FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3047665455> ?p ?o ?g. }

• W3047665455 endingPage "339" @default.
• W3047665455 startingPage "331" @default.
• W3047665455 abstract "Depression is highly prevalent worldwide and the leading cause of disability. It is believed that currently more than 300 million people of all ages suffer from depression. However, the unambiguous cause of the depression remains unknown. It is suggested that the occurrence of this disease is primarily affected by genetic factors, psychological factors and atypical brain structure or function. Recently, an increasingly important role is attributed to the inflammatory response, which is considered to be the main cause of depression. Activation of the kynurenine pathway (KP) is one of the described mechanisms by which inflammation can induce depression. Kynurenine pathway activation is associated with several neuropsychiatric diseases, including major depression disorder (MDD). The imbalance between the neuroprotective and neurotoxic metabolites in the kynurenine pathway and the associated serotonin and melatonin deficiency, may contribute to the manifestation of depressive symptoms. In this review we discuss the role of the major enzymes of the tryptophan KP: tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) and the role of selected kynurenic metabolites in the depressive disorders. Particular attention was also paid to the genetic basis of depressive disorders and to the summary of current knowledge on the effectiveness of treatment and supplementation with tryptophan and 5-hydroxytryptophan in depression." @default.
• W3047665455 created "2020-08-13" @default.
• W3047665455 creator A5006712038 @default.
• W3047665455 creator A5031143283 @default.
• W3047665455 creator A5045567805 @default.
• W3047665455 date "2020-08-06" @default.
• W3047665455 modified "2023-10-17" @default.
• W3047665455 title "Kynurenine pathway: the link between depressive disorders and inflammation" @default.
• W3047665455 cites W1530111369 @default.
• W3047665455 cites W1547937746 @default.
• W3047665455 cites W1964709968 @default.
• W3047665455 cites W1975778730 @default.
• W3047665455 cites W1977489472 @default.
• W3047665455 cites W1978830885 @default.
• W3047665455 cites W1994455271 @default.
• W3047665455 cites W2022766686 @default.
• W3047665455 cites W2025485131 @default.
• W3047665455 cites W2047739268 @default.
• W3047665455 cites W2051353156 @default.
• W3047665455 cites W2075618111 @default.
• W3047665455 cites W2076277579 @default.
• W3047665455 cites W2078617766 @default.
• W3047665455 cites W2098120777 @default.
• W3047665455 cites W2146758523 @default.
• W3047665455 cites W2162091209 @default.
• W3047665455 cites W2611951655 @default.
• W3047665455 cites W2741302852 @default.
• W3047665455 cites W2901161099 @default.
• W3047665455 cites W2901341981 @default.
• W3047665455 cites W2954367215 @default.
• W3047665455 cites W4210489131 @default.
• W3047665455 doi "https://doi.org/10.5604/01.3001.0014.3454" @default.
• W3047665455 hasPublicationYear "2020" @default.
• W3047665455 type Work @default.
• W3047665455 sameAs 3047665455 @default.
• W3047665455 citedByCount "3" @default.
• W3047665455 countsByYear W30476654552021 @default.
• W3047665455 countsByYear W30476654552022 @default.
• W3047665455 crossrefType "journal-article" @default.
• W3047665455 hasAuthorship W3047665455A5006712038 @default.
• W3047665455 hasAuthorship W3047665455A5031143283 @default.
• W3047665455 hasAuthorship W3047665455A5045567805 @default.
• W3047665455 hasConcept C118552586 @default.
• W3047665455 hasConcept C126322002 @default.
• W3047665455 hasConcept C139719470 @default.
• W3047665455 hasConcept C15744967 @default.
• W3047665455 hasConcept C162324750 @default.
• W3047665455 hasConcept C169900460 @default.
• W3047665455 hasConcept C170493617 @default.
• W3047665455 hasConcept C25498285 @default.
• W3047665455 hasConcept C2775864247 @default.
• W3047665455 hasConcept C2776706248 @default.
• W3047665455 hasConcept C2776710720 @default.
• W3047665455 hasConcept C2776841986 @default.
• W3047665455 hasConcept C2776867660 @default.
• W3047665455 hasConcept C2776914184 @default.
• W3047665455 hasConcept C2777503454 @default.
• W3047665455 hasConcept C2779134260 @default.
• W3047665455 hasConcept C2780051608 @default.
• W3047665455 hasConcept C515207424 @default.
• W3047665455 hasConcept C54355233 @default.
• W3047665455 hasConcept C60644358 @default.
• W3047665455 hasConcept C61174792 @default.
• W3047665455 hasConcept C71924100 @default.
• W3047665455 hasConcept C83478079 @default.
• W3047665455 hasConcept C86803240 @default.
• W3047665455 hasConceptScore W3047665455C118552586 @default.
• W3047665455 hasConceptScore W3047665455C126322002 @default.
• W3047665455 hasConceptScore W3047665455C139719470 @default.
• W3047665455 hasConceptScore W3047665455C15744967 @default.
• W3047665455 hasConceptScore W3047665455C162324750 @default.
• W3047665455 hasConceptScore W3047665455C169900460 @default.
• W3047665455 hasConceptScore W3047665455C170493617 @default.
• W3047665455 hasConceptScore W3047665455C25498285 @default.
• W3047665455 hasConceptScore W3047665455C2775864247 @default.
• W3047665455 hasConceptScore W3047665455C2776706248 @default.
• W3047665455 hasConceptScore W3047665455C2776710720 @default.
• W3047665455 hasConceptScore W3047665455C2776841986 @default.
• W3047665455 hasConceptScore W3047665455C2776867660 @default.
• W3047665455 hasConceptScore W3047665455C2776914184 @default.
• W3047665455 hasConceptScore W3047665455C2777503454 @default.
• W3047665455 hasConceptScore W3047665455C2779134260 @default.
• W3047665455 hasConceptScore W3047665455C2780051608 @default.
• W3047665455 hasConceptScore W3047665455C515207424 @default.
• W3047665455 hasConceptScore W3047665455C54355233 @default.
• W3047665455 hasConceptScore W3047665455C60644358 @default.
• W3047665455 hasConceptScore W3047665455C61174792 @default.
• W3047665455 hasConceptScore W3047665455C71924100 @default.
• W3047665455 hasConceptScore W3047665455C83478079 @default.
• W3047665455 hasConceptScore W3047665455C86803240 @default.
• W3047665455 hasLocation W30476654551 @default.
• W3047665455 hasOpenAccess W3047665455 @default.
• W3047665455 hasPrimaryLocation W30476654551 @default.
• W3047665455 hasRelatedWork W1814809256 @default.
• W3047665455 hasRelatedWork W1897071989 @default.
• W3047665455 hasRelatedWork W1983949227 @default.
• W3047665455 hasRelatedWork W1990286385 @default.
• W3047665455 hasRelatedWork W2037046106 @default.

• next