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- W3047700115 abstract "Sepsis is an aberrant systemic inflammatory response mediated by excessive production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Developing an efficient antioxidant therapy for sepsis via scavenging ROS and RNS remains a big challenge owing to the insufficient activity and sustainability of conventional antioxidants. Herein, biocompatible transition-metal dichalcogenide antioxidants with excellent scavenging activity and sustainability for H2O2, O2•-, OH•, and nitric oxide are developed for effective sepsis treatment. WS2, MoSe2, and WSe2 nanosheets exfoliated and functionalized with a biocompatible polymer effectively scavenge mitochondrial and intracellular ROS and RNS in inflammatory cells. Among the nanosheets, WS2 most efficiently suppresses the excessive secretion of inflammatory cytokines along with scavenging ROS and RNS without affecting the expression levels of the anti-inflammatory cytokine and ROS-producing enzymes. The WS2 nanosheets significantly improve the survival rate up to 90% for severely septic mice by reducing systemic inflammation. The pharmacokinetics suggests that the WS2 nanosheets can be excreted from mice 3 days after intravenous injection. This work demonstrates the potential of therapeutic nanosheet antioxidants for effective treatment of ROS and RNS-related diseases." @default.
- W3047700115 created "2020-08-13" @default.
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- W3047700115 date "2020-08-07" @default.
- W3047700115 modified "2023-10-17" @default.
- W3047700115 title "Sustainable Nanosheet Antioxidants for Sepsis Therapy <i>via</i> Scavenging Intracellular Reactive Oxygen and Nitrogen Species" @default.
- W3047700115 cites W1918295515 @default.
- W3047700115 cites W1969314684 @default.
- W3047700115 cites W1979059006 @default.
- W3047700115 cites W1981243375 @default.
- W3047700115 cites W1981539053 @default.
- W3047700115 cites W1999476436 @default.
- W3047700115 cites W2011899447 @default.
- W3047700115 cites W2012991711 @default.
- W3047700115 cites W2034706788 @default.
- W3047700115 cites W2042685082 @default.
- W3047700115 cites W2043512927 @default.
- W3047700115 cites W2047720094 @default.
- W3047700115 cites W2058690999 @default.
- W3047700115 cites W2059821596 @default.
- W3047700115 cites W2065663588 @default.
- W3047700115 cites W2072232259 @default.
- W3047700115 cites W2073066847 @default.
- W3047700115 cites W2083516894 @default.
- W3047700115 cites W2083631490 @default.
- W3047700115 cites W2085537249 @default.
- W3047700115 cites W2088220499 @default.
- W3047700115 cites W2096254067 @default.
- W3047700115 cites W2105924651 @default.
- W3047700115 cites W2115786064 @default.
- W3047700115 cites W2122628753 @default.
- W3047700115 cites W2127274125 @default.
- W3047700115 cites W2141471352 @default.
- W3047700115 cites W2141678261 @default.
- W3047700115 cites W2168557396 @default.
- W3047700115 cites W2254898344 @default.
- W3047700115 cites W2280404143 @default.
- W3047700115 cites W2296523452 @default.
- W3047700115 cites W2308289470 @default.
- W3047700115 cites W2318484315 @default.
- W3047700115 cites W2319497083 @default.
- W3047700115 cites W2346116348 @default.
- W3047700115 cites W2398821041 @default.
- W3047700115 cites W2398986011 @default.
- W3047700115 cites W2404093368 @default.
- W3047700115 cites W2468355850 @default.
- W3047700115 cites W2555950347 @default.
- W3047700115 cites W2560240742 @default.
- W3047700115 cites W2562104100 @default.
- W3047700115 cites W2566562918 @default.
- W3047700115 cites W2625595950 @default.
- W3047700115 cites W2627001981 @default.
- W3047700115 cites W2689318812 @default.
- W3047700115 cites W2738043234 @default.
- W3047700115 cites W2756282825 @default.
- W3047700115 cites W2758339068 @default.
- W3047700115 cites W2766231696 @default.
- W3047700115 cites W2769808752 @default.
- W3047700115 cites W2772059695 @default.
- W3047700115 cites W2772143356 @default.
- W3047700115 cites W2785596761 @default.
- W3047700115 cites W2790477740 @default.
- W3047700115 cites W2790745617 @default.
- W3047700115 cites W2794719705 @default.
- W3047700115 cites W2794767916 @default.
- W3047700115 cites W2809333188 @default.
- W3047700115 cites W2811262040 @default.
- W3047700115 cites W2883268465 @default.
- W3047700115 cites W2885726045 @default.
- W3047700115 cites W2886656280 @default.
- W3047700115 cites W2889687924 @default.
- W3047700115 cites W2903236462 @default.
- W3047700115 cites W2905296697 @default.
- W3047700115 cites W2905491630 @default.
- W3047700115 cites W2920324197 @default.
- W3047700115 cites W2937889717 @default.
- W3047700115 cites W2939873693 @default.
- W3047700115 cites W2947510286 @default.
- W3047700115 cites W2947934753 @default.
- W3047700115 cites W2977459771 @default.
- W3047700115 cites W2998853022 @default.
- W3047700115 cites W3010534104 @default.
- W3047700115 cites W3021857066 @default.
- W3047700115 doi "https://doi.org/10.1021/acsnano.0c03807" @default.
- W3047700115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32806029" @default.
- W3047700115 hasPublicationYear "2020" @default.
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