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• W3047726430 abstract "Natural product biosynthesis (NPB) is the Panda's Thumb of evolutionary biochemistry. Arm races between organisms, and ever-changing environments, result in relentless innovation. This review focusses on enzyme evolution in NPB. First, we review cases of de novo emergence, whereby a completely new enzymatic activity arose in a ligand-binding protein, or a new enzyme emerged including a completely new scaffold. Second, we briefly review the current models for enzyme evolution, and how they explain the inherent promiscuity of NPB enzymes and their tendency to produce multiple related products. We thus suggest that NPB enzymes a priori evolved to generate a specific product; they are, however, trapped in a multifunctional, generalist evolutionary state and thereby produce a diversity of products." @default.
• W3047726430 created "2020-08-13" @default.
• W3047726430 creator A5027914375 @default.
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• W3047726430 date "2020-12-01" @default.
• W3047726430 modified "2023-10-17" @default.
• W3047726430 title "Enzyme evolution in natural products biosynthesis: target- or diversity-oriented?" @default.
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• W3047726430 doi "https://doi.org/10.1016/j.cbpa.2020.05.011" @default.
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