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• W3047665105 abstract "Alport syndrome affects up to 60,000 people in the United States. The proposed reclassification of thin basement membrane nephropathy and some cases of focal segmental glomerulosclerosis as Alport syndrome could substantially increase the affected population. The reclassification scheme categorizes Alport syndrome as 3 distinct diseases of type IV collagen α3/4/5 based on a genetic evaluation: X-linked, autosomal, and digenic. This approach has the advantage of identifying patients at risk for progressive loss of kidney function. Furthermore, the shared molecular cause of Alport syndrome and thin basement membrane nephropathy arises from mutations in the COL4A3, COL4A4, and COL4A5 genes, which contribute to downstream pathophysiologic consequences, including chronic kidney inflammation. Recent evidence indicates that chronic inflammation and its regulation through anti-inflammatory nuclear factor erythroid 2-related factor 2 (Nrf2) and proinflammatory nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) transcription factors plays a central role in renal tubular and glomerular cell responses to injury. Crosstalk between the Nrf2 and NF-κB pathways is important in the regulation of inflammation in patients with chronic kidney disease; moreover, there is evidence that an insufficient Nrf2 response to inflammation contributes to disease progression. Given the association between type IV collagen abnormalities and chronic inflammation, there is renewed interest in targeted anti-inflammatory therapies in Alport syndrome and other forms of progressive chronic kidney disease." @default.
• W3047665105 created "2020-08-13" @default.
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• W3047665105 date "2020-09-01" @default.
• W3047665105 modified "2023-10-02" @default.
• W3047665105 title "Alport Syndrome Classification and Management" @default.
• W3047665105 cites W1584309458 @default.
• W3047665105 cites W1586694827 @default.
• W3047665105 cites W1785455093 @default.
• W3047665105 cites W1969338661 @default.
• W3047665105 cites W1971604855 @default.
• W3047665105 cites W1973471682 @default.
• W3047665105 cites W1973882427 @default.
• W3047665105 cites W1975238931 @default.
• W3047665105 cites W1977736016 @default.
• W3047665105 cites W19843932 @default.
• W3047665105 cites W1994943781 @default.
• W3047665105 cites W2002286106 @default.
• W3047665105 cites W2008100303 @default.
• W3047665105 cites W2018079417 @default.
• W3047665105 cites W2025914300 @default.
• W3047665105 cites W2028670169 @default.
• W3047665105 cites W2029433163 @default.
• W3047665105 cites W2030164790 @default.
• W3047665105 cites W2031477290 @default.
• W3047665105 cites W2034698282 @default.
• W3047665105 cites W2036377154 @default.
• W3047665105 cites W2036762604 @default.
• W3047665105 cites W2058691614 @default.
• W3047665105 cites W2059709989 @default.
• W3047665105 cites W2064452102 @default.
• W3047665105 cites W2068050227 @default.
• W3047665105 cites W2073716079 @default.
• W3047665105 cites W2074207450 @default.
• W3047665105 cites W2075685041 @default.
• W3047665105 cites W2087417855 @default.
• W3047665105 cites W2087509925 @default.
• W3047665105 cites W2087627594 @default.
• W3047665105 cites W2092634305 @default.
• W3047665105 cites W2097888088 @default.
• W3047665105 cites W2099530258 @default.
• W3047665105 cites W2101590985 @default.
• W3047665105 cites W2102572041 @default.
• W3047665105 cites W2103188558 @default.
• W3047665105 cites W2106469735 @default.
• W3047665105 cites W2113024198 @default.
• W3047665105 cites W2114008865 @default.
• W3047665105 cites W2124964208 @default.
• W3047665105 cites W2126146739 @default.
• W3047665105 cites W2127719372 @default.
• W3047665105 cites W2128796050 @default.
• W3047665105 cites W2131738077 @default.
• W3047665105 cites W2143156113 @default.
• W3047665105 cites W2152238541 @default.
• W3047665105 cites W2158458517 @default.
• W3047665105 cites W2165093564 @default.
• W3047665105 cites W2167175000 @default.
• W3047665105 cites W2171439919 @default.
• W3047665105 cites W2172759855 @default.
• W3047665105 cites W2189612961 @default.
• W3047665105 cites W2224089884 @default.
• W3047665105 cites W2335925695 @default.
• W3047665105 cites W2338584425 @default.
• W3047665105 cites W2361569450 @default.
• W3047665105 cites W2400239628 @default.
• W3047665105 cites W2409753686 @default.
• W3047665105 cites W2418270501 @default.
• W3047665105 cites W2574644607 @default.
• W3047665105 cites W2604064468 @default.
• W3047665105 cites W2613483874 @default.
• W3047665105 cites W2623546284 @default.
• W3047665105 cites W2735527928 @default.
• W3047665105 cites W2736212635 @default.
• W3047665105 cites W2772570025 @default.
• W3047665105 cites W2792067435 @default.
• W3047665105 cites W2792733174 @default.
• W3047665105 cites W2827559089 @default.
• W3047665105 cites W2888346415 @default.
• W3047665105 cites W2890248806 @default.
• W3047665105 cites W2897293647 @default.
• W3047665105 cites W2906428833 @default.
• W3047665105 cites W2909726367 @default.
• W3047665105 cites W2961829627 @default.
• W3047665105 cites W3150595609 @default.
• W3047665105 cites W4294540886 @default.
• W3047665105 cites W952491933 @default.
• W3047665105 doi "https://doi.org/10.1016/j.xkme.2020.05.014" @default.
• W3047665105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7568086" @default.
• W3047665105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33094278" @default.
• W3047665105 hasPublicationYear "2020" @default.
• W3047665105 type Work @default.

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