3047640655 hasAuthorship W3047640655A5048976159 @default.
- W3047640655 hasAuthorship W3047640655A5053417566 @default.
- W3047640655 hasAuthorship W3047640655A5062382250 @default.
- W3047640655 hasAuthorship W3047640655A5065003478 @default.
- W3047640655 hasAuthorship W3047640655A5078152957 @default.
- W3047640655 hasAuthorship W3047640655A5078591588 @default.
- W3047640655 hasAuthorship W3047640655A5091473946 @default.
- W3047640655 hasBestOaLocation W30476406551 @default.
- W3047640655 hasConcept C159047783 @default.
- W3047640655 hasConcept C203014093 @default.
- W3047640655 hasConcept C2522874641 @default.
- W3047640655 hasConcept C2775940106 @default.
- W3047640655 hasConcept C2776090121 @default.
- W3047640655 hasConcept C2777410769 @default.
- W3047640655 hasConcept C2777701055 @default.
- W3047640655 hasConcept C2779727006 @default.
- W3047640655 hasConcept C2780593183 @default.
- W3047640655 hasConcept C71924100 @default.
- W3047640655 hasConcept C79484868 @default.
- W3047640655 hasConcept C86803240 @default.
- W3047640655 hasConcept C8891405 @default.
- W3047640655 hasConceptScore W3047640655C159047783 @default.
- W3047640655 hasConceptScore W3047640655C203014093 @default.
- W3047640655 hasConceptScore W3047640655C2522874641 @default.
- W3047640655 hasConceptScore W3047640655C2775940106 @default.
- W3047640655 hasConceptScore W3047640655C2776090121 @default.
- W3047640655 hasConceptScore W3047640655C2777410769 @default.
- W3047640655 hasConceptScore W3047640655C2777701055 @default.
- W3047640655 hasConceptScore W3047640655C2779727006 @default.
- W3047640655 hasConceptScore W3047640655C2780593183 @default.
- W3047640655 hasConceptScore W3047640655C71924100 @default.